IBD Research Resource Center

BioID	bio3566
Name	NAZARTINIB
ChEMBL ID	CHEMBL3787344
Molecular Formula	C26H31ClN6O2
Molecular Weight	495.03
Molecular Weight (Monoisotopic)	494.2197
Type	Small molecule
Max Phase	Phase 2
Target ID	Tar18
Target Name	Serine/threonine-protein kinase cot (COT)
Synonyms	EGF-816\|EGF816\|NAZARTINIB\|NVP-EGF816-NX
Smiles	Cc1cc(C(=O)Nc2nc3cccc(Cl)c3n2[C@@H]2CCCCN(C(=O)/C=C/CN(C)C)C2)ccn1
Inchi	InChI=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33(26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5,8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s1
Inchi Key	IOMMMLWIABWRKL-WUTDNEBXSA-N
Molecular Species	BASE
Targets	13.0
Bioactivities	61.0
Np Likeness Score	-1.15
Records Key	['EGF816', 'COVC-2833595419', '47; EGF816', 'NAZARTINIB', 'Nazartinib', 'NAZARTINIB', 'Nazartinib', 'Nazartinib', 'NAZARTINIB', 'Nazartinib', 'Nazartinib', 'Nazartinib', 'EOS100887']
Records Name	['(R)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide', 'EGF816', '(R,E)-N-(7-Chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide', 'NAZARTINIB', 'Nazartinib', 'NAZARTINIB', 'Nazartinib', 'Nazartinib', 'NAZARTINIB', 'Nazartinib', 'Nazartinib', 'Nazartinib', 'Nazartinib']
Withdrawn Flag	False
Orphan	0