Drug ID:Drug195
Drug Name:Gamolenic acid
CID:5280933
DrugBank ID:DB13854
Modality:Small Molecule
Groups:NULL
US Approved:NO
Other Approved:YES
Identifier: NCT04481724, , NCT03914404, , NCT00004420
Molecular Formula:C18H30O2
Molecular Weight:278.4 g/mol
Isomeric SMILES:CCCCC/C=C\\C/C=C\\C/C=C\\CCCCC(=O)O
Synonyms:gamma-Linolenic acid; GAMOLENIC ACID; 506-26-3; (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid; (Z,Z,Z)-6,9,12-Octadecatrienoic acid; gamma Linolenic Acid; Ligla; Acido gamolenico; (6,9,12)-linolenic acid; Acide gamolenique
Phase 0: 0
Phase 1: 0
Phase 2: 0
Phase 3: 0
Phase 4: 0
Description:NULL

Molecular Structure

2D Molecular Structure

Knowledge Graph

dtIDCIDCompound NameGene IDGene NameSpeciesPubMed IDsAction
dt1365 5280933 gamma-Linolenic acid 6286 S100P Homo sapiens (human) 20664735 Gamma-linolenic acid results in increased expression of S100P mRNA
dt1366 5280933 gamma-Linolenic acid 5743 PTGS2 Homo sapiens (human) 17092368 Gamma-linolenic acid results in increased expression of PTGS2 mRNA
dt1367 5280933 gamma-Linolenic acid 5468 PPARG Homo sapiens (human) 15318936 Gamma-linolenic acid binds to and results in increased activity of PPARG protein
dt1368 5280933 gamma-Linolenic acid 5468 PPARG Oryctolagus cuniculus (rabbit) 25560393 Gamma-linolenic acid results in increased expression of PPARG mRNA
dt1369 5280933 gamma-Linolenic acid 22949 PTGR1 Homo sapiens (human) 20664735 Gamma-linolenic acid results in increased expression of PTGR1 mRNA
dt1370 5280933 gamma-Linolenic acid 6502 SKP2 Homo sapiens (human) 20664735 Gamma-linolenic acid results in decreased expression of SKP2 mRNA
dt1371 5280933 gamma-Linolenic acid 6520 SLC3A2 Homo sapiens (human) 20664735 Gamma-linolenic acid results in increased expression of SLC3A2 mRNA
dt1372 5280933 gamma-Linolenic acid 5465 PPARA Homo sapiens (human) 10403814 Gamma-linolenic acid binds to and results in increased activity of PPARA protein
dt1373 5280933 gamma-Linolenic acid 1645 AKR1C1 Homo sapiens (human) 20664735 Gamma-linolenic acid results in increased expression of AKR1C1 mRNA
dt1374 5280933 gamma-Linolenic acid 1109 AKR1C4 Homo sapiens (human) 20664735 Gamma-linolenic acid results in increased expression of AKR1C4 mRNA

  • No data available

Phase Distribution
Phase Description
  • Phase 0: Exploratory trials to assess drug behavior in humans
  • Phase 1: Safety trials to determine safe dosage range
  • Phase 2: Efficacy trials to evaluate therapeutic effects
  • Phase 3: Large-scale trials to confirm efficacy and safety
  • Phase 4: Post-marketing surveillance for long-term safety and efficacy

Trial IDTitlePhaseStatusSponsorIndicationsInterventions
NCT00787202 A Study To Investigate The Safety And Efficacy Of CP- 690,550 In Patients With Moderate And Severe Ulcerative Colitis. PHASE2 COMPLETED Pfizer Ulcerative Colitis DRUG: CP- 690 550|DRUG: CP- 690 550|DRUG: CP- 690… Details
NCT06321887 EffiCacy and sAfEty of Low doSe orAl iRon for Anaemia in IBD PHASE3 RECRUITING Liverpool University Hospitals NHS Foundation Trust Inflammatory Bowel Disease|Iron Deficiency Anemia DRUG: Ferrous fumarate syrup 2.5ml/70mg (22.5mg e… Details
NCT02762500 An Efficacy and Safety Study of LYC-30937-EC in Subjects With Active Ulcerative Colitis PHASE2 COMPLETED Lycera Corp. Colitis, Ulcerative DRUG: LYC-30937-EC|DRUG: Placebo Details
NCT03943550 Double-Blinded, Placebo-Controlled Phase 1b Study for Safety, PK, Efficacy, PD of RO7049665 in Participants With Ulcerative Colitis (UC) PHASE1 TERMINATED Hoffmann-La Roche Ulcerative Colitis DRUG: RO7049665|DRUG: Placebo Details
NCT02392221 Impact of Therapeutic Strategies in the Pediatric Inflammatory Bowel Disease: a Population Based Study (1988-2011). None COMPLETED Centre Hospitalier Universitaire, Amiens Pediatric Inflammatory Bowel Disease None Details
NCT01465763 A Study Evaluating The Efficacy And Safety Of CP-690,550 In Patients With Moderate To Severe Ulcerative Colitis PHASE3 COMPLETED Pfizer Ulcerative Colitis DRUG: tofacitinib|DRUG: Placebo Details
NCT01100112 (CB-01-02/06) Oral Budesonide-Multi-Matrix System (MMX) 9mg Extended Release Tablets PHASE3 COMPLETED Bausch Health Americas, Inc. Colitis, Ulcerative DRUG: Budesonide Details
NCT06636656 A Study to Test Whether BI 3032950 Helps People With Ulcerative Colitis PHASE2 RECRUITING Boehringer Ingelheim Ulcerative Colitis DRUG: BI 3032950 intravenous (Part A)|DRUG: BI 30… Details
NCT01458951 A Study To Evaluate Both The Efficacy and Safety Profile of CP-690,550 In Patients With Moderately to Severely Active Ulcerative Colitis PHASE3 COMPLETED Pfizer Ulcerative Colitis DRUG: tofacitinib|DRUG: Placebo Details
NCT02318667 Correlation of Soluble Suppression of Tumorigenicity 2 (ST2) With Golimumab (MK-8259) Response in Participants With Ulcerative Colitis (UC) (MK-8529-022). PHASE4 COMPLETED Merck Sharp & Dohme LLC Colitis, Ulcerative BIOLOGICAL: Golimumab Details
NCT01470612 Long-Term Study Of CP-690,550 In Subjects With Ulcerative Colitis PHASE3 COMPLETED Pfizer Ulcerative Colitis DRUG: CP-690,550|DRUG: CP-690,550 Details
NCT02493712 A Phase 2a, Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled Trial of IBD98-M PHASE2 COMPLETED Holy Stone Healthcare Co., Ltd Colitis, Ulcerative DRUG: High dose|DRUG: Low dose|DRUG: Placebo Details
NCT06786507 A Direct Head-to-head Comparison of Ustekinumab with Infliximab for the Treatment of Ulcerative Colitis None NOT_YET_RECRUITING Helwan University Ulcerative Colitis (UC) DRUG: Ustekinumab 90 mg|DRUG: Infliximab Details
NCT06260267 A Phase 1b Proof-of-concept Trial Exploring the Effects of FE 999322 and FE 999324 in Adults With Mild to Moderate Ulcerative Colitis PHASE1 WITHDRAWN Ferring Pharmaceuticals Ulcerative Colitis DRUG: Microbiota suspension|DRUG: Microbiota caps… Details
NCT02246686 Efficacy/Safety Pilot Study to Investigate Iberogast N's Efficacy in Mild to Moderate Colitis Ulcerosa Patients PHASE2 TERMINATED Bayer Colitis, Ulcerative DRUG: STW5-II (Iberogast N, BAY98-7410)|DRUG: Pla… Details
NCT04969679 Additive Effect of Probiotics (Mutaflor) in Patients With Ulcerative Colitis on 5-ASA Treatment. PHASE4 COMPLETED Kangbuk Samsung Hospital Ulcerative Colitis DRUG: E. coli Nissle 1917 (Mutaflor)|DRUG: Placebo Details
NCT00355901 An Observational Follow-up Study for Subjects Receiving Salvage Therapy After Previous Treatment in a Visilizumab Study for Intravenous Steroid-Refractory Ulcerative Colitis None TERMINATED PDL BioPharma, Inc. Ulcerative Colitis DRUG: Visilizumab (Nuvion; HuM291) Details
NCT01036022 Effect of GSK1399686 in Patients With Mild to Moderately Active Ulcerative Colitis PHASE2 COMPLETED GlaxoSmithKline Colitis, Ulcerative DRUG: GSK1399686 Details
NCT04411784 PROTECT-ASUC: Covid-19 Pandemic Response Of assessmenT, EndosCopy and Treatment in Acute Severe Ulcerative Colitis None COMPLETED Hull University Teaching Hospitals NHS Trust Inflammatory Bowel Diseases|COVID None Details
NCT01320332 A Study of a Single Dose of ASP3291 in Subjects With Ulcerative Colitis PHASE1 COMPLETED Telsar Pharma Inc. Ulcerative Colitis DRUG: ASP3291|DRUG: Placebo Details

Disease IDDisease NameDefinitionCategoryRelated DrugsMechanism
No data available

Strategy IDTherapeutic StrategySynonymsRelated DrugsMechanism
S02 Immunosuppression Classic immunosuppressive drugs azathioprine; 6-mercaptopurine; methotrexate; ciclosporin-A; tacrolimus Ciclosporin-A and tacrolimus bind to specific intracellular… Details
S03 Anti-TNF agents Tumor necrosis factor infliximab; adalimumab; golimumab; certolizumab pegol TNF is produced by various immune and non-immune cells in t… Details
S04 T-cell homing and retention T-cell trafficking vedolizumab; anti-MAdCAM1 antibodies ; etrolizumab Inhibition of the interaction between α4β7 integrins on T c… Details
S05 Angiogenesis cell proliferation; vascular permeability ozanimod The bioactive lipid S1P has been shown to activate NF-κB an… Details
S07 Blockade of cytokine Cytokine signalling apremilast; roflumilast; filgotinib; tofacitinib; ABT494; ABT-874; ustekinumab; isankizumab; LY-2525623; AMG139; MEDI2079; guselkumab Various T-cell subsets, their differentiation pathways and … Details

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