Drug ID:Drug195
Drug Name:Gamolenic acid
CID:5280933
DrugBank ID:DB13854
Modality:Small Molecule
Groups:NULL
US Approved:NO
Other Approved:YES
Identifier: NCT04481724, , NCT03914404, , NCT00004420
Molecular Formula:C18H30O2
Molecular Weight:278.4 g/mol
Isomeric SMILES:CCCCC/C=C\\C/C=C\\C/C=C\\CCCCC(=O)O
Synonyms:gamma-Linolenic acid; GAMOLENIC ACID; 506-26-3; (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid; (Z,Z,Z)-6,9,12-Octadecatrienoic acid; gamma Linolenic Acid; Ligla; Acido gamolenico; (6,9,12)-linolenic acid; Acide gamolenique
Phase 0: 0
Phase 1: 0
Phase 2: 0
Phase 3: 0
Phase 4: 0
Description:NULL

Molecular Structure

2D Molecular Structure

Knowledge Graph

dtIDCIDCompound NameGene IDGene NameSpeciesPubMed IDsAction
dt1365 5280933 gamma-Linolenic acid 6286 S100P Homo sapiens (human) 20664735 Gamma-linolenic acid results in increased expression of S100P mRNA
dt1366 5280933 gamma-Linolenic acid 5743 PTGS2 Homo sapiens (human) 17092368 Gamma-linolenic acid results in increased expression of PTGS2 mRNA
dt1367 5280933 gamma-Linolenic acid 5468 PPARG Homo sapiens (human) 15318936 Gamma-linolenic acid binds to and results in increased activity of PPARG protein
dt1368 5280933 gamma-Linolenic acid 5468 PPARG Oryctolagus cuniculus (rabbit) 25560393 Gamma-linolenic acid results in increased expression of PPARG mRNA
dt1369 5280933 gamma-Linolenic acid 22949 PTGR1 Homo sapiens (human) 20664735 Gamma-linolenic acid results in increased expression of PTGR1 mRNA
dt1370 5280933 gamma-Linolenic acid 6502 SKP2 Homo sapiens (human) 20664735 Gamma-linolenic acid results in decreased expression of SKP2 mRNA
dt1371 5280933 gamma-Linolenic acid 6520 SLC3A2 Homo sapiens (human) 20664735 Gamma-linolenic acid results in increased expression of SLC3A2 mRNA
dt1372 5280933 gamma-Linolenic acid 5465 PPARA Homo sapiens (human) 10403814 Gamma-linolenic acid binds to and results in increased activity of PPARA protein
dt1373 5280933 gamma-Linolenic acid 1645 AKR1C1 Homo sapiens (human) 20664735 Gamma-linolenic acid results in increased expression of AKR1C1 mRNA
dt1374 5280933 gamma-Linolenic acid 1109 AKR1C4 Homo sapiens (human) 20664735 Gamma-linolenic acid results in increased expression of AKR1C4 mRNA

  • No data available

Phase Distribution
Phase Description
  • Phase 0: Exploratory trials to assess drug behavior in humans
  • Phase 1: Safety trials to determine safe dosage range
  • Phase 2: Efficacy trials to evaluate therapeutic effects
  • Phase 3: Large-scale trials to confirm efficacy and safety
  • Phase 4: Post-marketing surveillance for long-term safety and efficacy

Trial IDTitlePhaseStatusSponsorIndicationsInterventions
NCT05706038 Impact of Adalimumab Withdrawal or Continuation on Severity of COVID-19 and Risk of IMID Relapse NULL COMPLETED IRCCS San Raffaele Inflammatory Bowel Diseases|Rheumatic Disorder DRUG: Adalimumab Details
NCT05688852 VTX958 for the Treatment of Moderately to Severely Active Crohn's Disease PHASE2 TERMINATED Ventyx Biosciences, Inc Crohn Disease DRUG: VTX958|DRUG: VTX958|DRUG: VTX958 Placebo Details
NCT05687474 Baby Detect : Genomic Newborn Screening NULL COMPLETED Centre Hospitalier Universitaire de Liege Congenital Adrenal Hyperplasia|Familial Hyperinsu… None Details
NCT05686135 90Second IBD for the Improvement of Self Efficacy and Quality of Life in Inflammatory Bowel Disease Patients NA WITHDRAWN Jennifer Jones IBD|Crohn Disease|Ulcerative Colitis OTHER: 90Second IBD Details
NCT05668104 Jing Si Herbal Tea for Long-Coronavirus Disease(COVID) Gut-brain Interaction NA COMPLETED Buddhist Tzu Chi General Hospital Healthy Subjects|COVID-19 Pneumonia|Irritable Bow… DIETARY_SUPPLEMENT: Jing Si Herbal Tea Liquid Pac… Details
NCT05584735 Determining the Relationship Between Gut Microbiota and Immune Response to Influenza or COVID-19 Vaccine NULL COMPLETED University of Wisconsin, Madison Inflammatory Bowel Diseases BIOLOGICAL: Influenza vaccine|BIOLOGICAL: COVID-1… Details
NCT05549323 A Study to Learn About the Safety, Effects and Pharmacokinetics of Study Medication (PF-07054894) for the Treatment of Ulcerative Colitis PHASE1 TERMINATED Pfizer Ulcerative Colitis DRUG: PF-07054894|DRUG: Placebo Details
NCT05452304 AZD7798 Safety, Tolerability, and Pharmacokinetics After a Single Ascending and Repeat Dose Administrations to Healthy Subjects, and Patients With Crohn's Disease PHASE1 COMPLETED AstraZeneca Healthy Subjects|Crohns Disease BIOLOGICAL: AZD7798|BIOLOGICAL: Placebo Details
NCT05389709 A Pharmacy-based Observational Study to Learn More About Iberogast Advance in the Real-world Setting NULL COMPLETED Bayer Functional Gastrointestinal Disorders Such as Irr… DRUG: Iberogast (STW5-II, BAY98-7410) Details
NCT07149441 Efficacy and Mechanism of FMT in the Treatment of Inflammatory Bowel Disease: an Open-label Randomized Controlled Study NA ACTIVE_NOT_RECRUITING Shanghai 10th People's Hospital Inflammatory Bowel Disease (Crohn&Amp;#39;s Disea… PROCEDURE: Fecal microbiota transplantation|DRUG:… Details
NCT07132333 Molecular Inflammation Board at the Center for Personalized Medicine NULL RECRUITING University Hospital Tuebingen Psoriasis (PsO)|Psoriasis Arthritis|Inflammatory … BIOLOGICAL: Biologic Agent Details
NCT05242484 A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis PHASE2 ACTIVE_NOT_RECRUITING Janssen Research & Development, LLC Colitis, Ulcerative BIOLOGICAL: Guselkumab|BIOLOGICAL: Golimumab|BIOL… Details
NCT05242471 A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease PHASE2 ACTIVE_NOT_RECRUITING Janssen Research & Development, LLC Crohn's Disease BIOLOGICAL: Guselkumab|BIOLOGICAL: Golimumab|BIOL… Details
NCT05240521 Efficacy and Safety, Tolerability of GA-AT0119 in IBS-C NA UNKNOWN Devintec Sagl Irritable Bowel Syndrome With Constipation (IBS-C) OTHER: ARM A|OTHER: ARM B Details
NCT07125625 Probiotic Mixture (L. Rhamnosus GG and L. Plantarum 299V) In Pediatric Irritable Bowel Syndrome NA NOT_YET_RECRUITING University of Bari Irritable Bowel Syndrome (IBS) DIETARY_SUPPLEMENT: Experimental arm: probiotic|D… Details
NCT07123350 Evaluating the Shift From Intravenous to Subcutaneous Vedolizumab for Inflammatory Bowel Disease NULL ACTIVE_NOT_RECRUITING Vanderbilt University Medical Center Inflammatory Bowel Disease (IBD)|Crohn&Amp;#39;s … DRUG: Patient switched from IV vedolizumab to sub… Details
NCT05153850 Assessment of the Response to the Complete Vaccination Guidelines Against Sars-cov2 NULL UNKNOWN Fundación Pública Andaluza para la gestión de la Investigación en Sevilla COVID-19 None Details
NCT05115370 Vaccination Perception in Inflammatory Conditions - Flu, Pneumonia and COVID-19 NULL COMPLETED University of Nottingham Inflammatory Disease|Rheumatoid Arthritis|Psoriat… OTHER: Semi-structured qualitative interview Details
NCT07421011 Pharmacokinetics, Bioequivalence, and Safety Study of Trimedat® 76,95 mg Orally Disintegrating Tablets and Trimedat® 100 mg Tablets in Healthy Volunteers. PHASE1 RECRUITING Valenta Pharm JSC Irritable Bowel Syndrome|Gallstone Disease|GERD|B… DRUG: Trimedat® Details
NCT05098600 The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic NULL COMPLETED Faculty Hospital Kralovske Vinohrady Alopecia Areata|Alopecia Totalis|Alopecia Univers… OTHER: Exposure of interest Details

Disease IDDisease NameDefinitionCategoryRelated DrugsMechanism
No data available

Strategy IDTherapeutic StrategySynonymsRelated DrugsMechanism
S02 Immunosuppression Classic immunosuppressive drugs azathioprine; 6-mercaptopurine; methotrexate; ciclosporin-A; tacrolimus Ciclosporin-A and tacrolimus bind to specific intracellular… Details
S03 Anti-TNF agents Tumor necrosis factor infliximab; adalimumab; golimumab; certolizumab pegol TNF is produced by various immune and non-immune cells in t… Details
S04 T-cell homing and retention T-cell trafficking vedolizumab; anti-MAdCAM1 antibodies ; etrolizumab Inhibition of the interaction between α4β7 integrins on T c… Details
S05 Angiogenesis cell proliferation; vascular permeability ozanimod The bioactive lipid S1P has been shown to activate NF-κB an… Details
S07 Blockade of cytokine Cytokine signalling apremilast; roflumilast; filgotinib; tofacitinib; ABT494; ABT-874; ustekinumab; isankizumab; LY-2525623; AMG139; MEDI2079; guselkumab Various T-cell subsets, their differentiation pathways and … Details

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