| BioID | bio1841 |
|---|
| Name | LXH254 |
|---|
| ChEMBL ID | CHEMBL4583691 |
|---|
| Molecular Formula | C25H25F3N4O4 |
|---|
| Molecular Weight | 502.49 |
|---|
| Molecular Weight (Monoisotopic) | 502.1828 |
|---|
| Type | Small molecule |
|---|
| Max Phase | Phase 2 |
|---|
| Target ID | Tar11 |
|---|
| Target Name | Proto-oncogene c-RAF (c-RAF) |
|---|
| Synonyms | LXH 254|LXH-254|LXH254|NAPORAFENIB|PAN-RAF INHIBITOR LXH254 |
|---|
| Smiles | Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCO)nc(N2CCOCC2)c1 |
|---|
| Inchi | InChI=1S/C25H25F3N4O4/c1-16-2-3-19(30-24(34)17-4-5-29-21(12-17)25(26,27)28)15-20(16)18-13-22(32-6-9-35-10-7-32)31-23(14-18)36-11-8-33/h2-5,12-15,33H,6-11H2,1H3,(H,30,34) |
|---|
| Inchi Key | UEPXBTCUIIGYCY-UHFFFAOYSA-N |
|---|
| Molecular Species | NEUTRAL |
|---|
| Targets | 14.0 |
|---|
| Bioactivities | 79.0 |
|---|
| Np Likeness Score | -1.57 |
|---|
| Records Key | ['15; LXH254', '14, LXH254', 'LXH254', 'LXH254', 'LXH254'] |
|---|
| Records Name | ['N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide', 'N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide', 'LXH254', 'N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide', 'N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide'] |
|---|
| Withdrawn Flag | False |
|---|
| Orphan | 0 |
|---|
