Disorder "Asthma"
Found 58 records
Disorder information
Disorder name:
Asthma
Disoder ID:
Synonyms:
malignant tumor of abdomen (disorder),Exercise induced asthma,bronchial hyperreactivity,chronic obstructive asthma,chronic obstructive asthma with acute exacerbation,chronic obstructive asthma with status asthmaticus,exercise-induced asthma
Definition:
A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.?
Modifier statisitcs
Record:
58
Gene:
23
Variant:
41
Reference:
11
Effect type:
Expressivity(57)
,Penetrance(1)
Modifier effect:
Risk factor(19)
,Altered response to corticosteroid(7)
,Altered response to leukotriene modifiers(4)
,Altered response to montelukast(4)
,Altered response to zileuton and montelukast therapy(4)
,Altered response to therapy(3)
,Altered morning PEF(2)
,Altered response to asthma therapy(2)
,Altered response to b2AR agonist(2)
,Altered response to zileuton therapy(2)
,Promoting asthmatic phenotype(2)
,Altered bronchodilator response(1)
,Altered incidence(1)
,Altered plasma concentrations of montelukast(1)
,Altered response for lung function(1)
,Altered response to inhaled corticosteroid(1)
,Altered response to treatment(1)
,Altered severity(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| LTC4S | LTC4S:c.-444A>C | Expressivity | Altered response to zileuton therapy | From review article | Mutations in LTC4S is Associated with LTRA and LTSI response and Causes a differential response to zileuton therapymore | more |
| LTA4H | LTA4H:c.-1400C>T | Expressivity | Altered response to leukotriene modifiers | From review article | Variants in ALOX5, LTA4H, LTC4S, ABCC1, CYSLTR2, and SLCO2B1 contribute to variability in response to leukotriene modifiersmore | more |
| GSTM1 | GSTM1 | Expressivity | Risk factor | P<0.05 | The GSTM1 gene is a modifier gene of GSTP1 for the risk of childhood asthma in the Japanese populationmore | more |
| GLCCI1 | GLCCI1:c.-1473T>C | Expressivity | Altered response to corticosteroid | From review article | Mutations in GLCCI is Associated with corticosteroid response potential transcriptional mechanismmore | more |
| GCLM | GCLM:-23G/T | Expressivity | Risk factor | OR=0.33, 95% CI: 0.15-0.70, P=0.036 | The -588TT/-23TT genotype was found to be associated with decreased risk of allergic asthma after adjustment for age, gender and smoking status using multivariate logistic regression analysis (OR=0.33 95% CI 0.15-0.70, p=0.036)more | more |
| GCLM:-23G/T | Expressivity | Risk factor | OR=2.03, 95% CI: 1.05-3.90, P=0.06 | The -588CT/-23GT genotype was associated with increased risk of non-allergic asthma (OR=2.03 95% CI 1.05-3.90, p=0.06)more | more | |
| GCLM:c.588C>T | Expressivity | Risk factor | OR=0.33, 95% CI; 0.15-0.70, P=0.036 | The -588TT/-23TT genotype was found to be associated with decreased risk of allergic asthma after adjustment for age, gender and smoking status using multivariate logistic regression analysis (OR=0.33 95% CI 0.15-0.70, p=0.036)more | more | |
| GCLM:c.588C>T | Expressivity | Risk factor | OR=2.03, 95% CI: 1.05-3.90, P=0.06 | The -588CT/-23GT genotype was associated with increased risk of non-allergic asthma (OR=2.03 95% CI 1.05-3.90, p=0.06)more | more | |
| FCER2 | FCER2:c.621+7T>C | Expressivity | Risk factor | From review article | A novel variant in FCER2 was associated with increased risk of exacerbations in asthmatic children taking ICSs despite generally protective effects of this medication class.Variants in CRHR1, TBX21, and FCER2 contribute to variability in response for lung function, airways responsiveness, and exacerbations in patients taking inhaled corticosteroids.more | more |
| FCER2:c.621+7T>C | Expressivity | Altered response to corticosteroid | From review article | Mutations in FCER2 is Associated with asthma exacerbations in the presence of corticosteroidsmore | more |