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S01
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Anti-inflammatory
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inflammatory
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cyclo-oxygenase; proinflammatory cytokine; oxygen…
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5-Aminosalicylates (5-ASAs); corticosteroids
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Crohn's disease and ulcerative colitis are the tw…
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12950415; 27372735; 22914295
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Details
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S02
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Immunosuppression
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Classic immunosuppressive drugs
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immunophilins; nuclear factor of activated T cell…
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azathioprine; 6-mercaptopurine; methotrexate; cic…
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Ciclosporin-A and tacrolimus bind to specific int…
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12697733; 27112707; 27411368;…
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Details
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S03
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Anti-TNF agents
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Tumor necrosis factor
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macrophages; T cells; dendritic cells; fibroblast…
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infliximab; adalimumab; golimumab; certolizumab p…
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TNF is produced by various immune and non-immune …
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20393175; 21723220; 22062358;…
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Details
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S04
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T-cell homing and retention
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T-cell trafficking
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TH1; type 1 T helper cell; TH2; type 2 T helper c…
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vedolizumab; anti-MAdCAM1 antibodies ; etrolizumab
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Inhibition of the interaction between α4β7 integr…
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23964932; 7686922; 9036954; 1…
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Details
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S05
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Angiogenesis
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cell proliferation; vascular permeability
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S1PR; NF-κB; STAT3 transcription factors
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ozanimod
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The bioactive lipid S1P has been shown to activat…
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25580263; 18815359; 25061328
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Details
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S06
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Anti-fibrosis
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fibrosis; tissue remodelling
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MMPs; myosin light chain kinase (MLCK); humanized…
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GS-5745; STNM01
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Tissue remodelling and destruction in patients wi…
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24803722; 25961845; 25961845;…
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Details
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S07
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Blockade of cytokine
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Cytokine signalling
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phosphodiesterase (PDE)4 inhibitors; Janus kinase…
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apremilast; roflumilast; filgotinib; tofacitinib;…
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Various T-cell subsets, their differentiation pat…
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16374252; 9098000; 17206128; …
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Details
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S08
|
Strengthening barrier function
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Modulation of barrier function
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Escherichia coli Nissle (EcN); anti-inflammatory …
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phosphatidylcholine (lecithin); imiquimod; monger…
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Escherichia coli Nissle (EcN) is a nonpathogenic …
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18997018; 27350728; 20926877;…
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Details
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S09
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Stem cells Transplantation
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mesenchymal stem cells (MSCs)
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fistulas; allogeneic stem cells; Cx601 cells
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MSC
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Crohn's disease is associated with the developmen…
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26116801; 10597336; 26206376;…
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Details
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S10
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Apheresis Therapy
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Adsorptive granulocyte/monocyte apheresis (GMA)
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granulocytes; monocytes; activated lymphocytes
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/
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Apheresis therapy is a novel treatment for IBD de…
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31811562; 24268950; 27843131;…
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Details
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