Angiotensin-converting enzyme

Basic Information

Uniprot ID: P12821
Secondary ID: B0LPF0
Symbol: ACE
Other Name: DCP,ACE,Dipeptidyl carboxypeptidase I,Kininase II,,Angiotensin-converting enzyme, soluble form
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Carboxypeptidase,Hydrolase,Metalloprotease,Protease

Target Classification

Category I Category II Category III
Extracellular TIMP/MMP MMP

Related Compound

Target ID Name Interaction
D0063 Ramipril inhibitor
D0209 Lisinopril inhibitor
D0301 Enalapril inhibitor
D0438 Cilazapril inhibitor
D0460 Perindopril inhibitor
D0478 Temocapril inhibitor
D0498 Captopril inhibitor
D0504 Benazepril hydrochloride inhibitor
D0505 Benazepril inhibitor
D0508 Fosinopril inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28438648 Compound ID D0063
CAS 87333-19-5 Name Ramipril
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 25945342 Compound ID D0209
CAS 76547-98-3 Name Lisinopril
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 23673415 Compound ID D0301
CAS 75847-73-3 Name Enalapril
Model mice Fibrosis Disease Muscle fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ERK/Smad signaling

Reference Record 4

PubMed ID 22318205 Compound ID D0301
CAS 75847-73-3 Name Enalapril
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 22318205 Compound ID D0301
CAS 75847-73-3 Name Enalapril
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 6

PubMed ID 20719975 Compound ID D0209
CAS 76547-98-3 Name Lisinopril
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 20400910 Compound ID
CAS Name
Model rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 8

PubMed ID 18423812 Compound ID D0438
CAS 88768-40-5 Name Cilazapril
Model human Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 17094052 Compound ID D0063
CAS 87333-19-5 Name Ramipril
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 16971004 Compound ID D0460
CAS 82834-16-0 Name Perindopril
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting NF-κB

Reference Record 11

PubMed ID 15276022 Compound ID D0478
CAS 111902-57-9 Name Temocapril
Model mice Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 12

PubMed ID 18806606 Compound ID D0301
CAS 75847-73-3 Name Enalapril
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 13

PubMed ID 17164399 Compound ID D0301
CAS 75847-73-3 Name Enalapril
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III
Mechanism

Reference Record 14

PubMed ID 15339989 Compound ID D0504
CAS 86541-74-4 Name Benazepril hydrochloride
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 15

PubMed ID 15339989 Compound ID D0505
CAS 86541-75-5 Name Benazepril
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 16

PubMed ID 15149348 Compound ID D0505
CAS 86541-75-5 Name Benazepril
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 17

PubMed ID 11867951 Compound ID D0505
CAS 86541-75-5 Name Benazepril
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 18

PubMed ID 12411096 Compound ID D0508
CAS 98048-97-6 Name Fosinopril
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 19

PubMed ID 11592866 Compound ID D0498
CAS 62571-86-2 Name Captopril
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 20

PubMed ID 10760085 Compound ID D0301
CAS 75847-73-3 Name Enalapril
Model rat Fibrosis Disease Fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism