Drug ID:Drug142
Drug Name:Doxycycline
CID:54671203
DrugBank ID:DB00254
Modality:Small Molecule
Groups:approved|investigational
US Approved:YES
Other Approved:YES
Identifier: NCT00355602, , NCT02606032, , NCT03546868
Molecular Formula:C22H24N2O8
Molecular Weight:444.4 g/mol
Isomeric SMILES:C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
Synonyms:doxycycline; 564-25-0; Doxytetracycline; Doxycycline (anhydrous); Doxy-Caps; Doxiciclina; Doxycyclinum; Monodox; Oracea; Doxycycline anhydrous
Phase 0: 7
Phase 1: 45
Phase 2: 114
Phase 3: 67
Phase 4: 96
Description:A synthetic tetracycline derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (malaria, falciparum). [PubChem]

Molecular Structure

2D Molecular Structure

Knowledge Graph

dtIDCIDCompound NameGene IDGene NameSpeciesPubMed IDsAction
dt1131 54671203 Doxycycline 4312 MMP1 Homo sapiens (human) Inhibitor
dt1132 54671203 Doxycycline 4317 MMP8 Homo sapiens (human) Inhibitor
dt1133 54671203 Doxycycline 64979 MRPL36 Homo sapiens (human) Inhibitor
dt1134 54671203 Doxycycline 5599 MAPK8 Homo sapiens (human) None
dt1135 54671203 Doxycycline 1632 ECI1 Homo sapiens (human) Inhibitor
dt1136 54671203 Doxycycline 1432 MAPK14 Homo sapiens (human) None
dt1137 54671203 Doxycycline 5243 ABCB1 Homo sapiens (human) 11147995 Doxycycline results in decreased expression of ABCB1 protein

  • No data available

Phase Distribution
Phase Description
  • Phase 0: Exploratory trials to assess drug behavior in humans
  • Phase 1: Safety trials to determine safe dosage range
  • Phase 2: Efficacy trials to evaluate therapeutic effects
  • Phase 3: Large-scale trials to confirm efficacy and safety
  • Phase 4: Post-marketing surveillance for long-term safety and efficacy

Trial IDTitlePhaseStatusSponsorIndicationsInterventions
NCT02606032 Trial of Antimicrobials Versus Placebo in Addition to Fecal Transplant Therapy in Ulcerative Colitis PHASE2 COMPLETED Hamilton Health Sciences Corporation Ulcerative Colitis DRUG: Metronidazole|DRUG: Doxycycline|DRUG: Terbi… Details
NCT03986996 Antimicrobial Therapy for Ulcerative Colitis (UC) PHASE2 TERMINATED Wolfson Medical Center Ulcerative Colitis DRUG: amoxicillin, metronidazole and doxycycline|… Details
NCT00355602 Antibiotics for the Treatment of Ulcerative Colitis None COMPLETED University of Dundee Colitis, Ulcerative DRUG: Cefuroxime|DRUG: Ciprofloxacin|DRUG: Clarit… Details

Disease IDDisease NameDefinitionCategoryRelated DrugsMechanism
No data available

Strategy IDTherapeutic StrategySynonymsRelated DrugsMechanism
No data available

Randomized Trial of Ciprofloxacin Doxycycline and Hydroxychloroquine Versus Bud…

PMID: 32681228
Year: 2021
Relationship Type: Treatment Score: 6.5

BACKGROUND: Increased mucosa-associated E. coli are present in Crohn's disease, but their role in pathogenesis is uncertain. AIMS: To assess efficacy…

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Potential Association of Doxycycline With the Onset of Primary Sclerosing Chola…

PMID: 31567143
Year: 2022
Relationship Type: Treatment Score: 6.5

BACKGROUND: Primary sclerosing cholangitis (PSC) is linked to inflammatory bowel diseases (IBD). Evidence suggests an association between the gut mic…

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A new therapeutic association to manage relapsing experimental colitis: Doxycyc…

PMID: 25917208
Year: 2015
Relationship Type: Treatment Score: 6.3

Immunomodulatory antibiotics have been proposed for the treatment of multifactorial conditions such as inflammatory bowel disease. Probiotics are abl…

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