IBD Research Resource Center

Target ID:	dt1319
CID:	2756
Compound Name:	Cimetidine
Gene ID:	5243
Gene Name:	ABCB1
Species:	Homo sapiens (human)
PubMed IDs:	--
Action:	Substrate\|Inducer

Knowledge Graph

Target ID	CID	Compound Name	Gene ID	Gene Name	Species	Action
dt1137	54671203	Doxycycline	5243	ABCB1	Homo sapiens (human)	Doxycycline results in decreased expression of ABCB1 protein	Details
dt129	2812	Clotrimazole	5243	ABCB1	Cyprinus carpio (common carp)	Clotrimazole results in decreased expression of ABCB1 mRNA	Details
dt130	2812	Clotrimazole	5243	ABCB1	Homo sapiens (human)	Clotrimazole inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]\|clotrimazole binds to ABCB1 protein	Details
dt131	2812	Clotrimazole	5243	ABCB1	Homo sapiens (human)	Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of vinblastine]\|clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]	Details
dt132	2812	Clotrimazole	5243	ABCB1	Homo sapiens (human)	Clotrimazole results in increased expression of ABCB1 protein	Details
dt164	3365	Fluconazole	5243	ABCB1	Homo sapiens (human)	Inhibitor	Details
dt170	3446	Gabapentin	5243	ABCB1	Homo sapiens (human)	Gabapentin results in decreased activity of ABCB1 protein	Details
dt28	864	Thioctic Acid	5243	ABCB1	Mus musculus (house mouse)	[thioctic acid co-treated with saxitoxin] affects the activity of ABCB1 protein	Details
dt299	4594	Omeprazole	5243	ABCB1	Homo sapiens (human)	--	Details
dt320	4740	Pentoxifylline	5243	ABCB1	Homo sapiens (human)	[pentoxifylline co-treated with doxorubicin] results in decreased expression of ABCB1 protein\|pentoxifylline results in decreased expression of ABCB1 protein	Details

Drug ID	Drug Name	Type	DrugBank ID	Targets	Category	Latest Progress
Drug189	Cimetidine	Chemical drug	--	--	--	Under clinical trials	Details

Compound ID	Source ID	Source Type	Compound Name	Molecular Weight	Molecular Formula	Molecular Species
bio183760	CHEMBL4067549	Small molecule	ULECACICLIB	496.66	C25H33FN8S	NEUTRAL	Details
bio183761	CHEMBL4442620	Small molecule	RONICICLIB	430.45	C18H21F3N4O3S	NEUTRAL	Details
bio183762	CHEMBL1944698	Small molecule	ZOTIRACICLIB	372.47	C23H24N4O	NEUTRAL	Details
bio183763	CHEMBL5201870	Small molecule	TAGTOCICLIB	404.47	C19H28N6O4	NEUTRAL	Details
bio183764	CHEMBL1206245	Small molecule	BRICICLIB	474.42	C19H23O10PS	ACID	Details
bio183765	CHEMBL1383	Small molecule	DDA-TRIPHOSPHATE	475.18	C10H16N5O11P3	ACID	Details
bio183766	CHEMBL1160964	Small molecule	--	476.17	C9H15N6O11P3	ACID	Details
bio183767	CHEMBL5095084	Small molecule	TANUXICICLIB	312.31	C15H13FN6O	NEUTRAL	Details
bio183768	CHEMBL131890	Small molecule	ATPGAMMAS	523.25	C10H16N5O12P3S	ACID	Details
bio183769	CHEMBL374931	Small molecule	--	521.21	C11H18N5O13P3	ACID	Details

Disease ID	Disease Name	Definition	Mechanism
No data available

Strategy ID	Therapy Strategy	Synonyms	Related Drugs	Mechanism
No data available