Mycobacterium tuberculosis KT-0106
Protein-related phenotypes
Virulence Factors
No data
PcaA
Cyclopropane synthase that incorporates a single proximal cycloproprane ring on the <alpha>-mycolic acids and the production of cord factor in the cell wall; Required for virulence and persistance
Inhibition of cyclopropanation of cell wall mycolic acid can result in a change in lipid fluidity and cell wall permeability, and therefore a change in resistance to reactive oxygen intermediates (ROIs) and reactive nitrogen intermediates (RNIs)
MmaA4
Methyltransferase forms methoxy and keto derivatives of the meromycolic acid chain
Glutamate racemase
Hypothetical protein
PDIM (phthiocerol dimycocerosate)
Play a mainly structural role in providing a stable base for the insertion of other lipid and also play a role as a fluidity modifier, whose function could be to modulate cell wall viscosity
Possible conserved protein cpsA
Antigen 85
Mycolyltransferase activity that transfer long-chain mycolic acids to trehalose derivatives (i.e., cord factor, a toxic glycolipid consisting of two mycolic acid molecules linked to trehalose by the hydroxyl groups of carbons 6 and 6' --> trehalose 6,6'-dimycolate (TDM), is an important immunomodulatory component of the cell wall), pivotal for the biosynthesis of the mycobacterial cell wall and for the survival of mycobacteria; Binds the cell matrix protein fibronectin thereby enhancing the uptake of mycobacteria macrophages via complement-mediated phagocytosis
No data
No data
Hypothetical protein
Probable hydrolase
Nitrate reductase
Nitrate respiration helps the bacteria to survive in O2-depleted areas of inflammatory or necrotic tissue
Probable ferric uptake regulation protein furB
Coproporphyrinogen III oxidase
Probable precorrin-6y methyltransferase CobL
Probable acetyl-/propionyl-COA carboxylase (beta subunit) accD1
Probable acyl-COA dehydrogenase fadE22
Possible linoleoyl-COA desaturase (delta(6)-desaturase)
Carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)
Possible COA-transferase (alpha subunit)
Acetyl-CoA acetyltransferase
PhoP
Senses Mg2+ starvation, controls expression of genes involved in surface remodeling and adaptation to intracellular growth
Endonuclease IV
Probable DNA repair protein RecN (recombination protein n)
Probable transcriptional regulatory protein
Probable transcriptional regulatory protein (probably crp/fnr-family)
No data
SodC
Copper/zinc-dependent enzyme, responsible for a small part of total SOD activity in M. tuberculosis
KatG
Catalase:peroxidase degrades H2O2 and organic peroxides, the major role is to catabolize the peroxides generated by phagocyte NADPH oxidase
SodA
Iron-dependent enzyme, important fro survival of intracellular pathogens during infection
No data
GPL locus
ESX-3 (T7SS)
Protein kinase G
Mce2
Copper exporter
Hypothetical protein
F0F1 ATP synthase subunit A
Mce1
Probable conserved mce associated transmembrane protein
Heme uptake
Fused nitrate reductase
Exochelin (smegmatis)
Probable polyketide synthase pks5
Carboxylesterase
Pyruvate dehydrogenase subunit E1
Mce3
Possible transmembrane phospholipid biosynthesis bifunctionnal enzyme plsc: putative l-3-phosphoserine phosphatase (o-phosphoserine phosphohydrolase) (psp) (pspase) + 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-agp acyltransferase) (1-agpat) (lysoph
Prolyl-tRNA synthetase
Probable transposase
MymA operon
Lipid phosphatase
Mce4
Trehalose-recycling ABC transporter
Molybdopterin biosynthesis-like protein MoeZ
Possible cyclase
Sulfolipid-1 biosynthesis and transport
ESX-2 (T7SS)
Mutation
Orthologous Groups
| Proteins | Pfam Domains | Tigrfam Domains | Count |
|---|---|---|---|
| Starch synthase 1, chloroplastic/amyloplastic (Q9FNF2) | Bac_DnaA_C | phosphocarrier, HPr family TIGRFAMs entry | 11 |
| Starch synthase 1, chloroplastic/amyloplastic (Q9FNF2) | Bac_DnaA_C | phosphocarrier, HPr family TIGRFAMs entry | 11 |