Help Center

Version 1.0.0 – Initial Release

This release delivers a complete set of core functionalities for data exploration and knowledge discovery.

• This is the first official release; additional datasets, analytical tools, and visualization modules will be introduced in future updates.
• User feedback is welcome and will guide subsequent development.

Search Function User Guide

Primarily includes homepage search and page-specific search functionality.

Homepage Search Fields and Content Coverage

1. Search Field Scope

The homepage search function is a global search system covering the following 10 main data categories:

• Research Articles
  Search fields: Title, Abstract, Source, DOI
  Content coverage: IBD-related research papers and journal articles
• Clinical Trials
  Search fields: Trial ID, Study Title, Disease Conditions, Interventions
  Content coverage: Clinical trial data from ClinicalTrials, DrugBank, WHO International Clinical Trials Registry Platform
• Therapeutic Targets
  Search fields: Target Name, Target ID, Target Type
  Content coverage: OMIM, TTD, UniProt
• Bioactive Compounds
  Search fields: Compound Name, Bio ID, ChEMBL ID, Synonyms
  Content coverage: Bioactive compounds from ChEMBL database
• Experimental Models
  Search fields: Model Name, Category, Description, Model Type
  Content coverage: Experimental models mainly from literature
• Investigational Drugs
  Search fields: Drug Name, Drug ID, Description, Synonyms
  Content coverage: Related information from DrugBank, PubChem and clinical trials
• Associated Diseases
  Search fields: Disease Name, Disease ID, Definition, Disease Classification
  Content coverage: Disease information related to IBD
• Pathogenesis
  Search fields: Pathogenesis, Pathology ID, Description, Other Terms
  Content coverage: IBD pathogenesis research data, mainly from literature
• Therapeutic Strategies
  Search fields: Therapeutic Strategy, Strategy ID, Mechanism, Synonyms
  Content coverage: IBD therapeutic strategies and methods, data mainly from literature
• Drug Targets
  Search fields: Compound Name, Gene Name, Mechanism of Action, Species
  Content coverage: Drug-target relationship data, mainly from PubChem and DrugBank

2. Search Function Features

• Intelligent Search
  • Supports fuzzy matching
  • Multi-field combined search
• Category Filtering
  • Can filter by data categories
  • Shows search result count for each category
  • Supports "All" and "Specific Category" search
• Popular Search Keywords
  Homepage provides some popular search keywords:
  • IBD
  • Crohn's Disease
  • Ulcerative Colitis
  • Clinical Trials

Web Pathogenesis Module Function Details

1. List Page Functions (Pathogenesis List)

Data Display Functions

• Table Display: Display all pathogenesis data in responsive table format
• Field Display:
  • ID: Pathogenesis unique identifier
  • Pathogenesis: Pathogenesis name
  • Other Terms: Other related terms
  • Description: Detailed description
  • References: Reference literature PMID
  • Details: Detail links

Search Functions

• Intelligent Search: Supports searching in pathogenesis, other terms, and description fields
• Search Feedback: Displays search result count and status information
• Clear Search: Provides functionality to clear search conditions

Interactive Experience

• Row Click: Click anywhere on a table row to jump to the detail page

2. Detail Page Functions (Pathogenesis Detail)

Basic Information Display

• Pathogenesis Card: Display complete pathogenesis information in card format
• Information Layering:
  • ID: Pathogenesis identifier
  • Pathogenesis: Pathogenesis name
  • Other Terms: Other related terms
  • Description: Detailed description (supports line break display)

Related Literature Association

• Automatically associate related research literature based on reference_pmids, where the associated literature is manually curated
• Literature Cards: Display related literature in card grid format
• Literature Information: Display title, publication date, source, PMID, DOI, etc.
• Detail Links: Direct jump to literature detail page (opens in new window)

Web Therapeutic Strategies Module Content Details

1. Data Structure Content

Core Data Fields

The therapeutic strategies module manages the following core data:

• strategy_id: Therapeutic strategy ID (primary key, format: S01, S02, S03...)
• therapy_strategy: Therapeutic strategy name
• synonyms: Synonyms/aliases
• related_targets: Related targets
• related_drugs: Related drugs
• mechanism: Mechanism of action (detailed description)
• reference_pmids: Reference literature PMID list

2. List Page Content (Therapeutic Strategies List)

Search Functions

• Multi-field Search: Supports searching in therapeutic strategy, synonyms, related targets, related drugs, and mechanism of action
• Search Hint: "Search in Therapeutic Strategy, Synonyms, Related Targets, Related Drugs, or Mechanism..."
• Search Feedback: Displays search result count and status
• Clear Search: One-click clear search conditions

Table Display Content

Display the following 8 fields:

• ID: Therapeutic strategy unique identifier
• Therapeutic Strategy: Therapeutic strategy name
• Synonyms: Synonyms (truncated display 50 characters)
• Related Targets: Related targets (truncated display 50 characters)
• Related Drugs: Related drugs (truncated display 50 characters)
• Mechanism: Mechanism of action (truncated display 50 characters)
• References: Reference literature PMID (truncated display 30 characters)
• Details: Detail links

3. Detail Page Content (Therapeutic Strategy Detail)

Basic Information Display

Display complete therapeutic strategy information in card format:

• ID: Therapeutic strategy identifier
• Therapeutic Strategy: Therapeutic strategy name
• Synonyms: Synonyms
• Related Targets: Related targets
• Related Drugs: Related drugs
• Mechanism: Mechanism of action (supports line break display)

Related Literature Association

• Automatic Association: Automatically associate related research literature based on reference_pmids, where the literature association here is also manually curated
• Literature Cards: Display related literature in responsive grid format
• Literature Information: Display title, publication date, source, PMID, DOI, etc.
• Abstract Preview: Display literature abstract (truncated display 180 characters)
• Detail Links: Direct jump to literature detail page (opens in new window)

Web Clinical Trials Module Content Details

1. Data Display Content

Clinical Trials List Page

Display the following 8 core fields:

• Trial ID: Clinical trial ID (ClinicID)
• Source ID: Original trial ID (TrialID)
• Phases: Trial phase (displayed as badges)
• Status: Trial status (color-coded badges)
• Study Results: Study results
• Start Date: Start date
• Last Update Posted: Last update date
• Details: Detail links

2. Advanced Filtering Functions

Multi-dimensional Filtering

• Phases (Phase Filtering): Filter by clinical trial phase
• Status (Status Filtering): Filter by trial status (Recruiting, Completed, Terminated, etc.)
• Gender (Gender Filtering): Filter by participant gender requirements
• Age (Age Filtering): Filter by participant age requirements
• Locations (Location Filtering): Filter by trial location/country

Intelligent Search

• Keyword Search: Supports searching in trial title, trial ID, and sponsor
• Real-time Feedback: Displays search result status and count

3. Detail Page Content

Basic Information

• Clinical ID: Clinical trial unique identifier
• Identifier: Original trial identifier
• Trial Title: Trial title
• Trial URL: Original trial page link

Study Information

• Study Results: Study results details
• Conditions: Trial conditions/disease
• Interventions: Interventions

Participant Information

• Sponsor: Sponsor
• City: Trial city
• Country/Region: Trial country/region

Enrollment Criteria

• Sex Requirement: Gender requirement
• Age Requirement: Age requirement

Study Design

• Study Type: Study type
• Phase: Trial phase

Time Information

• Start Date: Start date
• Primary Completion Date: Primary completion date
• Completion Date: Completion date

Web Investigational Drugs Module Content Details

1. List Page Content (Investigational Drugs List)

Data Display Fields

Display the following 9 core fields:

• Drugs ID: Drug unique identifier
• CID: PubChem compound ID
• Drugs: Drug name
• Identifier: Drug identifier
• Molecular Formula: Molecular formula
• Molecular Weight: Molecular weight
• Groups: Drug groups (displayed as badges)
• US Approved: US approval status
• Details: Detail links

Advanced Filtering Functions

• Groups Filtering: Filter by drug groups
• US Approved Filtering: Filter by US approval status
• Other Approved Filtering: Filter by other approval status
• Intelligent Search: Supports searching in 16 fields including drug name, ID, molecular formula, synonyms, etc.

2. Detail Page Content (Drug Detail)

Basic Information (Summary)

Display complete drug information in accordion panel format:

• Drug ID: Drug unique identifier
• Drug Name: Drug name
• CID: PubChem compound ID
• DrugBank ID: DrugBank database ID
• Modality: Drug type
• Groups: Drug groups
• US Approved: US approval status
• Other Approved: Other approval status
• Identifier: Drug identifier
• Molecular Formula: Molecular formula
• Molecular Weight: Molecular weight
• Isomeric SMILES: Isomeric SMILES
• Synonyms: Synonyms
• Phase 0-4: Clinical trial data for each phase (with help tooltips)
• Description: Drug description

Molecular Structure Visualization

• 2D Structure Display: Generate 2D molecular structure diagrams based on SMILES
• 3D Structure Display: Generate 3D molecular structures based on mol files, supporting 3D structure rotation, zooming, and other operations

Knowledge Graph

• Relationship Network: Visualize the relationship network between drugs and related entities
• Node Types: Drugs, targets, clinical trials, diseases, therapeutic strategies
• Interactive Functions: Click nodes to jump to corresponding data cards
• Relationship Labels: Display relationship types between entities

Associated Data

Drug Targets

• Target Information: Display gene name, species, mechanism of action, etc.
• PubMed Links: Direct links to related PubMed literature
• Detail Navigation: Links to target detail pages

Therapeutic Targets

• Target Name: Display therapeutic target name and type
• Detail Links: Jump to therapeutic target detail pages

Clinical Trial Phase Data

• Phase Description: Detailed explanation of the meaning of each phase of clinical trials
  • Phase 0: Exploratory trials to assess drug behavior in humans
  • Phase 1: Safety trials to determine safe dosage range
  • Phase 2: Efficacy trials to evaluate therapeutic effects
  • Phase 3: Large-scale trials to confirm efficacy and safety
  • Phase 4: Post-marketing surveillance for long-term safety and efficacy

Related Clinical Trials

• Trial Information: Display trial ID, title, phase, status, etc.
• Sponsor: Trial sponsor information
• Indications: Trial indications
• Interventions: Trial interventions
• Detail Links: Jump to clinical trial detail pages

Related Diseases

• Disease Information: Display disease name, definition, classification, etc.
• Related Drugs: Drugs related to the disease
• Mechanism of Action: Disease mechanism of action
• Detail Links: Jump to disease detail pages

Related Therapeutic Strategies

• Strategy Information: Display therapeutic strategy, synonyms, related drugs, etc.
• Mechanism of Action: Therapeutic strategy mechanism of action
• Detail Links: Jump to therapeutic strategy detail pages

Related Literature

• Literature Information: Display literature title, PMID, publication year, etc.
• Relationship Type: Display the relationship type between drugs and literature
• Relevance Score: Display literature relevance score (only showing scores above 5) - these associations are implemented through code and may have weak relevance issues
• Abstract Preview: Display literature abstract (truncated display)
• Pagination Function: Support literature pagination browsing
• Detail Links: Jump to literature detail pages

Web Bioactive Compounds Module Content Details

1. List Page Content (Bioactive Compounds List)

Data Display Fields

Display the following 12 core fields:

• Bio ID: Bioactive compound unique identifier
• Target ID: Target ID
• Target Name: Target name
• ChEMBL ID: ChEMBL database ID
• Name: Compound name
• Type: Compound type
• Max Phase: Maximum clinical trial phase
• Molecular Weight: Molecular weight
• Targets: Number of targets
• Bioactivities: Number of bioactivities
• Molecular Formula: Molecular formula
• Details: Detail links

Advanced Filtering Functions

• Type Filtering: Filter by compound type
• Max Phase Filtering: Filter by maximum clinical trial phase
• Molecular Species Filtering: Filter by molecular species
• Molecular Weight Range Filtering: Support filtering by minimum and maximum molecular weight range
• Target ID Search: Search by target ID
• Bio ID Search: Search by bioactive compound ID
• Name Search: Search by compound name
• Exact Search: Support exact search by name, ChEMBL ID, or synonyms

2. Detail Page Content (Bioactive Compound Detail)

Basic Information Display

Display complete compound information in table format:

• BioID: Bioactive compound unique identifier
• Name: Compound name
• ChEMBL ID: ChEMBL database ID (with external link)
• Molecular Formula: Molecular formula
• Molecular Weight: Molecular weight
• Molecular Weight (Monoisotopic): Monoisotopic molecular weight
• Type: Compound type
• Max Phase: Maximum clinical trial phase
• Target ID: Target ID
• Target Name: Target name
• Synonyms: Synonyms (support line break display)
• Smiles: SMILES structure
• Inchi: InChI identifier
• Inchi Key: InChI Key
• Molecular Species: Molecular species
• Withdrawn Flag: Withdrawn flag
• Orphan:

Molecular Structure Visualization

• 2D Structure Display: Generate 2D molecular structure diagrams based on SMILES
• 3D Structure Display: Generate 3D molecular structures based on mol files, supporting 3D structure rotation, zooming, and other operations
• Structure Switching: Support 2D/3D structure switching buttons

3. Data Structure Content

Core Data Fields

The bioactive compounds module manages the following core data:

• BioID: Bioactive compound ID (primary key, format: Bio1, Bio2, Bio3...)
• TargetID: Target ID
• TargetName: Target name
• ChEMBL_ID: ChEMBL database ID
• Name: Compound name
• Synonyms: Synonyms
• Type: Compound type
• Max_Phase: Maximum clinical trial phase
• Molecular_Weight: Molecular weight
• Targets: Number of targets
• Bioactivities: Number of bioactivities
• Molecular_Weight_Monoisotopic: Monoisotopic molecular weight
• Np_Likeness_Score: Natural product likeness score
• Molecular_Species: Molecular species
• Molecular_Formula: Molecular formula
• Smiles: SMILES structure
• Inchi_Key: InChI Key
• Inchi: InChI identifier
• Withdrawn_Flag: Withdrawn flag
• Orphan:
• Records_Key:
• Records_Name: Record name
• Target_Name: Target name

Web Drug Targets Module Content Details

1. List Page Content (Drug Targets List)

Data Display Fields

Display the following 9 core fields:

• Target ID: Drug target unique identifier (dtID)
• CID: PubChem compound ID
• Compound Name: Compound name
• Gene ID: Gene ID
• Gene Name: Gene name
• Species: Species (displayed as badges)
• PubMed IDs: Reference literature PMID (clickable to jump to PubMed)
• Action: Mechanism of action
• Details: Detail links

Search Functions

• Smart Search: Support searching in 8 fields including Target ID, CID, Compound Name, Gene ID, Gene Name, Species, PubMed IDs, Action
• Search Hint: "Search Target ID, CID, Compound Name, Gene ID, Gene Name, Species, PubMed IDs, Action..."

Interactive Experience

• Row Click: Click anywhere on the table row to jump to the detail page

2. Detail Page Content (Drug Target Detail)

Basic Information (Summary)

Display complete target information in accordion panel format:

• Target ID: Target unique identifier
• CID: PubChem compound ID
• Compound Name: Compound name
• Gene ID: Gene ID
• Gene Name: Gene name
• Species: Species
• PubMed IDs: Reference literature PMID (clickable to jump)
• Action: Mechanism of action

Associated Data Display

Display 5 types of associated data in accordion panel format:

1. Related Drugs

• Other drug targets associated through Gene_Name
• Display: Target ID, CID, Compound Name, Gene ID, Gene Name, Species, Action

2. Investigational Drugs

• Investigational drugs associated through CID
• Display: Drug ID, Drug Name, Type, DrugBank ID, Targets, Category, Latest Progress

3. Bioactive Compounds

• Bioactive compounds associated through Gene_Name
• Display: Compound ID, Source ID, Source Type, Compound Name, Molecular Weight, Molecular Formula, Molecular Species

4. Related Diseases

• Related diseases associated through mechanism field
• Display: Disease ID, Disease Name, Definition, Mechanism

5. Related Therapeutic Strategies

• Therapeutic strategies associated through Gene_Name
• Display: Strategy ID, Therapy Strategy, Synonyms, Related Drugs, Mechanism

• PubMed Central Search: Retrieve latest research literature from PubMed
• AI Intelligent Analysis: Use AI for intelligent literature analysis
• PDF Literature Analysis: Upload PDF files for intelligent analysis
• Intelligent Dialogue: Multi-turn dialogue with AI to acquire knowledge
• Qianfan Large Model: Utilize Baidu Qianfan large language model to provide AI assistant services