Trial Details

Not Recruiting
Basic Information
Clinical ID c2943
Identifier ACTRN12616000478415
Trial Title Intravenous (IV) lidocaine infusions for 48 hours in open colorectal surgery: a prospective, randomised, double-blinded, placebo-controlled trial.
Trial URL Visit Original Page
Study Information
Study Results

No results available
Conditions bowel cancer;inflammatory bowel disease;colorectal surgery;Ileus; bowel cancer inflammatory bowel disease colorectal surgery Ileus;Anaesthesiology - Pain management;Surgery - Other surgery
Interventions Patients undergoing elective open colorectal surgery were randomised into the lidocaine group or control group. The lidocaine group received 1.5 mg/kg i.v. bolus at induction of anaesthesia immediately followed by 1 mg/kg/hr i.v. infusion for a total of 48 hours duration. On arrival at the post-anaesthesia care unit (PACU), all patients were connected to an i.v. fentanyl patient-controlled analgesia (PCA) pump (20 mcg bolus, 5 min lockout, maximum dose 240 mcg/hr). PCA fentanyl consumption and numerical pain rating scale (NRS, 0-10) at rest were recorded by a blinded non-study nurse at 30min, 1, 2, 4, 8, 12, 24, 36, 48, 60, and 72 hours post-surgery. A blinded non-study pain physician monitored the patient daily, and adjusted the PCA dose if pain was not controlled.
Participant Information
Sponsor St Vincent's Hospital Sydney Department of Anaesthesia
City -
Country/Region Australia
Enrollment Criteria
Sex Requirement ALL
Age Requirement ADULT, ELDER, OLDER_ADULT
Study Design
Study Type Interventional
Phase PHASE4
Time Information
Start Date 2025-04-24
Primary Completion Date -
Completion Date -