| Drug ID: | Drug190 |
|---|---|
| Drug Name: | Sulfasalazine |
| CID: | 5339 |
| DrugBank ID: | DB00795 |
| Modality: | Small Molecule |
| Groups: | approved |
| US Approved: | YES |
| Other Approved: | YES |
| Identifier: | NCT03414502, , NCT02714634, , NCT03254589, , NCT03739853, , NCT03847311, , NCT04720183, , NCT06060301, , NCT04725422, , NCT02451748, , NCT05580861, , NCT05664464, , NCT03561584, , NCT05703425, , NCT06360068, , NCT06134388, , NCT04205357, , NCT05445440, , NCT04610476, , NCT02374021, , NCT02466 |
| Molecular Formula: | C18H14N4O5S |
| Molecular Weight: | 398.4 g/mol |
| Isomeric SMILES: | C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O |
| Synonyms: | sulfasalazine; Salicylazosulfapyridine; Azulfidine; Sulphasalazine; Benzosulfa; Azopyrin; Sulfasalazina; Sulfasalazinum; Sulfasalazin; Azulfidine EN-tabs |
| Phase 0: | 1 |
| Phase 1: | 12 |
| Phase 2: | 13 |
| Phase 3: | 18 |
| Phase 4: | 20 |
| Description: | A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907) |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt1325 | 5339 | Sulfasalazine | 9308 | CD83 | Homo sapiens (human) | None | |
| dt1326 | 5339 | Sulfasalazine | 240 | ALOX5 | Homo sapiens (human) | Arachidonate 5-lipoxygenase inhibitor | |
| dt1327 | 5339 | Sulfasalazine | 1719 | DHFR | Homo sapiens (human) | None | |
| dt1328 | 5339 | Sulfasalazine | 3091 | HIF1A | Homo sapiens (human) | None | |
| dt1329 | 5339 | Sulfasalazine | 1576 | CYP3A4 | Homo sapiens (human) | None | |
| dt1330 | 5339 | Sulfasalazine | 5743 | PTGS2 | Homo sapiens (human) | None | |
| dt1331 | 5339 | Sulfasalazine | 5468 | PPARG | Homo sapiens (human) | None | |
| dt1332 | 5339 | Sulfasalazine | 38 | ACAT1 | Homo sapiens (human) | None | |
| dt1333 | 5339 | Sulfasalazine | 240 | ALOX5 | Homo sapiens (human) | Inhibitor | |
| dt1334 | 5339 | Sulfasalazine | 1544 | CYP1A2 | Homo sapiens (human) | None |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||
Scavenging of reactive oxygen and nitrogen species by the prodrug sulfasalazine…
PMID: 21208525
Year: 2010
Relationship Type:
Treatment
Score: 10.0
Sulfasalazine salicylazosulfapyridine (SASP), consisting of 5-aminosalicylic acid bound to sulfapyridine by a diazo bond, is an effective drug in th…
Meta-analysis and systematic review on Sulfasalazine/5-ASA use during pregnancy…
PMID: 40334871
Year: 2025
Relationship Type:
Treatment
Score: 9.5
OBJECTIVES: This study aims to evaluate the risks associated with Sulfasalazine (SSZ) and 5-aminosalicylic acid (5-ASA) use during pregnancy on perin…
Clinical outcomes of maintenance therapy with sulfasalazine compared to 5-amino…
PMID: 40205880
Year: 2025
Relationship Type:
Treatment
Score: 9.5
OBJECTIVES: Sulfasalazine (SZ) and 5-aminosalicylates (5-ASA) have been widely used treatments for ulcerative colitis (UC). Although some studies sug…
Application of Saccharomyces boulardii in combination with sulfasalazine in ulc…
PMID: 40061979
Year: 2025
Relationship Type:
Treatment
Score: 9.5
BACKGROUND: Ulcerative colitis (UC) is a complex inflammatory bowel disease, and its etiology and pathogenesis remain incompletely elucidated. AIM: T…
Resistant starch grafted cerium-sulfasalazine infinite coordination polymers sy…
PMID: 39707422
Year: 2024
Relationship Type:
Treatment
Score: 9.5
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease which is closely related with the overproduced reactive oxygen species (ROS), …
Sulfasalazine-Loaded Copper-Tannic Acid Coordination Nanozyme Enables ROS Scave…
PMID: 39648654
Year: 2024
Relationship Type:
Treatment
Score: 9.5
Inflammatory bowel disease (IBD) is associated with elevated levels of reactive oxygen species (ROS) and an increased expression of proinflammatory c…
Evaluation of the immunomodulatory activity of probiotics mixture and sulfasala…
PMID: 39419885
Year: 2024
Relationship Type:
Treatment
Score: 9.5
BACKGROUND: Currently, the use of probiotics to treat inflammatory bowel diseases (IBD) is widely accepted because of their gut microbiota modulation…
Co-amorphous systems of sulfasalazine with matrine-type alkaloids: Enhanced sol…
PMID: 39216557
Year: 2024
Relationship Type:
Treatment
Score: 9.5
Sulfasalazine (SULF), a sulfonamide antibiotic, has been utilized in the treatment of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) …
Combinatorial intervention with dental pulp stem cells and sulfasalazine in a r…
PMID: 39078564
Year: 2024
Relationship Type:
Treatment
Score: 9.5
BACKGROUND: Ulcerative colitis is an inflammatory bowel disease (IBD) that involves inflammation of the colon lining and rectum. Although a definitiv…
Formulation and Development of Novel Sulfasalazine Bilayer Tablets for The Trea…
PMID: 38401631
Year: 2024
Relationship Type:
Treatment
Score: 9.5
Sulfasalazine needs frequent daily dosing and the administration of numerous tablets per day pose challenges to patient compliance, contributing to i…
The gut microbiome regulates the clinical efficacy of sulfasalazine therapy for…
PMID: 38378002
Year: 2024
Relationship Type:
Treatment
Score: 9.5
Sulfasalazine is a prodrug known to be effective for the treatment of inflammatory bowel disease (IBD)-associated peripheral spondyloarthritis (pSpA)…
Comparative treatment of Sulfasalazine+Ezetimibe combination and Sulfasalazine …
PMID: 38024826
Year: 2023
Relationship Type:
Treatment
Score: 9.5
Ulcerative colitis is a chronic inflammatory disease with high mortality and morbidity worldwide. It causes inflammation in the lining of the colon, …
DRESS syndrome - A dermatological emergency - Sulfasalazine-related acute drug …
PMID: 37809745
Year: 2023
Relationship Type:
Association
Score: 9.5
Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) or drug-induced hypersensitivity syndrome (DIHS) is a severe skin reaction ass…
Sulfasalazine as a cause of false-positive elevation of urinary normetanephrine…
PMID: 37730424
Year: 2023
Relationship Type:
Treatment
Score: 9.5
In patients with suspected phaeochromocytoma, biochemical screening of urine or blood for excess secretion catecholamines and/or their metabolites is…
Genistein and/or sulfasalazine ameliorate acetic acid-induced ulcerative coliti…
PMID: 37414101
Year: 2023
Relationship Type:
Treatment
Score: 9.5
Ulcerative Colitis (UC) is a chronic idiopathic inflammatory bowel disease in which the colon's lining becomes inflamed. Exploring herbal remedies th…
Repurposing Sulfasalazine as a Radiosensitizer in Hypoxic Human Colorectal Canc…
PMID: 37190291
Year: 2023
Relationship Type:
Treatment
Score: 9.5
xCT overexpression in cancer cells has been linked to tumor growth, metastasis and treatment resistance. Sulfasalazine (SSZ), an FDA-approved drug fo…
Sulfasalazine exposure during pregnancy and lactation: reproductive outcomes in…
PMID: 37080254
Year: 2023
Relationship Type:
Treatment
Score: 9.5
CONTEXT: Sulfasalazine (SAS) is a drug prescribed for pregnant and breastfeeding women with chronic inflammatory bowel diseases. SAS treatment induce…
Efficacy and Safety of Sulfasalazine Suspension in Children With Ulcerative Col…
PMID: 36576855
Year: 2023
Relationship Type:
Treatment
Score: 9.5
BACKGROUND: Sulfasalazine (SZ) is commonly used to treat pediatric ulcerative colitis (UC). SZ can be compounded into a suspension form which is bene…
Drug hypersensitivity syndrome induced by sulfasalazine: A case report
PMID: 35984191
Year: 2022
Relationship Type:
Treatment
Score: 9.5
INTRODUCTION: Drug hypersensitivity syndrome (DHS) induced by sulfasalazine is a serious systemic delayed adverse drug reaction, which is associated …
Iron plays a role in sulfasalazine-induced ferroptosis with autophagic flux blo…
PMID: 35441682
Year: 2022
Relationship Type:
Treatment
Score: 9.5
Osteosarcoma is the most common primary bone malignancy in children and young adults, with a very poor prognosis. It is of great importance to develo…