Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Basic Information

Uniprot ID: P48736
Secondary ID: A4D0Q6, Q8IV23, Q9BZC8
Symbol: PIK3CG
Other Name: PI3-kinase subunit gamma,PI3K-gamma,PI3Kgamma,PtdIns-3-kinase subunit gamma,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma,PtdIns-3-kinase subunit p110-gamma,p110gamma,Phosphoinositide-3-kinase catalytic gamma polypeptide,Serinethreonine protein kinase PIK3CG,p120-PI3K
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Kinase,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Extracellular Extracellular enzyme Transferase

Related Compound

Target ID Name Interaction
D0394 AS605240 inhibitor
D0465 Wortmannin inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28691020 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation,HSCs activation,HSCs migration
Process III prevenet collagen deposition
Mechanism Targeting the FOG2/PI3K pathway

Reference Record 2

PubMed ID 28194671 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSC activation
Process III
Mechanism

Reference Record 3

PubMed ID 27422446 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 24788198 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model vitro Fibrosis Disease Keloid
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 20510675 Compound ID D0394
CAS 648450-29-7 Name AS605240
Model rat Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 19538942 Compound ID D0394
CAS 648450-29-7 Name AS605240
Model mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 19028980 Compound ID
CAS Name
Model mice Fibrosis Disease Peribronchial fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 18495798 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model vitro,rat Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III
Mechanism Targeting PKB/Akt signaling

Reference Record 9

PubMed ID 16841034 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 16841034 Compound ID D0465
CAS 19545-26-7 Name Wortmannin
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 16289155 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III
Mechanism

Reference Record 12

PubMed ID 15271999 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model vitro Fibrosis Disease Fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting IL-13 signaling

Reference Record 13

PubMed ID 15047702 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model vitro Fibrosis Disease Fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 14

PubMed ID 12963636 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism