| Interventions |
This is a double-blind randomized clinical trial. The randomization process of the participants took place through the unifcommand of the software (v. 4.1.3, The R Project Team, Vienna, Austria). A sequence of 60 random numbers between 0 and 2 was requested to generate the list with a random sequence. This list was under the guard of a researcher without contact with the participants who will be sequentially included, to guarantee the secrecy of the allocation. By simple rounding of the generated random numbers, participants assigned the number were placed in the control group, those assigned the number in the experimental curcumin group, and those assigned the number in the experimental curcumin group. + piperine. Thus, the following were initially included in the study: 19 participants in the Placebo group (who received starch+yellow dye capsules), 20 participants in the curcumin group (who received curcumin extract - in gastro-resistant capsule - 1g/day) and 19 patients were allocated in the curcumin+piperine group (who received curcumin and piperine extract at a dosage of 1g/day of curcumin + 10mg of piperine); All participants were instructed to take two capsules (500 mg, daily after lunch, for three months |