| Drug ID: | Drug123 |
|---|---|
| Drug Name: | Alicaforsen |
| CID: | 16197725 |
| DrugBank ID: | DB06224 |
| Modality: | Small Molecule |
| Groups: | NULL |
| US Approved: | NULL |
| Other Approved: | NULL |
| Identifier: | NCT03473626, , NCT00063414, , NCT00063830 |
| Molecular Formula: | C192H225N75O98P19S19-19 |
| Molecular Weight: | 6349.0 g/mol |
| Isomeric SMILES: | CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)COP(=S)([O-])O[C@H]3C[C@@H](O[C@@H]3COP(=S)([O-])O[C@H]4C[C@@H](O[C@@H]4COP(=S)([O-])O[C@H]5C[C@@H](O[C@@H]5COP(=S)([O-])O[C@H]6C[C@@H](O[C@@H]6COP(=S)([O-])O[C@H]7C[C@@H](O[C@@H]7COP(=S)([O-])O[C@H]8C[C@@H](O[C@@H |
| Synonyms: | Alicaforsen; Alicaforsen [INN]; Intercellular adhesion molecule-1 antisense oligodeoxynucleotide; Deoxyribonucleic acid, d((R)-P-thio)(G-C-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A); 185229-68-9; DNA, d((R)-P-thio)(G-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A); J8435V445B; alicaforsenum; ALICAFORSEN [MI]; ALICAFORSEN [WHO-DD] |
| Phase 0: | 0 |
| Phase 1: | 0 |
| Phase 2: | 0 |
| Phase 3: | 0 |
| Phase 4: | 0 |
| Description: | NULL |
Molecular Structure
No molecular structure data available
Knowledge Graph
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT00063414 | ISIS 2302-CS22, A 6-Week, Active-Controlled Clinical Study to Evaluate the Effectiveness of Alicaforsen (ISIS 2302) in Patients With Mild to Moderate Active Ulcerative Colitis | PHASE2 | COMPLETED | Ionis Pharmaceuticals, Inc. | Ulcerative Colitis | DRUG: Alicaforsen | Details |
| NCT00063830 | ISIS 2302-CS27, A 6-Week, Placebo-Controlled Clinical Study to Evaluate the Effectiveness of Alicaforsen (ISIS 2302) in Patients With Mild to Moderate Active Ulcerative Colitis. | PHASE2 | COMPLETED | Ionis Pharmaceuticals, Inc. | Ulcerative Colitis | DRUG: Alicaforsen | Details |
| NCT03473626 | Phase 1 Food Effect Study for Alicaforsen Tablets | PHASE1 | COMPLETED | Atlantic Pharmaceuticals Ltd | IBD | DRUG: Alicaforsen | Details |
| NCT02128503 | Prevalence and Clinical Course of Chronic Hep B Infection in IBD and Rheumatologic Disease | None | TERMINATED | Chinese University of Hong Kong | Inflammatory Bowel Disease|Crohn Disease|Ulcerati… | OTHER: HBV DNA level monitoring | Details |
| ISRCTN14273559 | Mitochondrial DAMPs as mechanistic biomarkers of mucosal inflammation in paediatric Crohn's disease and ulcerative colitis | Not Available | Recruiting | Accord (United Kingdom) | Paediatric inflammatory bowel disease Digestive … | This is a multi-centre longitudinal observational… | Details |
| ChiCTR2000039920 | Clinical value of DNA expression of exfoliated cells in feces in the diagnosis of inflammatory bowel disease | Not Available | Recruiting | Shenzhen Second People's Hospital | IBD | Gold Standard:Results of colonoscopy and patholog… | Details |
| ISRCTN67248113 | The PRognostic effect of Environmental factors in Crohn and Colitis | Not Available | Not Recruiting | ACCORD | Inflammatory bowel disease Digestive System | Patients will be approached at routine clinic vis… | Details |
| NCT02984059 | A Pilot Study Assessing Risk Factors for Abdominal Pain in Children With Inflammatory Bowel Disease: The ALLAY Study | Not Available | Not recruiting | Connecticut Children's Medical Center | Inflammatory Bowel Disease | Genetic: Genomic DNA;Genetic: RNA analysis;Geneti… | Details |
| NCT02503696 | Sample Collection Study to Evaluate DNA Markers in Subjects With Inflammatory Bowel Disease (IBD) | Not Available | Not recruiting | Exact Sciences Corporation | Inflammatory Bowel Disease;Colorectal Neoplasms;D… | Device: Stool Collection Kit | Details |
| NCT01860963 | Prevalence of Anal Dysplasia in Patients With Inflammatory Bowel Disease and Healthy Controls | Not Available | Not recruiting | Stanford University | Anal Squamous Intraepithelial Lesion (ASIL);HPV D… | Procedure: Anal Pap smear and HPV DNA testing | Details |
| NCT01819766 | Detection of Advanced Colorectal Neoplasia by Stool DNA in Inflammatory Bowel Disease: OCEANIA Study | Not Available | Not recruiting | Exact Sciences Corporation | Inflammatory Bowel Disease (IBD);Primary Sclerosi… | None | Details |
| NCT01793168 | Coordination of Rare Diseases at Sanford | Not Available | Recruiting | Sanford Health | Rare Disorders;Undiagnosed Disorders;Disorders of… | None | Details |
| NCT01653054 | The Incidence of Abnormal Anal Pap Smears in Patients With Inflammatory Bowel Disease | Not Available | Not recruiting | Montefiore Medical Center | IBD | Procedure: Anal Pap Smear, HPV DNA Testing | Details |
| EUCTR2010-022215-19-GB | A Pharmacokinetic Study Of The Combined Use Of Recombinant Human GH And IGF-1 In Children With Inflammatory Bowel (Crohn) Disease __ - Combination rhGH + rhIGF-1 in childhood/adolescent Crohn | PHASE2 | Not Recruiting | Greater Glasgow & Clyde NHS | Impaired growth in Paediatric Crohn's disease Me… | Trade Name: Increlex Product Name: Increlex 10mg/… | Details |
| ISRCTN30255103 | Colorectal cancer screening by quantitative analysis of DNA isolated from exfoliated cells sampled from the surface of human rectal mucosa: A pilot study | Not Available | Not Recruiting | Colonix Medical Ltd (UK) | Colorectal cancer; inflammatory bowel disease Ca… | This study was conducted with two distinct groups… | Details |
| NCT05916274 | Exploration of the Activity of DNA Located Outside of Cellular Nucleus to Amplify Inflammation in Inflammatory Bowel Disease in Children Through Biological Pathway Cyclic GMP-AMP Synthase (cGAS) - Stimulator of Interferon Genes (STING) | None | COMPLETED | Centre Hospitalier Rgional d'Orlans | Inflammatory Bowel Diseases|Crohn Disease|Ulcerat… | BIOLOGICAL: Blood and fecal samples|PROCEDURE: Co… | Details |
| NCT03467841 | Cytomegalovirus Infection in Steroid-refractory Ulcerative Colitis | None | UNKNOWN | Dr mohammedRmadan hamad | Cmv Colitis | DEVICE: CMV IgM, IgG in blood real time PCR for s… | Details |
| NCT03172195 | Detection of Herpesvirus DNA (CMV, EBV, HHV-6 and HSV) in Colonic Tissue: Impact on Ulcerative Colitis Flare-up | None | ACTIVE_NOT_RECRUITING | Centre Hospitalier Universitaire de Saint Etienne | Colitis, Ulcerative | PROCEDURE: rectosigmoidoscopy|BIOLOGICAL: biopsie… | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||
Alicaforsen, an Antisense Inhibitor of Intercellular Adhesion Molecule-1, in th…
PMID: 29207381
Year: 2018
Relationship Type:
Treatment
Score: 6.3
BACKGROUND: Data on the efficacy of intercellular adhesion molecule-1 antisense oligonucleotide alicaforsen in ulcerative colitis (UC) is inconsisten…
Alicaforsen in the treatment of pouchitis
PMID: 29067882
Year: 2017
Relationship Type:
Treatment
Score: 6.3
Alicaforsen is a 20-base antisense oligonucleotide inhibiting ICAM-1 production, which is an important adhesion molecule involved in leukocyte migrat…
Alicaforsen for the treatment of inflammatory bowel disease
PMID: 28670932
Year: 2017
Relationship Type:
Treatment
Score: 6.3
Intracellular adhesion molecule-1 (ICAM-1), is a transmembrane glycoprotein of the immunoglobulin family, constitutively expressed on vascular endoth…