| Drug ID: | Drug15 |
|---|---|
| Drug Name: | Clotrimazole |
| CID: | 2812 |
| DrugBank ID: | DB00257 |
| Modality: | Small Molecule |
| Groups: | approved |
| US Approved: | YES |
| Other Approved: | YES |
| Identifier: | NCT00061282 |
| Molecular Formula: | C22H17ClN2 |
| Molecular Weight: | 344.8 g/mol |
| Isomeric SMILES: | C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 |
| Synonyms: | clotrimazole; 23593-75-1; Clotrimazol; Mycosporin; Empecid; Mykosporin; Gyne lotrimin; Chlotrimazole; Trimysten; Gyne-Lotrimin |
| Phase 0: | 0 |
| Phase 1: | 8 |
| Phase 2: | 14 |
| Phase 3: | 22 |
| Phase 4: | 12 |
| Description: | An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. [PubChem] |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt129 | 2812 | Clotrimazole | 5243 | ABCB1 | Cyprinus carpio (common carp) | 22559005 | Clotrimazole results in decreased expression of ABCB1 mRNA |
| dt130 | 2812 | Clotrimazole | 5243 | ABCB1 | Homo sapiens (human) | 8917702 | Clotrimazole inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]|clotrimazole binds to ABCB1 protein |
| dt131 | 2812 | Clotrimazole | 5243 | ABCB1 | Homo sapiens (human) | 12235267 | Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of vinblastine]|clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon] |
| dt132 | 2812 | Clotrimazole | 5243 | ABCB1 | Homo sapiens (human) | 8632764 | Clotrimazole results in increased expression of ABCB1 protein |
| dt133 | 2812 | Clotrimazole | 8647 | ABCB11 | Homo sapiens (human) | 24014644 | Clotrimazole inhibits the reaction [ABCB11 protein results in increased transport of taurocholic acid]|clotrimazole results in decreased activity of ABCB11 protein |
| dt134 | 2812 | Clotrimazole | 18671 | Abcb1a | Mus musculus (house mouse) | 12235267 | Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon] |
| dt135 | 2812 | Clotrimazole | 1244 | ABCC2 | Homo sapiens (human) | 11836020 | Clotrimazole results in increased expression of ABCC2 protein|clotrimazole results in increased expression of ABCC2 mRNA |
| dt136 | 2812 | Clotrimazole | 8714 | ABCC3 | Homo sapiens (human) | 27507784 | Clotrimazole results in increased expression of ABCC3 mrna|sb 203580 inhibits the reaction [clotrimazole results in increased expression of ABCC3 mrna]|mapk14 promotes the reaction [clotrimazole results in increased expression of ABCC3 mrna] |
| dt137 | 2812 | Clotrimazole | 53 | ACP2 | Rattus norvegicus (Norway rat) | 30047161 | Clotrimazole results in increased expression of ACP2 mRNA |
| dt138 | 2812 | Clotrimazole | 53616 | ADAM22 | Rattus norvegicus (Norway rat) | 30047161 | Clotrimazole results in decreased expression of ADAM22 mRNA |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT00061282 | Clotrimazole Enemas for Pouchitis in Children and Adults | PHASE1|PHASE2 | TERMINATED | Web | Ulcerative Colitis|Pouchitis|Ileitis|Inflammatory… | DRUG: Clotrimazole | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||
No related literature
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