Drug ID:Drug178
Drug Name:Dersalazine sodium
CID:135565341
DrugBank ID:DB06251
Modality:Small Molecule
Groups:NULL
US Approved:NULL
Other Approved:NULL
Identifier: NCT00808977
Molecular Formula:C35H31N6NaO4
Molecular Weight:622.6 g/mol
Isomeric SMILES:CC1=NC2=C(N1CC3CCN(CC3)C(=O)/C=C(/C4=CC=CC=C4)\\C5=CC=C(C=C5)N=NC6=CC(=C(C=C6)O)C(=O)[O-])C=CN=C2.[Na+]
Synonyms:Dersalazine sodium; Sodium dersalazine; UR-12746S; UNII-BAB844203H; 367249-56-7; BAB844203H; Benzoic acid, 2-hydroxy-5-(2-(4-((1Z)-3-(4-((2-methyl-1H-imidazo(4,5-c)pyridin-1-yl)methyl)-1-piperidinyl)-3-oxo-1-phenyl-1-propen-1-yl)phenyl)diazenyl)-, sodium salt (1:1); sodium;2-hydroxy-5-[[4-[(Z)-3-[4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]piperidin-1-yl]-3-oxo-1-phenylprop-1-enyl]phenyl]diazenyl]benzoate; Dersalazine (sodium); DERSALAZINE SODIUM [WHO-DD]
Phase 0: 0
Phase 1: 0
Phase 2: 0
Phase 3: 0
Phase 4: 0
Description:NULL

Molecular Structure

2D Molecular Structure

Knowledge Graph

dtIDCIDCompound NameGene IDGene NameSpeciesPubMed IDsAction
No data available

  • No data available

Phase Distribution
Phase Description
  • Phase 0: Exploratory trials to assess drug behavior in humans
  • Phase 1: Safety trials to determine safe dosage range
  • Phase 2: Efficacy trials to evaluate therapeutic effects
  • Phase 3: Large-scale trials to confirm efficacy and safety
  • Phase 4: Post-marketing surveillance for long-term safety and efficacy

Trial IDTitlePhaseStatusSponsorIndicationsInterventions
NCT00808977 A Phase II Study to Explore the Safety and Activity of Dersalazine in Patients With Mild to Moderate Ulcerative Colitis PHASE2 COMPLETED Palau Pharma S.L.U. Ulcerative Colitis DRUG: Dersalazine sodium|DRUG: Mesalazine|DRUG: P… Details
NCT00408174 Balsalazide Disodium vs. Mesalamine in Mildly to Moderately Active Ulcerative Colitis PHASE3 COMPLETED Bausch Health Americas, Inc. Inflammatory Bowel Disease|Ulcerative Colitis DRUG: Balsalazide disodium Details
NCT03581149 Tolerability and Efficacy of Sodium Picosulfate/Magnesium Citrate Versus PEG/Ascorbic Acid in Ulcerative Colitis Patients PHASE4 UNKNOWN American University of Beirut Medical Center Ulcerative Colitis DRUG: Sodium Picosulfate/Magnesium Citrate Laxati… Details
NCT00269438 New Tablet Formulation and Dosing Regimen of Balsalazide Disodium in Mildly to Moderately Active Ulcerative Colitis PHASE3 COMPLETED Bausch Health Americas, Inc. Ulcerative Colitis DRUG: 5 ASA, enemas, suppositories, corticosteroi… Details
NCT00867438 Efficacy and Tolerability of a New Oral Extended-Release Formulation Containing Parnaparin Sodium, Administered Add-on Therapy PHASE2 COMPLETED Cosmo Technologies Ltd Ulcerative Colitis PROCEDURE: Sigmoidoscopy Details
NCT03110198 Mesalazine With Hydrocortisone Sodium Succinate Enema for 4-Week Treatment in Patients With Ulcerative Colitis PHASE4 UNKNOWN Xijing Hospital of Digestive Diseases Ulcerative Colitis, Unspecified DRUG: Mesalazine|DRUG: hydrocortisone sodium succ… Details
NCT00618202 A Single Dose, 2-Period, 2-Treatment, 2-Way Crossover Bioequivalency Study of Balsalazide Disodium 750 mg Capsules Under Fasting Conditions None COMPLETED Roxane Laboratories Ulcerative Colitis DRUG: Balsalazide Details
NCT05726097 Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure PHASE3 COMPLETED Region Skane Colon Cancer; Inflammatory Bowel Diseases; Gastro… DRUG: polyethylene glycol; DRUG: sodium phosphate… Details
ChiCTR2200056969 Efficacy, tolerability and safety of Sodium picosulphate/magnesium citrate versus 3-L polyethylene glycol for bowel preparation for patients with Inflammatory Bowel Disease Not Available Recruiting Shenzhen Hospital of Southern Medical University Bowel preparation Experimental group:intake sodium picosulfate/magn… Details
JPRN-UMIN000046015 A prospective, controlled, randomized, assessor-blind, comparative study of a new oral bowel cleanser (Sodium Picosulfate/Magnesium Citrate) versus existing oral bowel cleanser (Magnesium Citrate) in pediatric colonoscopy preparation. - A prospective, controlled, randomized, assessor-blind, comparative study of a new oral bowel cleanser (Sodium Picosulfate/Magnesium Citrate) versus existing oral bowel cleanser (Magnesium Citrate) in pediatric colonoscopy preparation. Not Available Not Recruiting Saitama children's Medical Center Division of Gastroenterology and Hepatology Inflammatory bowel disease, Functional gastrointe… PICOPREP MAGCOROL Powder Details
EUCTR2018-001402-28-ES PROTOCOL FOR THE OPTIMIZATION OF THE PREPARATION FOR THE COLONOSCOPY IN PATIENTS WITH INTESTINAL INFLAMMATORY DISEASE PHASE4 Authorised Hospital Universitario La Paz preparation in patients with inflammatory bowel d… Trade Name: Moviprep Sabor Naranja … Details
NCT03593252 Mechanical Bowel Prep and Prophylactic Oral Antibiotic Use in Children: Implications for Intestinal Surgery Complications Not Available Not recruiting McMaster University Colostomy Stoma;Ileostomy - Stoma;Jejunostomy Sto… Drug: Senna;Drug: Sodium Picosulfate, Magnesium O… Details
ACTRN12618000617268 The use and efficacy of transabdominal ultrasound to assess bowel preparation prior to colonoscopy to avoid unnecessary repeat colonoscopies. Not Available Not Recruiting Concord Hospital Gastroenterology Department Crohn's disease;Ulcerative Colitis;Colonoscopy pr… Whether transabdominal ultrasound can accurately … Details
NCT05456763 Butyrate in Pediatric Inflammatory Bowel Disease None COMPLETED Centre of Postgraduate Medical Education Inflammatory Bowel Diseases DIETARY_SUPPLEMENT: sodium butyrate|OTHER: placebo Details
EUCTR2013-001503-37-DK Effect of low-dose Azathioprine and Allopurinol compared to Azathioprine on clinical outcomes in Inflammatory Bowel Disease PHASE3 Not Recruiting Marianne Kiszka-Kanowitz Inflammatory Bowel Disease, (Ulcerativ colitis, C… Trade Name: Imurel Pharmaceutical Form: Tablet IN… Details
EUCTR2010-020448-37-NL Randomized placebo-controlled multicenter exploratory Phase IIA study to assess the safety and efficacy of PEG-liposomal prednisolone sodium phosphate (Nanocort) in subjects with active ulcerative colitis. Not Available Not Recruiting Enceladus Pharmaceuticals Active Ulcerative Colitis MedDRA version: 14.1_L… Product Name: PEG-liposomal prednisolone sodium p… Details
NCT00486031 Open-Label, Long-term Balsalziade Disodium Tablet Ulcerative Colitis Study PHASE3 COMPLETED Bausch Health Americas, Inc. Inflammatory Bowel Disease|Ulcerative Colitis DRUG: Balsalazide Disodium Details

Disease IDDisease NameDefinitionCategoryRelated DrugsMechanism
No data available

Strategy IDTherapeutic StrategySynonymsRelated DrugsMechanism
No data available

Safety and activity of dersalazine sodium in patients with mild-to-moderate act…

PMID: 25192498
Year: 2014
Relationship Type: Treatment Score: 9.3

BACKGROUND: Dersalazine sodium is an inhibitor of platelet activator factor with potential efficacy in patients with ulcerative colitis through an al…

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The intestinal anti-inflammatory effect of dersalazine sodium is related to a d…

PMID: 21790535
Year: 2012
Relationship Type: Association Score: 6.1

Intestinal dysbiosis is thought to confer susceptibility to inflammatory bowel disease (IBD), but it is unknown whether dynamic changes in the micro…

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