| Interventions |
This is a multi-centre longitudinal observational cohort study following paediatric inflammatory bowel disease patients, aged 6-17 years, with clinical assessment and biological sampling at three-time points over one year (0, 3 and 12 months). They will undergo a clinical assessment at each time point, including height, weight and a symptom questionnaire carried out by the study team or local clinical research facility team. Biological sampling will also occur at each visit, including blood and optional saliva and stool samples. If the patient is admitted to the hospital unexpectedly for a flare of their disease or surgery then a further disease assessment with biological sampling will take place. The study ends for the participant after their 12-month visit. Detailed clinical and phenotypic data Biological sampling including blood (cfDNA, RNA, plasma, standard disease biomarkers - CRP/ESR/FBC); saliva for microbiome analysis; stool for microbiome analysis; and gut biopsies for transcriptomics and microbiome analysis Primary outcomes include: Assessing the utility of mitochondrial DAMPs as prognostic and mechanistic biomarkers in inflammatory bowel disease Secondary outcomes include: Assessing oral-gut microbiome signatures |