| Drug ID: | Drug28 |
|---|---|
| Drug Name: | Metronidazole |
| CID: | 4173 |
| DrugBank ID: | DB00916 |
| Modality: | Small Molecule |
| Groups: | approved |
| US Approved: | YES |
| Other Approved: | YES |
| Identifier: | NCT03794765, , NCT04968951, , NCT02606032, , NCT04186247, , NCT00257699, , NCT00355602, , NCT04979832 |
| Molecular Formula: | C6H9N3O3 |
| Molecular Weight: | 171.15 g/mol |
| Isomeric SMILES: | CC1=NC=C(N1CCO)[N+](=O)[O-] |
| Synonyms: | metronidazole; 443-48-1; Metronidazol; 2-Methyl-5-nitroimidazole-1-ethanol; Anagiardil; Deflamon; Orvagil; Novonidazol; Meronidal; Metronidaz |
| Phase 0: | 15 |
| Phase 1: | 40 |
| Phase 2: | 103 |
| Phase 3: | 107 |
| Phase 4: | 206 |
| Description: | A nitroimidazole used to treat amebiasis; vaginitis; trichomonas infections; giardiasis; anaerobic bacteria; and treponemal infections. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed). |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt258 | 4173 | Metronidazole | 706 | TSPO | Homo sapiens (human) | None | |
| dt259 | 4173 | Metronidazole | 3569 | IL6 | Homo sapiens (human) | None | |
| dt260 | 4173 | Metronidazole | 10864 | SLC22A7 | Mus musculus (house mouse) | 36464106 | [vancomycin co-treated with neomycin co-treated with ampicillin co-treated with metronidazole co-treated with amphotericin B] results in increased expression of SLC22A7 mRNA |
| dt261 | 4173 | Metronidazole | 6519 | SLC3A1 | Rattus norvegicus (Norway rat) | 30545405 | [ampicillin co-treated with neomycin co-treated with gentamicins co-treated with metronidazole co-treated with vancomycin] results in increased expression of SLC3A1 protein |
| dt262 | 4173 | Metronidazole | 123264 | SLC51B | Mus musculus (house mouse) | 24657338 | Metronidazole results in decreased expression of SLC51B mRNA |
| dt263 | 4173 | Metronidazole | 11309 | SLCO2B1 | Mus musculus (house mouse) | 24657338 | Metronidazole results in increased expression of SLCO2B1 mRNA |
| dt264 | 4173 | Metronidazole | 6610 | SMPD2 | Rattus norvegicus (Norway rat) | 30545405 | [ampicillin co-treated with neomycin co-treated with gentamicins co-treated with metronidazole co-treated with vancomycin] results in increased expression of SMPD2 protein |
| dt265 | 4173 | Metronidazole | 6713 | SQLE | Mus musculus (house mouse) | 36464106 | [vancomycin co-treated with neomycin co-treated with ampicillin co-treated with metronidazole co-treated with amphotericin B] results in increased expression of SQLE mRNA |
| dt266 | 4173 | Metronidazole | 8878 | SQSTM1 | Mus musculus (house mouse) | 36535435 | [vancomycin co-treated with neomycin co-treated with metronidazole] promotes the reaction [zinc oxide analog results in increased expression of SQSTM1 protein] |
| dt267 | 4173 | Metronidazole | 6720 | SREBF1 | Mus musculus (house mouse) | 36464106 | [sodium selenite results in increased abundance of selenium] inhibits the reaction [[vancomycin co-treated with neomycin co-treated with ampicillin co-treated with metronidazole co-treated with amphotericin B] results in increased expression of SREBF1 mrn |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT04968951 | Refined Fecal Microbiota Transplantation (FMT) for Ulcerative Colitis (UC) | EARLY_PHASE1 | TERMINATED | Ari M Grinspan | Ulcerative Colitis|FMT|Fecal Microbiota Transplant | DRUG: Metronidazole|DRUG: Placebo|DRUG: Vancomyci… | Details |
| NCT02606032 | Trial of Antimicrobials Versus Placebo in Addition to Fecal Transplant Therapy in Ulcerative Colitis | PHASE2 | COMPLETED | Hamilton Health Sciences Corporation | Ulcerative Colitis | DRUG: Metronidazole|DRUG: Doxycycline|DRUG: Terbi… | Details |
| NCT04979832 | GM-CSF, Fosfomycin and Metronidazole for Pouchitis in Ulcerative Colitis Patients After Restorative IPAA Surgery | PHASE1|PHASE2 | UNKNOWN | Zealand University Hospital | Pouchitis | DRUG: GM-CSF, fosfomycin and metronidazole | Details |
| NCT04186247 | Personalized AZithromycin/metronidAZole Therapy in Pediatric Crohn's Disease (CD) | PHASE2 | COMPLETED | University of North Carolina, Chapel Hill | Crohn Disease|Pediatric Crohns Disease | DRUG: Azithromycin|DRUG: Metronidazole|OTHER: Sta… | Details |
| NCT00257699 | Study of Antibiotics in the Treatment of Colonic Crohn's Disease | PHASE2 | TERMINATED | Mount Sinai Hospital, Canada | Crohn's Disease | DRUG: Metronidazole placebo|DRUG: ciprofloxacin p… | Details |
| NCT03042091 | Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery | EARLY_PHASE1 | UNKNOWN | Thomas Jefferson University | Colorectal Neoplasms; Diverticulitis; Inflammator… | DRUG: Polyethylene Glycol; DRUG: Neomycin; DRUG: … | Details |
| NCT03794765 | Antibiotics as an Adjuvant in Patients With Acute Severe Ulcerative Colitis | PHASE2 | COMPLETED | Post Graduate Institute of Medical Education and Research, Chandigarh | Ulcerative Colitis|Inflammatory Bowel Diseases|Ac… | DRUG: Ceftriaxone|DRUG: Metronidazole|OTHER: Plac… | Details |
| JPRN-jRCTs031180415 | Single center non-randomized study: A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease | Not Available | Not Recruiting | Ishikawa Dai | Inflammatory Bowel Disease (Ulcerative Colitis, C… | AFM therapy arm : three antibiotics, amoxicillin … | Details |
| NCT03593252 | Mechanical Bowel Prep and Prophylactic Oral Antibiotic Use in Children: Implications for Intestinal Surgery Complications | Not Available | Not recruiting | McMaster University | Colostomy Stoma;Ileostomy - Stoma;Jejunostomy Sto… | Drug: Senna;Drug: Sodium Picosulfate, Magnesium O… | Details |
| JPRN-UMIN000025846 | A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease - A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease | Not Available | Recruiting | Juntendo university school of medicine Department of gastroenterology | ulcerative colitis, Crohn's disease | Administration of the fecal material from healthy… | Details |
| NCT03986996 | Antimicrobial Therapy for Ulcerative Colitis (UC) | PHASE2 | TERMINATED | Wolfson Medical Center | Ulcerative Colitis | DRUG: amoxicillin, metronidazole and doxycycline|… | Details |
| NCT06583863 | Parasitic Infections and Ulcerative Colitis: Combining Anti-parasitic and Immunomodulatory Treatments May Achieve Remission | None | COMPLETED | Benha University | Ulcerative Colitis | DRUG: Echinacea Extract|DRUG: MetroNIDAZOLE 500 M… | Details |
| NCT00355602 | Antibiotics for the Treatment of Ulcerative Colitis | None | COMPLETED | University of Dundee | Colitis, Ulcerative | DRUG: Cefuroxime|DRUG: Ciprofloxacin|DRUG: Clarit… | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||
Metronidazole-induced central and peripheral nervous system toxicity
PMID: 25990105
Year: 2015
Relationship Type:
Adverse Effect
Score: 8.3
Comparison of microbiological, histological, and immunomodulatory parameters in…
PMID: 24722235
Year: 2014
Relationship Type:
Treatment
Score: 8.3
Comment in Saudi J Gastroenterol. 2013 Jul-Aug;19(4):139-40. BACKGROUND/AIM: Multidrug resistance 1 (MDR1) gene encodes for P-glycoprotein (P-g…
Metastatic Crohn disease: clearance with metronidazole
PMID: 21238840
Year: 2011
Relationship Type:
Association
Score: 8.1
Metronidazole effects on microbiota and mucus layer thickness in the rat gut
PMID: 20579100
Year: 2010
Relationship Type:
Association
Score: 8.1
Linkage analysis is often followed by association mapping to localize disease variants. In this paper, we evaluate approaches to determine how much …
Comparison of oral prednisone and prednisone combined with metronidazole for in…
PMID: 20051005
Year: 2010
Relationship Type:
Treatment
Score: 8.1
OBJECTIVES: The goal of the studies was the evaluation of platelet-stored (serum) and circulating (plasma) pools of platelet-derived growth factor …
Metronidazole-induced cerebellar toxicity
PMID: 19915830
Year: 2010
Relationship Type:
Adverse Effect
Score: 8.1