Drug ID:Drug124
Drug Name:HE3286
CID:16739648
DrugBank ID:DB05212
Modality:Small Molecule
Groups:investigational
US Approved:NO
Other Approved:NO
Identifier: NCT00628433
Molecular Formula:C21H30O3
Molecular Weight:330.5 g/mol
Isomeric SMILES:C[C@]12CC[C@@H](CC1=C[C@@H]([C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]4(C#C)O)C)O)O
Synonyms:Triolex; HE3286; 1001100-69-1; HE 3286; HE-3286; Pregn-5-en-20-yne-3,7,17-triol, (3beta,7beta,17alpha)-; PH8858757I; 3beta,7beta,17beta-Trihydroxy-17alpha-ethynylandrost-5-ene; 17alpha-ethynyl-5-androstene-3beta,7beta,17beta-triol; (1R,3aS,3bR,4R,7S,9aR,9bS,11aS)-1-ethynyl-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta(a)phenanthrene-1,4,7-triol
Phase 0: 0
Phase 1: 6
Phase 2: 5
Phase 3: 0
Phase 4: 0
Description:NULL

Molecular Structure

2D Molecular Structure

Knowledge Graph

dtIDCIDCompound NameGene IDGene NameSpeciesPubMed IDsAction
dt1024 16739648 He3286 2908 NR3C1 Homo sapiens (human) None
dt1025 16739648 He3286 36 ACADSB Mus musculus (house mouse) 22384159 17-ethynyl-5-androstene-3, 7, 17-triol binds to ACADSB protein
dt1026 16739648 He3286 8310 ACOX3 Mus musculus (house mouse) 22384159 17-ethynyl-5-androstene-3, 7, 17-triol binds to ACOX3 protein
dt1027 16739648 He3286 158 ADSL Mus musculus (house mouse) 22384159 17-ethynyl-5-androstene-3, 7, 17-triol binds to ADSL protein
dt1028 16739648 He3286 178 AGL Mus musculus (house mouse) 22384159 17-ethynyl-5-androstene-3, 7, 17-triol binds to AGL protein
dt1029 16739648 He3286 593 BCKDHA Mus musculus (house mouse) 22384159 17-ethynyl-5-androstene-3, 7, 17-triol binds to BCKDHA protein
dt1030 16739648 He3286 6347 CCL2 Homo sapiens (human) 22384159 17-ethynyl-5-androstene-3, 7, 17-triol results in decreased expression of CCL2
dt1031 16739648 He3286 729230 CCR2 Homo sapiens (human) 22384159 17-ethynyl-5-androstene-3, 7, 17-triol results in decreased expression of CCR2
dt1032 16739648 He3286 10523 CHERP Mus musculus (house mouse) 22384159 17-ethynyl-5-androstene-3, 7, 17-triol binds to CHERP protein
dt1033 16739648 He3286 23019 CNOT1 Mus musculus (house mouse) 22384159 17-ethynyl-5-androstene-3, 7, 17-triol binds to CNOT1 protein

  • No data available

Phase Distribution
Phase Description
  • Phase 0: Exploratory trials to assess drug behavior in humans
  • Phase 1: Safety trials to determine safe dosage range
  • Phase 2: Efficacy trials to evaluate therapeutic effects
  • Phase 3: Large-scale trials to confirm efficacy and safety
  • Phase 4: Post-marketing surveillance for long-term safety and efficacy

Trial IDTitlePhaseStatusSponsorIndicationsInterventions
NCT00628433 Safety and Pharmacokinetics Study of HE3286 in Patients With Active, Mild-to-Moderate Ulcerative Colitis PHASE1|PHASE2 COMPLETED Harbor Therapeutics Ulcerative Colitis DRUG: Placebo|DRUG: HE3286 Details
NCT05668013 A Study to Evaluate the Long-Term Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease PHASE2 ACTIVE_NOT_RECRUITING Teva Branded Pharmaceutical Products R&D LLC Crohn Disease|Colitis, Ulcerative DRUG: TEV-48574 Dose Regimen A|DRUG: TEV-48574 Do… Details
NCT05666960 R-3750 in Patients With Mild to Moderate Ulcerative Colitis PHASE1 RECRUITING Rise Therapeutics LLC Ulcerative Colitis Chronic Mild|Ulcerative Coliti… DRUG: R-3750 Details
NCT05638347 A Trial of HRS-7085 Tablet in Healthy Participants With and Without Food Effect. PHASE1 COMPLETED Atridia Pty Ltd. Inflammatory Bowel Disease DRUG: HRS-7085 tablets|DRUG: Placebo tablet Details
NCT07168434 Saccharomyces Boulardii CNCM I-745 in Irritable Bowel Syndrome PHASE3 RECRUITING Biocodex IBS (Irritable Bowel Syndrome)|IBS-D (Diarrhea-pr… DRUG: Saccharomyces Boulardii 250 MG|DRUG: Placeb… Details
NCT05611671 A Study to Evaluate MORF-057 in Adults With Moderately to Severely Active UC PHASE2 ACTIVE_NOT_RECRUITING Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company) Inflammatory Bowel Diseases|Colitis, Ulcerative DRUG: MORF-057|DRUG: Placebo Details
NCT05549323 A Study to Learn About the Safety, Effects and Pharmacokinetics of Study Medication (PF-07054894) for the Treatment of Ulcerative Colitis PHASE1 TERMINATED Pfizer Ulcerative Colitis DRUG: PF-07054894|DRUG: Placebo Details
NCT05536440 A Study to Learn About Study Medicine Called PF-07261271 in Healthy People PHASE1 COMPLETED Pfizer Healthy DRUG: PF-07261271|DRUG: Placebo Details
NCT05509777 A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease PHASE3 RECRUITING Eli Lilly and Company Crohn's Disease DRUG: Mirikizumab Details
NCT05499130 A Study to Test the Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease PHASE2 COMPLETED Teva Branded Pharmaceutical Products R&D, Inc. Crohn Disease|Colitis, Ulcerative DRUG: TEV-48574|DRUG: Placebo Details
NCT05466890 Phase 2a to Evaluate PL-8177 in Subjects with Active Ulcerative Colitis (UC) PHASE2 ACTIVE_NOT_RECRUITING Palatin Technologies, Inc Ulcerative Colitis|Ulcerative Colitis Acute|Ulcer… DRUG: PL8177 Placebo|DRUG: PL8177 Details
NCT05452304 AZD7798 Safety, Tolerability, and Pharmacokinetics After a Single Ascending and Repeat Dose Administrations to Healthy Subjects, and Patients With Crohn's Disease PHASE1 COMPLETED AstraZeneca Healthy Subjects|Crohns Disease BIOLOGICAL: AZD7798|BIOLOGICAL: Placebo Details
NCT05389709 A Pharmacy-based Observational Study to Learn More About Iberogast Advance in the Real-world Setting NULL COMPLETED Bayer Functional Gastrointestinal Disorders Such as Irr… DRUG: Iberogast (STW5-II, BAY98-7410) Details
NCT05316220 A Study to Assess Adverse Events and Change in Disease Condition of Mesalamine Capsules in Children Aged 5 to 17 Years With Ulcerative Colitis PHASE3 WITHDRAWN AbbVie Ulcerative Colitis (UC) DRUG: Mesalamine|DRUG: Placebo Details
NCT05291689 A Phase 2a Open-Label Study to Evaluate the Efficacy and Safety of MORF-057 in Adults With UC PHASE2 COMPLETED Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company) Inflammatory Bowel Diseases|Colitis, Ulcerative DRUG: MORF-057 Details
NCT05242484 A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis PHASE2 ACTIVE_NOT_RECRUITING Janssen Research & Development, LLC Colitis, Ulcerative BIOLOGICAL: Guselkumab|BIOLOGICAL: Golimumab|BIOL… Details
NCT05242471 A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease PHASE2 ACTIVE_NOT_RECRUITING Janssen Research & Development, LLC Crohn's Disease BIOLOGICAL: Guselkumab|BIOLOGICAL: Golimumab|BIOL… Details
NCT05239702 Clinical Study of Targeting CD7 CAR-T Cells in the Treatment of Autoimmune Diseases EARLY_PHASE1 UNKNOWN Zhejiang University Crohn Disease|Ulcerative Colitis|Dermatomyositis|… BIOLOGICAL: CD7 CAR T-cells Details
NCT05180279 The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis NA COMPLETED Rush University Medical Center Ulcerative Colitis BEHAVIORAL: 7-day sleep lab Details
NCT07421011 Pharmacokinetics, Bioequivalence, and Safety Study of Trimedat® 76,95 mg Orally Disintegrating Tablets and Trimedat® 100 mg Tablets in Healthy Volunteers. PHASE1 RECRUITING Valenta Pharm JSC Irritable Bowel Syndrome|Gallstone Disease|GERD|B… DRUG: Trimedat® Details

Disease IDDisease NameDefinitionCategoryRelated DrugsMechanism
No data available

Strategy IDTherapeutic StrategySynonymsRelated DrugsMechanism
S06 Anti-fibrosis fibrosis; tissue remodelling GS-5745; STNM01 Tissue remodelling and destruction in patients with IBD is … Details
S07 Blockade of cytokine Cytokine signalling apremilast; roflumilast; filgotinib; tofacitinib; ABT494; ABT-874; ustekinumab; isankizumab; LY-2525623; AMG139; MEDI2079; guselkumab Various T-cell subsets, their differentiation pathways and … Details

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