| Interventions |
Baseline measurement (Spring 2021): For adult patients, when they are hospitalized in The Third Xiangya Hospital, they will be asked if they are willing to take part in the program and sign the letter of contentment. Those who agree to be participants will give researchers their biological samples including blood, fecal, urine, and saliva. Those participants will also fill a questionnaire related to diet, life habits, and other environmental factors. For pediatric patients, when they are hospitalized in the Hunan Children's Hospital, their guardians will be asked if they are willing to be participants. Samples are the same with adult patients. Questionnaires will be filled by both the children and their guardians. For healthy controls, they are recruited to go to the hospital healthy center to fill the questionnaire and provide their biological samples. Those samples will be analyzed for whole gene sequencing, metagenome, metabolomics, metaproteomics, other environmental risks like algal toxins, and the number of heavy metals. First follow up (Summer 2021): Six months after the baseline measurements, blood samples are collected for laboratory tests including haemoglobin, platelets, albumin, calprotectin and CRP, and participants undergo an endoscopic examination with biopsies and scoring (Ulcerative Colitis Endoscopic Index of Severity (UCEIS) for UC, Crohn's Disease Endoscopic Index of Severity (CDEIS) for CD). Each patient should be scored for disease activity (Modified Mayo score for UC, Crohn's Disease Activity Index (CDAI) for CD). Patients who accept anti-TNFa therapy are evaluated for curative effect and antiantibody testing. The same version of the questionnaire |