| BioID | bio1661 |
|---|
| Name | AVAPRITINIB |
|---|
| ChEMBL ID | CHEMBL4204794 |
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| Molecular Formula | C26H27FN10 |
|---|
| Molecular Weight | 498.57 |
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| Molecular Weight (Monoisotopic) | 498.2404 |
|---|
| Type | Small molecule |
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| Max Phase | Phase 4 |
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| Target ID | Tar11 |
|---|
| Target Name | Proto-oncogene c-RAF (c-RAF) |
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| Synonyms | 70C366|AVAPRITINIB|AYVAKIT|Ayvakyt|BLU-285|C-366|X-720776|X720776 |
|---|
| Smiles | Cn1cc(-c2cc3c(N4CCN(c5ncc([C@@](C)(N)c6ccc(F)cc6)cn5)CC4)ncnn3c2)cn1 |
|---|
| Inchi | InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m0/s1 |
|---|
| Inchi Key | DWYRIWUZIJHQKQ-SANMLTNESA-N |
|---|
| Molecular Species | BASE |
|---|
| Targets | 7.0 |
|---|
| Bioactivities | 23.0 |
|---|
| Np Likeness Score | -1.68 |
|---|
| Records Key | ['AVAPRITINIB', '5; BLU-285', 'AVAPRITINIB', 'AVAPRITINIB', 'AVAPRITINIB', 'COVC-2298243685', 'Avarpritinib', 'AVAPRITINIB'] |
|---|
| Records Name | ['AVAPRITINIB', 'Avapritinib', 'AVAPRITINIB', 'AVAPRITINIB', 'AVAPRITINIB', 'AVAPRITINIB', 'Avarpritinib', 'AVAPRITINIB'] |
|---|
| Withdrawn Flag | False |
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| Orphan | 1 |
|---|
