LY294002

Basic Information

CAS ID: 154447-36-6
Molecular Formula: C19H17NO3
Molecular Weight: 307.4 g/mol
Monoisotopic Mass: 307.1208 g/mol
Class: Small Molecule
Natural Product: No
Other Names: LY-294002
Analysis: Drug repositioning mechanism analysis

O O N O

Compound Structure and Identifier

InChI: InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 See All
InChI Key: CZQHHVNHHHRRDU-UHFFFAOYSA-N
Smiles: O=C1C=C(Oc2c1cccc2c3ccccc3)N4CCOCC4 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0954 Phosphoinositide 3-kinase inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 28691020 Target ID T0232
Uniprot ID Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation,HSCs activation,HSCs migration
Process III prevenet collagen deposition
Mechanism Targeting the FOG2/PI3K pathway

Reference Record 2

PubMed ID 28194671 Target ID T0232
Uniprot ID Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSC activation
Process III
Mechanism

Reference Record 3

PubMed ID 27878273 Target ID T0360
Uniprot ID RAC-alpha serine/threonine-protein kinase Name RAC-alpha serine/threonine-protein kinase
Model rat Fibrosis Disease Idiopathic pulmonary fibrosis
Process I regulate cytokines and growth factors,attenue inflammation
Process II EMT
Process III prevenet collagen deposition
Mechanism Targeting PI3K/Akt signaling

Reference Record 4

PubMed ID 25148875 Target ID T0360
Uniprot ID RAC-alpha serine/threonine-protein kinase Name RAC-alpha serine/threonine-protein kinase
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,HSCs proliferation
Process III
Mechanism Targeting PTEN/Akt pathway

Reference Record 5

PubMed ID 24788198 Target ID T0232
Uniprot ID Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Model vitro Fibrosis Disease Keloid
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 24303948 Target ID T0360
Uniprot ID RAC-alpha serine/threonine-protein kinase Name RAC-alpha serine/threonine-protein kinase
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation,cells apoptosis
Process III
Mechanism

Reference Record 7

PubMed ID 23986222 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 8

PubMed ID 23444088 Target ID T0954
Uniprot ID Phosphoinositide 3-kinase Name Phosphoinositide 3-kinase
Model mice Fibrosis Disease Muscle fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting PI3K-Akt-mTOR pathway

Reference Record 9

PubMed ID 19519177 Target ID T0954
Uniprot ID Phosphoinositide 3-kinase Name Phosphoinositide 3-kinase
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts activation
Process III
Mechanism Targeting PI3K-Akt pathway

Reference Record 10

PubMed ID 19434726 Target ID T0954
Uniprot ID Phosphoinositide 3-kinase Name Phosphoinositide 3-kinase
Model vitro,human Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,HSCs proliferation
Process III prevenet collagen deposition
Mechanism Targeting ERK 1/2 and PI3K-Akt pathways

Reference Record 11

PubMed ID 18495798 Target ID T0232
Uniprot ID Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Model vitro,rat Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III
Mechanism Targeting PKB/Akt signaling

Reference Record 12

PubMed ID 16841034 Target ID T0232
Uniprot ID Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 13

PubMed ID 16289155 Target ID T0232
Uniprot ID Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III
Mechanism

Reference Record 14

PubMed ID 15271999 Target ID T0232
Uniprot ID Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Model vitro Fibrosis Disease Fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting IL-13 signaling

Reference Record 15

PubMed ID 15047702 Target ID T0232
Uniprot ID Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Model vitro Fibrosis Disease Fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 16

PubMed ID 26054450 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 17

PubMed ID 29170419 Target ID T0954
Uniprot ID Phosphoinositide 3-kinase Name Phosphoinositide 3-kinase
Model vitro,human Fibrosis Disease Fibrosis
Process I
Process II cells proliferation
Process III
Mechanism

Related Link

PubChem: 3973
ChEMBL: CHEMBL98350