Mycobacterium tuberculosis 2091HD
Protein-related phenotypes
Virulence Factors
No data
PDIM (phthiocerol dimycocerosate)
Play a mainly structural role in providing a stable base for the insertion of other lipid and also play a role as a fluidity modifier, whose function could be to modulate cell wall viscosity
MmaA4
Methyltransferase forms methoxy and keto derivatives of the meromycolic acid chain
PcaA
Cyclopropane synthase that incorporates a single proximal cycloproprane ring on the <alpha>-mycolic acids and the production of cord factor in the cell wall; Required for virulence and persistance
Inhibition of cyclopropanation of cell wall mycolic acid can result in a change in lipid fluidity and cell wall permeability, and therefore a change in resistance to reactive oxygen intermediates (ROIs) and reactive nitrogen intermediates (RNIs)
Hypothetical protein
Antigen 85
Mycolyltransferase activity that transfer long-chain mycolic acids to trehalose derivatives (i.e., cord factor, a toxic glycolipid consisting of two mycolic acid molecules linked to trehalose by the hydroxyl groups of carbons 6 and 6' --> trehalose 6,6'-dimycolate (TDM), is an important immunomodulatory component of the cell wall), pivotal for the biosynthesis of the mycobacterial cell wall and for the survival of mycobacteria; Binds the cell matrix protein fibronectin thereby enhancing the uptake of mycobacteria macrophages via complement-mediated phagocytosis
Glutamate racemase
Possible conserved protein cpsA
No data
No data
Possible COA-transferase (alpha subunit)
Acetyl-CoA acetyltransferase
Carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)
Probable acyl-COA dehydrogenase fadE32
Possible linoleoyl-COA desaturase (delta(6)-desaturase)
Hypothetical protein
TRK system potassium uptake protein CeoC
Probable acyl-COA dehydrogenase fadE22
Probable acetyl-/propionyl-COA carboxylase (beta subunit) accD1
Nitrate reductase
Nitrate respiration helps the bacteria to survive in O2-depleted areas of inflammatory or necrotic tissue
Probable ferric uptake regulation protein furB
Coproporphyrinogen III oxidase
Probable hydrolase
Probable precorrin-6y methyltransferase CobL
Probable transcriptional regulatory protein (probably crp/fnr-family)
Endonuclease IV
Probable DNA repair protein RecN (recombination protein n)
Probable transcriptional regulatory protein
PhoP
Senses Mg2+ starvation, controls expression of genes involved in surface remodeling and adaptation to intracellular growth
No data
KatG
Catalase:peroxidase degrades H2O2 and organic peroxides, the major role is to catabolize the peroxides generated by phagocyte NADPH oxidase
SodC
Copper/zinc-dependent enzyme, responsible for a small part of total SOD activity in M. tuberculosis
SodA
Iron-dependent enzyme, important fro survival of intracellular pathogens during infection
No data
Mce1
Pyruvate dehydrogenase subunit E1
Cyp125
Mce2
D-alanyl-alanine synthetase A
GPL locus
Copper exporter
Carboxylesterase
Lysyl-tRNA synthetase
Prolyl-tRNA synthetase
PE family protein
Probable transposase
Protein kinase G
Probable conserved mce associated transmembrane protein
Heme uptake
MymA operon
Molybdopterin biosynthesis-like protein MoeZ
Hypothetical protein
Exochelin (smegmatis)
Lipid phosphatase
Possible transmembrane phospholipid biosynthesis bifunctionnal enzyme plsc: putative l-3-phosphoserine phosphatase (o-phosphoserine phosphohydrolase) (psp) (pspase) + 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-agp acyltransferase) (1-agpat) (lysoph
Mce3
ESX-2 (T7SS)
Possible cyclase
Probable polyketide synthase pks5
F0F1 ATP synthase subunit A
Sulfolipid-1 biosynthesis and transport
Trehalose-recycling ABC transporter
ESX-4
Fused nitrate reductase
Mce4
Fibronectin-binding protein
Mutation
Orthologous Groups
| Proteins | Pfam Domains | Tigrfam Domains | Count |
|---|---|---|---|
| Starch synthase 1, chloroplastic/amyloplastic (Q9FNF2) | Bac_DnaA_C | phosphocarrier, HPr family TIGRFAMs entry | 11 |
| Starch synthase 1, chloroplastic/amyloplastic (Q9FNF2) | Bac_DnaA_C | phosphocarrier, HPr family TIGRFAMs entry | 11 |