Disorder "Obesity"
Found 54 records
Disorder information
Disorder name:
Obesity
Disoder ID:
OMIM entry:
Definition:
Accumulation of substantial excess body fat.
Modifier statisitcs
Record:
54
Gene:
25
Variant:
38
Reference:
9
Effect type:
Expressivity(54)
Modifier effect:
HDL-C and Triglyceride SNP*Tx Interaction association(11)
,Risk factor(9)
,1-Year log(TRIG) Change(5)
,Altered life span(5)
,1-Year HDL Change(4)
,Altered waist circumference(4)
,Altered waist-to-height ratio(3)
,Altered waist-to-hip ratio(3)
,Altered LDL(2)
,Altered indices of obesity(2)
,Altered obesity(2)
,Altered cholesterol(1)
,Altered hepatic triglyceride content(1)
,Altered severity(1)
,Baseline HDL Change(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| ADRB2 | ADRB2:T164I | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more |
| ADRB1 | ADRB1:c.145A>G(p.Ser49Gly) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more |
| ADRB1:c.1165G>C(p.Gly389Arg) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more | |
| ADIPOQ | ADIPOQ:c.*2899G>C | Expressivity | Altered life span | HR=0.63, 95% CI: 0.20-2.01, P=0.44 | rs1063539 in ADIPOQ, rs11585329 in LEPR, and rs2519757 in TSC1 were associated with improved obesity, and breast cancer disease-free survival(DFS)more | more |