| Interventions |
People were allocated randomly at the hospital to the control or intervention group by lottery until occupying the places of the group. The study consists of two periods: a wash-out period (2 weeks in which the participants will not eat foods rich in polyphenols) and an intervention period (4 weeks in which the volunteers of the intervention group will drink 250 ml/day of red wine and the volunteers of the control group will continue with the same diet as in the wash-out period). On the first day after the washout period and the last day of the intervention period, all of the participants go to the hospital after at least 10 hours of fasting. Then, they deliver a sample of faeces taken as recent to this moment as possible (in a stool collection tube introduced in an anaerobic plastic zip bag) and a sample of 24 h urine (in a sterile bottle). Then, they spit into a 15 ml Falcon sterile tube to obtain at least 3 ml of saliva. Also, they complete a questionnaire on quality of life. A sample of blood is taken by a specialist. |