Drug ID:Drug130
Drug Name:Telotristat Etiprate
CID:25253377
DrugBank ID:NULL
Modality:Small Molecule
Groups:NULL
US Approved:NULL
Other Approved:NULL
Identifier: NCT01456052
Molecular Formula:C36H35ClF3N7O6
Molecular Weight:754.2 g/mol
Isomeric SMILES:CCOC(=O)[C@H](CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)O[C@H](C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F)F)N.C1=CC=C(C=C1)C(=O)NCC(=O)O
Synonyms:Telotristat etiprate; 1137608-69-5; LX1606 Hippurate; LX1032 hippurate; LX-1606 Hippurate; UNII-3T25U84H4U; 3T25U84H4U; LX 1032 HIPPURATE; LX-1032 HIPPURATE; LX 1606 Hippurate
Phase 0: 0
Phase 1: 0
Phase 2: 0
Phase 3: 0
Phase 4: 0
Description:NULL

Molecular Structure

2D Molecular Structure

Knowledge Graph

dtIDCIDCompound NameGene IDGene NameSpeciesPubMed IDsAction
No data available

  • No data available

Phase Distribution
Phase Description
  • Phase 0: Exploratory trials to assess drug behavior in humans
  • Phase 1: Safety trials to determine safe dosage range
  • Phase 2: Efficacy trials to evaluate therapeutic effects
  • Phase 3: Large-scale trials to confirm efficacy and safety
  • Phase 4: Post-marketing surveillance for long-term safety and efficacy

Trial IDTitlePhaseStatusSponsorIndicationsInterventions
NCT01456052 A Study to Evaluate Safety and Efficacy of Telotristat Etiprate (LX1606) in Participants With Acute, Mild to Moderate Ulcerative Colitis PHASE2 COMPLETED Lexicon Pharmaceuticals Ulcerative Colitis DRUG: Telotristat Etiprate|DRUG: Placebo Details

Disease IDDisease NameDefinitionCategoryRelated DrugsMechanism
No data available

Strategy IDTherapeutic StrategySynonymsRelated DrugsMechanism
No data available

Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606)…

PMID: 26206858
Year: 2015
Relationship Type: Treatment Score: 6.3

Mucosal inflammation is accompanied by an alteration in 5-HT. Intestinal 5-HT synthesis is catalyzed by tryptophan hydroxylase 1 (Tph1) and we have s…

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