MPA

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ex: GCA_001044235.1 Mycobacterium paragordonae JCM 18565 L-Alanine
Mycobacterium tuberculosis XTB13-238

Protein-related phenotypes

Virulence Factors
Possible conserved protein cpsA
Rv3484
Hypothetical protein
Rv3371; Rv1514c
PcaA
pcaA
Cyclopropane synthase that incorporates a single proximal cycloproprane ring on the <alpha>-mycolic acids and the production of cord factor in the cell wall; Required for virulence and persistance
Inhibition of cyclopropanation of cell wall mycolic acid can result in a change in lipid fluidity and cell wall permeability, and therefore a change in resistance to reactive oxygen intermediates (ROIs) and reactive nitrogen intermediates (RNIs)
MmaA4
mmaA4
Methyltransferase forms methoxy and keto derivatives of the meromycolic acid chain
PDIM (phthiocerol dimycocerosate)
fadD29; mmpL7; fadD28; mas; drrB; drrA; ppsD; ppsB; fadD26; Rv2959c; Rv2958c; Rv2956
Play a mainly structural role in providing a stable base for the insertion of other lipid and also play a role as a fluidity modifier, whose function could be to modulate cell wall viscosity
Antigen 85
fbpA
Mycolyltransferase activity that transfer long-chain mycolic acids to trehalose derivatives (i.e., cord factor, a toxic glycolipid consisting of two mycolic acid molecules linked to trehalose by the hydroxyl groups of carbons 6 and 6' --> trehalose 6,6'-dimycolate (TDM), is an important immunomodulatory component of the cell wall), pivotal for the biosynthesis of the mycobacterial cell wall and for the survival of mycobacteria; Binds the cell matrix protein fibronectin thereby enhancing the uptake of mycobacteria macrophages via complement-mediated phagocytosis
Glutamate racemase
murI
Mycobactin
mbtF; mbtB
Cell-association mycobactin participates in iron internalization and/or to serve as a temporary iron-holding molecule to prevent sudden influx of excess iron if the metal suddenly becomes available after a period of iron limitation
DevRS
devS
Controls the global response to oxidative stress and low oxygen repsonse, key regulator in the oxygen starvation-induced mycobacterial dormancy response
MprAB (mycobacterial persistence regulator)
mprA; mprB
Required for establishment and maintenance of persistent infection
SodC
sodC
Copper/zinc-dependent enzyme, responsible for a small part of total SOD activity in M. tuberculosis
KatG
katG
Catalase:peroxidase degrades H2O2 and organic peroxides, the major role is to catabolize the peroxides generated by phagocyte NADPH oxidase
SodA
sodA
Iron-dependent enzyme, important fro survival of intracellular pathogens during infection
Mutation
Submission Date Amino acid mutations Description Related gene Count
2013-02-01 G72A Retains diadenylate cyclase activity glnA1, narJ, devS 100
Orthologous Groups