| BioID | bio1859 |
|---|
| Name | LIFIRAFENIB |
|---|
| ChEMBL ID | CHEMBL4209157 |
|---|
| Molecular Formula | C25H17F3N4O3 |
|---|
| Molecular Weight | 478.43 |
|---|
| Molecular Weight (Monoisotopic) | 478.1253 |
|---|
| Type | Small molecule |
|---|
| Max Phase | Phase 2 |
|---|
| Target ID | Tar11 |
|---|
| Target Name | Proto-oncogene c-RAF (c-RAF) |
|---|
| Synonyms | BEIGENE-283|BGB 283|BGB-283|LIFIRAFENIB |
|---|
| Smiles | O=C1CCc2c(Oc3ccc4c(c3)[C@@H]3[C@H](O4)[C@H]3c3nc4cc(C(F)(F)F)ccc4[nH]3)ccnc2N1 |
|---|
| Inchi | InChI=1S/C25H17F3N4O3/c26-25(27,28)11-1-4-15-16(9-11)31-24(30-15)21-20-14-10-12(2-5-17(14)35-22(20)21)34-18-7-8-29-23-13(18)3-6-19(33)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,31)(H,29,32,33)/t20-,21-,22-/m0/s1 |
|---|
| Inchi Key | NGFFVZQXSRKHBM-FKBYEOEOSA-N |
|---|
| Molecular Species | NEUTRAL |
|---|
| Targets | 4.0 |
|---|
| Bioactivities | 5.0 |
|---|
| Np Likeness Score | -0.35 |
|---|
| Records Key | ['8; BGB-283', 'lifirafenib', 'LIFIRAFENIB', 'LIFIRAFENIB', 'lifirafenib', 'EOS101357'] |
|---|
| Records Name | ['5-[(1R,1aR,6aS)-1-(6-Trifluoromethyl-1H-benzoimidazol-2-yl)-1a,6a-dihydro-1H-6-oxa-cyclopropa[a]inden-3-yloxy]-3,4-dihydro-1H-[1,8]naphthyridin-2-one', 'lifirafenib', 'LIFIRAFENIB', 'LIFIRAFENIB', 'lifirafenib', 'lifirafenib'] |
|---|
| Withdrawn Flag | False |
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| Orphan | 0 |
|---|
