| BioID | bio1901 |
|---|
| Name | DABRAFENIB |
|---|
| ChEMBL ID | CHEMBL2028663 |
|---|
| Molecular Formula | C23H20F3N5O2S2 |
|---|
| Molecular Weight | 519.57 |
|---|
| Molecular Weight (Monoisotopic) | 519.1011 |
|---|
| Type | Small molecule |
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| Max Phase | Phase 4 |
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| Target ID | Tar11 |
|---|
| Target Name | Proto-oncogene c-RAF (c-RAF) |
|---|
| Synonyms | DABRAFENIB|GSK-2118436|GSK-2118436A|GSK2118436|GSK2118436A|TAFINLAR |
|---|
| Smiles | CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 |
|---|
| Inchi | InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29) |
|---|
| Inchi Key | BFSMGDJOXZAERB-UHFFFAOYSA-N |
|---|
| Molecular Species | NEUTRAL |
|---|
| Targets | 334.0 |
|---|
| Bioactivities | 420.0 |
|---|
| Np Likeness Score | -1.24 |
|---|
| Records Key | ['12, GSK2118436, Dabrafenib', '2', '3', '7, GSK2118436', 'SID174006404', 'Tafinlar', 'Dabrafenib (GSK2118436)', '13', 'DABRAFENIB', 'DABRAFENIB', 'DABRAFENIB (GSK2118436)', 'Dabrafenib', '6', '58', 'COVC-2281802322', 'Dabrafenib', 'DABRAFENIB', 'DABRAFENIB', '1', 'D12', 'DABRAFENIB', 'DABRAFENIB', 'Dabrafenib', 'Dabrafenib (GSK2118436)', '1', 'II', 'GSK2118436', 'Dabrafenib', 'Dabrafenib (GSK2118436)', 'DB', '10', 'Dabrafenib', 'EOS100662', 'Dabrafenib'] |
|---|
| Records Name | ['N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide', 'dabrafenib', 'Dabrafenib', 'Dabrafenib', 'SID174006404', 'Dabrafenib', 'Dabrafenib (GSK2118436)', 'Dabrafenib', 'DABRAFENIB', 'DABRAFENIB', 'DABRAFENIB (GSK2118436)', 'Dabrafenib', 'Dabrafenib; Tafinlar', 'Dabrafenib', 'DABRAFENIB', 'Dabrafenib', 'DABRAFENIB', 'DABRAFENIB', 'Dabrafenib', 'N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide', 'DABRAFENIB', 'DABRAFENIB', 'Dabrafenib', 'Dabrafenib (GSK2118436)', 'Dabrafenib', 'Dabrafenib', 'Dabrafenib', 'Dabrafenib', 'Dabrafenib (GSK2118436)', 'Dabrafenib', 'Dabrafenib', 'Dabrafenib', 'DABRAFENIB', 'Dabrafenib'] |
|---|
| Withdrawn Flag | False |
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| Orphan | 0 |
|---|
