Drug ID:Drug2
Drug Name:Macrogol
CID:174
DrugBank ID:DB09287
Modality:Small Molecule
Groups:NULL
US Approved:YES
Other Approved:YES
Identifier: NCT03395548
Molecular Formula:C2H6O2
Molecular Weight:62.07 g/mol
Isomeric SMILES:C(CO)O
Synonyms:ETHYLENE GLYCOL; Ethane-1,2-diol; 1,2-ethanediol; 107-21-1; monoethylene glycol; 1,2-Dihydroxyethane; 2-hydroxyethanol; Glycol alcohol; Ethylene alcohol; Fridex
Phase 0: 3
Phase 1: 11
Phase 2: 32
Phase 3: 47
Phase 4: 97
Description:NULL

Molecular Structure

2D Molecular Structure

Knowledge Graph

dtIDCIDCompound NameGene IDGene NameSpeciesPubMed IDsAction
dt2 174 Ethylene Glycol 9056 SLC7A7 Homo sapiens (human) 24888373 [ormosil binds to polyethylene glycols] which results in decreased expression of SLC7A7 mRNA
dt3 174 Ethylene Glycol 6590 SLPI Homo sapiens (human) 24888373 [ormosil binds to polyethylene glycols] which results in decreased expression of SLPI mRNA
dt4 174 Ethylene Glycol 10051 SMC4 Mus musculus (house mouse) 19695318 [gold co-treated with polyethylene glycols] results in decreased expression of SMC4 mRNA
dt5 174 Ethylene Glycol 79677 SMC6 Mus musculus (house mouse) 19695318 [gold co-treated with polyethylene glycols] results in decreased expression of SMC6 mRNA
dt6 174 Ethylene Glycol 54498 SMOX Homo sapiens (human) 24888373 [ormosil binds to polyethylene glycols] which results in increased expression of SMOX mRNA
dt7 174 Ethylene Glycol 6647 SOD1 Bos taurus (cattle) 17070914 Polyethylene glycols promotes the reaction [copper results in increased activity of SOD1 protein]
dt8 174 Ethylene Glycol 6647 SOD1 Mus musculus (house mouse) 19695318 [gold co-treated with polyethylene glycols] results in decreased expression of SOD1 mRNA
dt9 174 Ethylene Glycol 389058 SP5 Homo sapiens (human) 24888373 [ormosil binds to polyethylene glycols] which results in increased expression of SP5 mRNA
dt10 174 Ethylene Glycol 8877 SPHK1 Homo sapiens (human) 24888373 [ormosil binds to polyethylene glycols] which results in increased expression of SPHK1 mRNA
dt11 174 Ethylene Glycol 90853 SPOCD1 Homo sapiens (human) 24888373 [ormosil binds to polyethylene glycols] which results in increased expression of SPOCD1 mRNA

  • No data available

Phase Distribution
Phase Description
  • Phase 0: Exploratory trials to assess drug behavior in humans
  • Phase 1: Safety trials to determine safe dosage range
  • Phase 2: Efficacy trials to evaluate therapeutic effects
  • Phase 3: Large-scale trials to confirm efficacy and safety
  • Phase 4: Post-marketing surveillance for long-term safety and efficacy

Trial IDTitlePhaseStatusSponsorIndicationsInterventions
NCT03395548 Stability of the Microbiome in IBD and IBS None COMPLETED Medical University of Graz Microbiota DRUG: Macrogol Details
EUCTR2018-001402-28-ES PROTOCOL FOR THE OPTIMIZATION OF THE PREPARATION FOR THE COLONOSCOPY IN PATIENTS WITH INTESTINAL INFLAMMATORY DISEASE PHASE4 Authorised Hospital Universitario La Paz preparation in patients with inflammatory bowel d… Trade Name: Moviprep Sabor Naranja … Details
EUCTR2012-004214-34-IT Comparison of efficacy and acceptability of bisacodil and PEG-CS 2 L and PEG 4 L in patients with chronic inflammatory bowel disease: single center, randomized, single blind, parallel groups study Not Available Authorised AZIENDA OSPEDALIERA L. SACCO (A.O. DI RILIEVO NAZIONALE) IBD patients undergoing a colonoscopy. MedDRA ve… Trade Name: LOVOLDYL*30CPR RIV 5MG Pharmaceutical… Details
NCT01929668 Comparison of 4L Polyethylene Glycol and 2L Polyethylene Glycol With Ascorbic Acid in Inactive UC Patients None COMPLETED Kyungpook National University Hospital Ulcerative Colitis DRUG: polyethylene glycol|DRUG: Ascorbic Acid Details
NCT03581149 Tolerability and Efficacy of Sodium Picosulfate/Magnesium Citrate Versus PEG/Ascorbic Acid in Ulcerative Colitis Patients PHASE4 UNKNOWN American University of Beirut Medical Center Ulcerative Colitis DRUG: Sodium Picosulfate/Magnesium Citrate Laxati… Details
NCT02765256 Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease PHASE2 COMPLETED University of Pennsylvania Crohn's Disease DRUG: Fluconazole|DRUG: Vancomycin|DRUG: Neomycin… Details
NCT02009202 Preparation Prior to Colonoscopy in Children None COMPLETED Skane University Hospital Inflammatory Bowel Diseases DRUG: polyethylene glycol; DRUG: picosulphate Details
NCT05726097 Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure PHASE3 COMPLETED Region Skane Colon Cancer; Inflammatory Bowel Diseases; Gastro… DRUG: polyethylene glycol; DRUG: sodium phosphate… Details
NCT03042091 Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery EARLY_PHASE1 UNKNOWN Thomas Jefferson University Colorectal Neoplasms; Diverticulitis; Inflammator… DRUG: Polyethylene Glycol; DRUG: Neomycin; DRUG: … Details
ChiCTR2500097769 Clinical study on optimization plan for children's intestinal preparation Not Available Recruiting Shenzhen Children's Hospital inflammatory bowel disease A group:Preparation method for high-dose and divi… Details
CTIS2023-507425-42-00 A Prospective, Randomized, Placebo-controlled Clinical Trial of oral vancomycin in adults and young adults (15-17 years old) affected by Primary Sclerosing Cholangitis with or without Inflammatory Bowel Disease - VanC-IT PHASE2 Not Recruiting University Of Milano Bicocca Primary Sclerosing Cholangitis MedDRA version: 2… Product Name: , Product Code:SCP32734155, Pharmac… Details
CTRI/2023/09/057436 A randomized control trial to assess the effectiveness of a brief educational intervention on colonoscopy preparation and experience in patients with inflammatory bowel disease - NIL Not Available Not Recruiting Postgraduate Institute of Medical Education and research Health Condition 1: K50- Crohns disease [regional… Intervention1: Brief educational intervention: Ap… Details
NCT05878639 Evaluate Lactulose for Bowel Preparation in Patients With Inflammatory Bowel Disease Not Available Not recruiting Second Affiliated Hospital of Wenzhou Medical University IBD Drug: 3 bottles of Lactulose oral solution;Drug: … Details
ChiCTR2200056969 Efficacy, tolerability and safety of Sodium picosulphate/magnesium citrate versus 3-L polyethylene glycol for bowel preparation for patients with Inflammatory Bowel Disease Not Available Recruiting Shenzhen Hospital of Southern Medical University Bowel preparation Experimental group:intake sodium picosulfate/magn… Details
NCT05485103 A Prospective Study of the Effect of Modified Colonoscopy Bowel Preparation Program on Intestinal Cleaning, Examination and Disease in Patients With Inflammatory Bowel Disease None RECRUITING Peking Union Medical College Hospital Inflammatory Bowel Diseases DRUG: Polyethylene Glycols Details
NCT01533090 Evaluation of Reduced-volume PEG Bowel Preparation Administered the Same Day of Colonoscopy Not Available Not recruiting Catholic University of the Sacred Heart Colonic Polyps;Cancer Colon;Inflammatory Bowel Di… Drug: polyethylene glycol (PEG);Drug: PEG low vol… Details
NCT04624230 Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis PHASE3 RECRUITING Pfizer Ulcerative Colitis DRUG: tofacitinib Details
NCT06651281 Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011) PHASE3 RECRUITING Merck Sharp & Dohme LLC Crohn Disease|Colitis, Ulcerative DRUG: Tulisokibart|DRUG: Placebo to tulisokibart Details
NCT04857112 Study Evaluating Efficacy and Safety of Amiselimod (MT-1303) in Mild to Moderate Ulcerative Colitis PHASE2 ACTIVE_NOT_RECRUITING Bausch Health Americas, Inc. Ulcerative Colitis DRUG: Low Dose MT-1303|DRUG: High Dose MT-1303|DR… Details
NCT05986136 Activation of Autophagy and Suppression of Apoptosis by Dapagliflozin Attenuates Inflammatory Bowel Disease PHASE2|PHASE3 RECRUITING Mostafa Bahaa Inflammatory Bowel Diseases DRUG: Mesalamine|DRUG: Dapagliflozin 10mg Tab Details

Disease IDDisease NameDefinitionCategoryRelated DrugsMechanism
No data available

Strategy IDTherapeutic StrategySynonymsRelated DrugsMechanism
S04 T-cell homing and retention T-cell trafficking vedolizumab; anti-MAdCAM1 antibodies ; etrolizumab Inhibition of the interaction between α4β7 integrins on T c… Details
S06 Anti-fibrosis fibrosis; tissue remodelling GS-5745; STNM01 Tissue remodelling and destruction in patients with IBD is … Details
S07 Blockade of cytokine Cytokine signalling apremilast; roflumilast; filgotinib; tofacitinib; ABT494; ABT-874; ustekinumab; isankizumab; LY-2525623; AMG139; MEDI2079; guselkumab Various T-cell subsets, their differentiation pathways and … Details

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