Disorder "Obesity"
Found 54 records
Disorder information
Disorder name:
Obesity
Disoder ID:
OMIM entry:
Definition:
Accumulation of substantial excess body fat.
Modifier statisitcs
Record:
54
Gene:
25
Variant:
38
Reference:
9
Effect type:
Expressivity(54)
Modifier effect:
HDL-C and Triglyceride SNP*Tx Interaction association(11)
,Risk factor(9)
,1-Year log(TRIG) Change(5)
,Altered life span(5)
,1-Year HDL Change(4)
,Altered waist circumference(4)
,Altered waist-to-height ratio(3)
,Altered waist-to-hip ratio(3)
,Altered LDL(2)
,Altered indices of obesity(2)
,Altered obesity(2)
,Altered cholesterol(1)
,Altered hepatic triglyceride content(1)
,Altered severity(1)
,Baseline HDL Change(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| LILRA3 | LILRA3:rs103294 | Expressivity | 1-Year HDL Change | P=0.0349 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
| LILRA3:rs103294 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0472 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more | |
| LEPR | LEPR:c.1604-622G>T | Expressivity | Altered life span | HR=0.65, 95% CI: 0.42-1.02, P=0.06 | rs1063539 in ADIPOQ, rs11585329 in LEPR, and rs2519757 in TSC1 were associated with improved obesity, and breast cancer disease-free survival(DFS)more | more |
| KAT2B | KAT2B:n.*1895C>T | Expressivity | Risk factor | Β=0.11, P=1.35×10(-4) | We also identified association of rs3804562 (β=0.11, P=1.35×10-4) in KAT2B gene with BMImore | more |
| IRX3 | IRX3:c.*3961G>A | Expressivity | Risk factor | P=0.146 | The rs8053360 CC and rs1126960 GG genotypes were associated with increased birth weight and BMI, especially in females.more | more |
| IRX3:c.1437G>T(p.Gln479His) | Expressivity | Risk factor | P=0.747 | The rs8053360 CC and rs1126960 GG genotypes were associated with increased birth weight and BMI, especially in females.more | more | |
| IGF1 | IGF1:c.355-178C>G | Expressivity | Altered life span | HR=1.61, 95% CI: 1.15-2.25, P=0.01 | rs1520220 in IGF1 and rs2677760 in PIK3CA were associated with worse obesity, and breast cancer disease-free survival(DFS).more | more |
| Haplotype | Haplotype:(UCP2-UCP3:rs3781907,rs11235972,rs1800849) | Expressivity | Altered LDL | P=0.037 | AAT haplotype is associated with decreased ΔLDLmore | more |
| Haplotype:(UCP2-UCP3:rs3781907,rs11235972,rs1800849:GAT) | Expressivity | Altered cholesterol | P=0.0006 | GAT haplotype is associated with increased cholesterolmore | more | |
| Haplotype:(UCP2-UCP3:rs3781907,rs11235972,rs1800849:GAT) | Expressivity | Altered LDL | P=0.024 | GAT haplotype is associated with increased LDLmore | more |