| Interventions |
600 IBD patients will be recruited stratified according to the immunosuppressive medication they are on. Patients must have been for at least 3 months on the following treatments: thiopurines (n=100), infliximab (anti-TNF) (n=100), combination infliximab/thiopurines (n=100), vedolizumab (n=100), ustekinumab (n=100) and tofacitinib (n=100). 200 healthy people without IBD will also be recruited. Following pre-screening, participants will be consented and enrolled in the study. Details including IBD phenotype, patient demographics and disease activity will be collected via the patient questionnaires, which will be completed after study consent is given. 40mL blood draw will be sampled at 2 time points, after 2nd dose of vaccination (days 60- 85), and 35-42 days post third dose of vaccine, to assess serology and T-cell responses. |