| Drug ID: | Drug190 |
|---|---|
| Drug Name: | Sulfasalazine |
| CID: | 5339 |
| DrugBank ID: | DB00795 |
| Modality: | Small Molecule |
| Groups: | approved |
| US Approved: | YES |
| Other Approved: | YES |
| Identifier: | NCT03414502, , NCT02714634, , NCT03254589, , NCT03739853, , NCT03847311, , NCT04720183, , NCT06060301, , NCT04725422, , NCT02451748, , NCT05580861, , NCT05664464, , NCT03561584, , NCT05703425, , NCT06360068, , NCT06134388, , NCT04205357, , NCT05445440, , NCT04610476, , NCT02374021, , NCT02466 |
| Molecular Formula: | C18H14N4O5S |
| Molecular Weight: | 398.4 g/mol |
| Isomeric SMILES: | C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O |
| Synonyms: | sulfasalazine; Salicylazosulfapyridine; Azulfidine; Sulphasalazine; Benzosulfa; Azopyrin; Sulfasalazina; Sulfasalazinum; Sulfasalazin; Azulfidine EN-tabs |
| Phase 0: | 1 |
| Phase 1: | 12 |
| Phase 2: | 13 |
| Phase 3: | 18 |
| Phase 4: | 20 |
| Description: | A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907) |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt1325 | 5339 | Sulfasalazine | 9308 | CD83 | Homo sapiens (human) | None | |
| dt1326 | 5339 | Sulfasalazine | 240 | ALOX5 | Homo sapiens (human) | Arachidonate 5-lipoxygenase inhibitor | |
| dt1327 | 5339 | Sulfasalazine | 1719 | DHFR | Homo sapiens (human) | None | |
| dt1328 | 5339 | Sulfasalazine | 3091 | HIF1A | Homo sapiens (human) | None | |
| dt1329 | 5339 | Sulfasalazine | 1576 | CYP3A4 | Homo sapiens (human) | None | |
| dt1330 | 5339 | Sulfasalazine | 5743 | PTGS2 | Homo sapiens (human) | None | |
| dt1331 | 5339 | Sulfasalazine | 5468 | PPARG | Homo sapiens (human) | None | |
| dt1332 | 5339 | Sulfasalazine | 38 | ACAT1 | Homo sapiens (human) | None | |
| dt1333 | 5339 | Sulfasalazine | 240 | ALOX5 | Homo sapiens (human) | Inhibitor | |
| dt1334 | 5339 | Sulfasalazine | 1544 | CYP1A2 | Homo sapiens (human) | None |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||
Dapsone Azo-Linked with Two Mesalazine Moieties Is a "Me-Better" Alternative to…
PMID: 35336057
Year: 2022
Relationship Type:
Treatment
Score: 9.5
Dapsone (DpS) is an antimicrobial and antiprotozoal agent, especially used to treat leprosy. The drug shares a similar mode of action with sulfonamid…
Sulfasalazine exposure during pregnancy and lactation induces alterations in re…
PMID: 35051419
Year: 2022
Relationship Type:
Treatment
Score: 9.5
AIMS: Sulfasalazine (SAS) is the first line drug in the treatment of chronic inflammatory bowel diseases in pregnant women. SAS and its metabolites c…
Radiosynthesis and in silico bioevaluation of (131) I-Sulfasalazine as a highly…
PMID: 34314572
Year: 2021
Relationship Type:
Treatment
Score: 9.5
This study demonstrated the tracking of ulcerative colitis, which is considered a stressful immune disease. Although there are many ways to test for …
Sulfasalazine maintains blood-brain barrier integrity and relieves lipopolysacc…
PMID: 33913929
Year: 2021
Relationship Type:
Treatment
Score: 9.5
Sulfasalazine is a recognized therapy for inflammatory bowel disease and is of paramount importance for maintaining intestinal barrier homeostasis. H…
Drug-Drug Compatibility Evaluation of Sulfasalazine and Folic Acid for Fixed-Do…
PMID: 33802955
Year: 2021
Relationship Type:
Treatment
Score: 9.5
The simultaneous administration of sulfasalazine and folic acid is regular practice in the therapy of inflammatory bowel diseases in order to maintai…
The beneficial effect of combination therapy with sulfasalazine and valsartan i…
PMID: 33628160
Year: 2021
Relationship Type:
Treatment
Score: 9.5
Gut microorganisms metabolize azobenzene compounds (Ph1 -N=N-Ph2 ) into free aniline products (Ph1 -NH2 +H2 N-Ph2 ), a process that has been largely…
Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhi…
PMID: 33428896
Year: 2021
Relationship Type:
Treatment
Score: 9.5
Diurnal variations in pain hypersensitivity are common in chronic pain disorders. Temporal exacerbation of neuropathic pain hypersensitivity is depen…
New approach of medicinal herbs and sulfasalazine mixture on ulcerative colitis…
PMID: 32994687
Year: 2020
Relationship Type:
Treatment
Score: 9.5
BACKGROUND: Sulfasalazine has been used as a standard-of-care in ulcerative colitis for decades, however, it results in severe adverse symptoms, such…
Influences of probiotics combined with sulfasalazine on rats with ulcerative co…
PMID: 31364145
Year: 2019
Relationship Type:
Treatment
Score: 9.5
OBJECTIVE: To investigate the influences of probiotics combined with sulfasalazine (SASP) on the expression of the Wnt/beta-catenin signaling pathway…
Sulfasalazine-Induced Interstitial Fibrosis
PMID: 30515045
Year: 2018
Relationship Type:
Treatment
Score: 9.3
Sulfasalazine has been used in the treatment of inflammatory bowel disease for over 60 years. Although the drug is frequently associated with gastroi…
5-ASA to sulfasalazine drug switch program in patients with ulcerative colitis
PMID: 30020742
Year: 2018
Relationship Type:
Adverse Effect
Score: 9.3
OBJECTIVES: To switch patients with ulcerative colitis (UC) from costlier 5-aminosalicylic acid compounds to sulfasalazine and assess (1) the cost sa…
Sulfasalazine induces mitochondrial dysfunction and renal injury
PMID: 29214868
Year: 2017
Relationship Type:
Treatment
Score: 9.3
Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory bowel disease. There are several cases of renal inju…
Comparative Evaluation between Sulfasalazine Alone and in Combination with Herb…
PMID: 29018816
Year: 2017
Relationship Type:
Treatment
Score: 9.3
The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and sulfasalazine in combin…
Comparative Effectiveness of Mesalamine, Sulfasalazine, Corticosteroids, and Bu…
PMID: 28146003
Year: 2017
Relationship Type:
Treatment
Score: 9.3
BACKGROUND: Induction treatment of mild-to-moderate Crohn's disease is controversial. PURPOSE: To compare the induction of remission between differen…
Sulfasalazine: A rare cause of acute eosinophilic pneumonia
PMID: 27144116
Year: 2016
Relationship Type:
Treatment
Score: 9.3
Sulfasalazine is a compound of 5-aminosalicylic acid (5-ASA) and sulfapyridine joined by an azo bond. It is a widely used drug in the treatment of ch…
Promotion of Remyelination by Sulfasalazine in a Transgenic Zebrafish Model of …
PMID: 26549504
Year: 2015
Relationship Type:
Treatment
Score: 9.3
Most of the axons in the vertebrate nervous system are surrounded by a lipid-rich membrane called myelin, which promotes rapid conduction of nerve im…
Mesalamine, but Not Sulfasalazine, Reduces the Risk of Colorectal Neoplasia in …
PMID: 26296062
Year: 2015
Relationship Type:
Association
Score: 9.3
BACKGROUND: In some studies, 5-aminosalicylates as a class have been associated with protective effects against colorectal cancer in inflammatory bow…
Sulfasalazine
PMID: 31644099
Year: 2012
Relationship Type:
Treatment
Score: 9.1
Sulfasalazine is an antiinflammatory agent used extensively in chronic, long term therapy of inflammatory bowel disease. Sulfasalazine is structurall…
Sulfasalazine induced lung toxicity masquerading as sarcoidosis--case report an…
PMID: 24284297
Year: 2013
Relationship Type:
Treatment
Score: 9.1
A commonly prescribed drug for Rheumatoid Arthritis (R.A) and Inflammatory Bowel Disease (IBD) treatment, Sulfasalazine can occasionally cause lung t…
[Rescue therapy with sulfasalazine prior to immunosuppressive or biological age…
PMID: 23195755
Year: 2013
Relationship Type:
Treatment
Score: 9.1
INTRODUCTION: In ulcerative colitis, aminosalicylates are the mainstay of maintenance therapy. Sulfasalazine was the first aminosalicylic used in the…