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Effectiveness of combination the photobiomodulation therapy and triamcinolone acetonide on managing oral major aphthous ulcer in Crohn's disease: A case report
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 40696693
RATIONALE: Inflammatory bowel diseases like Crohn's disease can manifest with oral ulcers that negatively impact quality of life. Managing these stubborn symptomatic lesions requires an integrated medical and dental approach. PATIENT CONCERNS: A 23-year-old male was diagnosed with Crohn's disease 3 years ago. He was referred to the oral medicine …
Concurrent multi-systemic eosinophilic epitheliotropic disease and choledocholithiasis in a 15-year-old mixed-breed mare
Publication Year: 2025 Source: Vet Res Forum PMID: 40693031
A mixed-breed 15-year-old mare was euthanized for recurrent colic, severe weight loss, pastern ulcerative dermatitis, and coronitis without response to non-surgical medical procedures. The liver was congested with firm consistency at necropsy, and there were multi-focal white spots on Glisson's capsule. Hemorrhage, ulcer, severe folding, and hypertrophy were seen in …
Commentary: Anti-TNFα in inflammatory bowel disease: from originators to biosimilars
Publication Year: 2025 Source: Front Pharmacol PMID: 40693265
No Abstract
OGG1 augments the transcriptional activation of Foxp3 to promote iTreg differentiation for IBD alleviation
Publication Year: 2025 Source: Proc Natl Acad Sci U S A PMID: 40694333
8-oxo-7,8-dihydroguanine (8-oxoG), the most frequent form of oxidative-DNA-base lesion caused by ROS, is recognized and repaired by 8-oxoguanine DNA glycosylase 1 (OGG1) through base excision repair (BER) pathway. Beyond its role in DNA repair, OGG1 has been shown to promote transcriptional activation of proinflammatory mediators and contribute to both acute …
Paederia scandens-derived exosome-like nanoparticles as a delivery system for andrographolide to treat ulcerative colitis
Publication Year: 2025 Source: Cell Signal PMID: 40695370
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by relapsing colon inflammation. Side effects and drug resistance limit current therapies. Andrographolide (AG), an NF-kappaB pathway inhibitor, shows promise in UC treatment but suffers from poor oral bioavailability. In this study, Paederia scandens-derived exosome-like nanoparticles (P-ELNs) were used as …
Gut microbiota-host post-translational modification axis in immunometabolic diseases
Publication Year: 2025 Source: Trends Immunol PMID: 40695628
Communication between the gut microbiota and host post-translational modifications (PTMs) has been extensively characterized, and recent evidence delineates a functionally integrated gut microbiota-host PTM axis. This axis is not only essential for maintaining metabolism homeostasis but also plays diverse roles in regulating disease pathogenesis. In this review we discuss the …
Clinical Application of Chinese Herbal Medicine in Small Animal Practice
Publication Year: 2025 Source: Vet Clin North Am Small Anim Pract PMID: 40695659
Rooted in over 4000 years of empirical knowledge and systematic documentation, Chinese herbal medicine (CHM) has evolved into a sophisticated therapeutic modality for managing various medical conditions. This article explores the clinical application of CHM in small animal practice, emphasizing its unique diagnostic framework of pattern diagnosis. Key examples of …
Commentary on "Mechanistic insights into PFOS-induced inflammatory bowel disease: a network toxicology and molecular docking study"
Publication Year: 2025 Source: Int J Surg PMID: 40697017
No Abstract
A sex dependent association between the history of autoimmune disease and the development of pancreatic cancer: a case-control study of 32,640 patients
Publication Year: 2025 Source: Front Oncol PMID: 40697369
BACKGROUND: Pancreatic cancer is a highly lethal cancer with increasing incidence and poor prognosis due to late diagnosis. While several risk factors are known, evidence on a potential role of autoimmune diseases remains limited. Given the increasing prevalence of autoimmune diseases and their association with various malignancies, this study aims …
Changes in white matter microstructure in the brain of patients with inflammatory bowel disease are associated with abdominal pain
Publication Year: 2025 Source: Front Neurosci PMID: 40697271
INTRODUCTION: In recent years, interest in the brain-gut axis has increased, and interactions between the brain and the gut may be closely related to recurrent clinical symptoms in patients with inflammatory bowel disease. We aimed to investigate the changes in white matter microstructure in the brain of patients and their …
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