RAC-alpha serine/threonine-protein kinase

Basic Information

Uniprot ID: P31749
Secondary ID: B2RAM5, B7Z5R1, Q9BWB6
Symbol: AKT1
Other Name: PKB,Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Developmental protein,Kinase,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0014 MK-2206 inhibitor
D0049 ARQ-092 inhibitor
D0207 Triciribine inhibitor
D0441 Akt Inhibitor VIII inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28794469 Compound ID D0014
CAS 1032349-93-1 Name MK-2206
Model vitro Fibrosis Disease Cystic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 2

PubMed ID 28566435 Compound ID D0049
CAS 1313881-70-7 Name ARQ-092
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting AKT phosphorylation

Reference Record 3

PubMed ID 27878273 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model rat Fibrosis Disease Idiopathic pulmonary fibrosis
Process I regulate cytokines and growth factors,attenue inflammation
Process II EMT
Process III prevenet collagen deposition
Mechanism Targeting PI3K/Akt signaling

Reference Record 4

PubMed ID 26033700 Compound ID D0207
CAS 35943-35-2 Name Triciribine
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 25148875 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,HSCs proliferation
Process III
Mechanism Targeting PTEN/Akt pathway

Reference Record 6

PubMed ID 24303948 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation,cells apoptosis
Process III
Mechanism

Reference Record 7

PubMed ID 24106278 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Fibrosis
Process I
Process II myofibroblasts differentiation
Process III
Mechanism

Reference Record 8

PubMed ID 18323784 Compound ID D0432
CAS 701976-54-7 Name Akt Inhibitor II
Model vitro Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 18323784 Compound ID D0441
CAS 612847-09-3 Name Akt Inhibitor VIII
Model vitro Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism