Oxysterols receptor LXR-beta

Basic Information

Uniprot ID:	P55055
Secondary ID:	A8K490
Symbol:	NR1H2
Other Name:	LXRB,Liver X receptor beta,Nuclear receptor NER,Nuclear receptor subfamily 1 group H member 2,Ubiquitously-expressed nuclear receptor
Class:	Single Protein
Type:	pro/anti-fibrotic
Molecular Function:	Activator,DNA-binding,Receptor

Target Classification

Category I	Category II	Category III
Intracellular	Nuclear receptor	NR1 family

Related Compound

Target ID	Name	Interaction
D0111	22(S)-Hydroxycholesterol	antagonist
D0266	T0901317	agonist
D0556	GW3965	agonist

Fibrosis Related Property

Reference Record 1

PubMed ID	27746237	Compound ID	D0111
CAS	22348-64-7	Name	22(S)-Hydroxycholesterol
Model	vitro,human,mice	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I
Process II	fibroblasts proliferation,fibroblasts migration
Process III
Mechanism	Targeting LXR pathway

Reference Record 2

PubMed ID	26667495	Compound ID	D0556
CAS	405911-17-3	Name	GW3965
Model	mice	Fibrosis Disease	Arteriolar fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID	25684370	Compound ID	D0224
CAS	898800-26-5	Name	AZ876
Model	mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID	24618263	Compound ID	D0266
CAS	293754-55-9	Name	T0901317
Model	vitro,mice	Fibrosis Disease	Skin fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting IL-6