| Drug ID: | Drug3 |
|---|---|
| Drug Name: | Ethanol |
| CID: | 702 |
| DrugBank ID: | DB00898 |
| Modality: | Small Molecule |
| Groups: | approved |
| US Approved: | YES |
| Other Approved: | YES |
| Identifier: | NCT03042091 |
| Molecular Formula: | C2H6O |
| Molecular Weight: | 46.07 g/mol |
| Isomeric SMILES: | CCO |
| Synonyms: | ethanol; ethyl alcohol; alcohol; 64-17-5; grain alcohol; Methylcarbinol; Ethyl hydrate; Tecsol; Algrain; Anhydrol |
| Phase 0: | 27 |
| Phase 1: | 72 |
| Phase 2: | 55 |
| Phase 3: | 29 |
| Phase 4: | 49 |
| Description: | A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. [PubChem] |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt12 | 702 | Ethanol | 57498 | KIDINS220 | Mus musculus (house mouse) | 30319688 | Ethanol affects the splicing of KIDINS220 mrna|ethanol results in increased expression of KIDINS220 mRNA |
| dt13 | 702 | Ethanol | 63971 | KIF13A | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF13A mrna|ethanol affects the splicing of KIF13A mRNA |
| dt14 | 702 | Ethanol | 23303 | KIF13B | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF13B mRNA |
| dt15 | 702 | Ethanol | 81930 | KIF18A | Mus musculus (house mouse) | 30517762 | [carbon tetrachloride co-treated with ethanol] results in increased expression of KIF18A mRNA |
| dt16 | 702 | Ethanol | 547 | KIF1A | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF1A mrna|ethanol affects the splicing of KIF1A mRNA |
| dt17 | 702 | Ethanol | 547 | KIF1A | Mus musculus (house mouse) | 29018328 | Ethanol results in decreased expression of KIF1A mRNA |
| dt18 | 702 | Ethanol | 566766 | kif1ab | Danio rerio (zebrafish) | 29361514 | Ethanol results in increased expression of KIF1AB mRNA |
| dt19 | 702 | Ethanol | 23095 | KIF1B | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF1B mrna|ethanol affects the expression of and affects the splicing of KIF1B mRNA |
| dt20 | 702 | Ethanol | 10749 | KIF1C | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF1C mRNA |
| dt21 | 702 | Ethanol | 55605 | KIF21A | Mus musculus (house mouse) | 30319688 | Ethanol affects the splicing of KIF21A mRNA |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT01705522 | Multimodal Approach in IBD Patients | None | UNKNOWN | Clinical Hospital Colentina | Ulcerative Colitis|Crohn's Disease|Nonalcoholic F… | None | Details |
| NCT06814600 | Prevalence of Non-Alcoholic Fatty Liver Disease in Inflammatory Bowel Disease Patients | None | RECRUITING | Centre Hospitalier Universitaire Saint Pierre | NAFLD|Inflammatory Bowel Diseases|Steatosis|Fibro… | DIAGNOSTIC_TEST: Transient elastometry | Details |
| NCT04014413 | Safety and Efficacy of Fecal Microbiota Transplantation | None | RECRUITING | Chinese University of Hong Kong | Crohn Disease|Ulcerative Colitis|Celiac Disease|I… | PROCEDURE: Fecal Microbiota Transplantation | Details |
| NCT01476995 | Prognostic Indicators as Provided by the EPIC ClearView | None | COMPLETED | Epic Research & Diagnostics, Inc. | Coronary Artery Disease|Congestive Heart Failure|… | None | Details |
| ACTRN12622000579796 | A single dose, randomised, 2-period, 2-sequence, crossover, relative bioavailability study comparing 2 x 10 mg R-178 tablets with 2 x 10 mg 2-amino-1,7-dihydro-6H-purine-6-thione tablets administered orally in healthy participants under fasting conditions. | PHASE1 | None | Zenith Technology Corporation Limited | 2-amino-1,7-dihydro-6H-purine-6-thione is indicat… | Single dose, crossover study design whereby each … | Details |
| JPRN-UMIN000045216 | Development of intestinal environment evaluation system by integrated analysis of intestinal microbiota research database - Development of intestinal environment evaluation system by integrated analysis of intestinal microbiota research database | Not Available | Recruiting | Department for Medical Innovation and Translational Medical Science, Kyoto Prefectural University of Medicine | healthy individuals without diseases, inflammator… | None | Details |
| IRCT20150304021342N2 | The effects of dietary modification programme (low-fat, low-carb and high-protein diet) on mood status, fatigue and quality of life in patients with ulcerative colitis | Not Available | Not Recruiting | Esfahan University of Medical Sciences | Ulcerative colitis. Ulcerative colitis | Intervention 1: Intervention group: Patients who … | Details |
| NCT04328259 | Prevalance of non_ Alcoholic Fatty Liver Diseases in Patient With Inflammatory Bowel Diseases Attending Assiut University Hospitals | Not Available | Not recruiting | Assiut University | Inflammatory Bowel Disease Patients | None | Details |
| NCT04306939 | Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study | Not Available | Not recruiting | University of Pittsburgh | Chronic Pancreatitis;Inflammatory Bowel Diseases;… | Other: venipuncture;Behavioral: Questionnaires;Ot… | Details |
| ACTRN12618000122257 | The effects of a multidisciplinary Gastroenterology and Hepatology Integrated Care Clinic approach in patients with chronic gastrointestinal disorders: a randomised controlled trial. | Not Available | Recruiting | Princess Alexandra Hospital | Nonalcoholic Fatty Liver Disease;Nonalcoholic Ste… | The Department of Gastroenterology and Hepatology… | Details |
| JPRN-UMIN000019486 | Enterobacterial analysis for the precise medical care (precision medicine) for diabetes, non-alcoholic lipid liver disease / non-alcoholicity fat hepatitis, inflammatory bowel disease, and irritable bowel syndrome. - Enterobacterial analysis for the precise medical care (precision medicine). | Not Available | Recruiting | Kyoto Prefectural University of Medicine | diabetes, non-alcoholic lipid liver disease / non… | None | Details |
| DRKS00004935 | Attitudes towards eCommunication_in treatment of chronically ill patients _ - EC@T | Not Available | Recruiting | Uniklinikum Freiburg, Institut f Qualitsmanagement und Sozialmedizin | Chronic back pain_Chronic ischemic heart disease_… | Group 1: The EC@T-project consists of three subst… | Details |
| NCT01793168 | Coordination of Rare Diseases at Sanford | Not Available | Recruiting | Sanford Health | Rare Disorders;Undiagnosed Disorders;Disorders of… | None | Details |
| ACTRN12609000913279 | Does cognitive-behavioural therapy (CBT) improve outcomes in inflammatory bowel disease (IBD)? A pilot randomised controlled trial | Not Available | Not Recruiting | Royal Adelaide Hospital | Inflammatory bowel disease (IBD); Inflammatory b… | Preliminary screening of interested subjects will… | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||
[Effects in rats of bee-wax alcohols (D-002) on ulcerative colitis induced by d…
PMID: 29177374
Year: 2017
Relationship Type:
Treatment
Score: 9.3
OBJECTIVES. To investigate the effects of D-002, a mixture of 6 high molecular weight primary aliphatic alcohols, obtained from beeswax (Apis mellife…
Human Defensin-5 Blocks Ethanol and Colitis-Induced Dysbiosis, Tight Junction D…
PMID: 30389960
Year: 2018
Relationship Type:
Treatment
Score: 7.3
Alcohol consumption has been shown to cause dysbiosis, but the mechanism involved in it is unknown. Recurrent colitis is known to induce expression o…
Interactive effects of ethanol on ulcerative colitis and its associated testicu…
PMID: 28965657
Year: 2017
Relationship Type:
Association
Score: 7.3
Available epidemiological reports have indicated an increase in the incidence of ulcerative colitis, as well as alcohol consumption, globally. The pr…
Ethanolic Extract of Atractylodis Rhizoma Ameliorates DSS-Induced Ulcerative Co…
PMID: 40552462
Year: 2025
Relationship Type:
Treatment
Score: 6.5
The utilization of traditional Chinese medicine (TCM) for disease treatment dates back thousands of years. Atractylodis rhizoma (AR) is recognized as…
Phenolic Ethanolic Extracts of Specialty Sorghum Ameliorate Intestinal Colitis …
PMID: 40539417
Year: 2025
Relationship Type:
Mechanism
Score: 6.5
Recently, sorghum [Sorghum bicolor (L.) Moench] has been given great attention as an excellent source of polyphenols that exhibit protective effects …
Ethanolic extract of Momordica charantia L. fruits ameloriates TNBS and AA indu…
PMID: 40260731
Year: 2025
Relationship Type:
Treatment
Score: 6.5
The anti-inflammatory effect of the ethanol extract of Momordica charantia in two different chemically induced inflammatory bowel disease models, whi…
Korean Mistletoe (Viscum album var. coloratum) Ethanol Extracts Enhance Intesti…
PMID: 40227441
Year: 2025
Relationship Type:
Treatment
Score: 6.5
Korean mistletoe (Viscum album var. coloratum, KML) offers remarkable therapeutic potential for a variety of diseases. This study aims to evaluate th…
Anti-inflammatory effects of Rhus javanica ethanol extract for pulmonary and co…
PMID: 39986220
Year: 2025
Relationship Type:
Treatment
Score: 6.5
BACKGROUND: Rhus javanica is a traditional medicinal herb widespread in East Asia, including Korea, China, and Japan. Valued for its antidiarrheal, b…
Pharmacological Inhibition of N-Acylethanolamine Acid Amidase (NAAA) Mitigates …
PMID: 39211986
Year: 2025
Relationship Type:
Treatment
Score: 6.5
BACKGROUND AND AIMS: Intestinal fibrosis, a frequent complication of inflammatory bowel disease, is characterized by stricture formation with no phar…
Hydroethanolic Extract of Lepidium apetalum Willdenow Alleviates Dextran Sulfat…
PMID: 39061864
Year: 2024
Relationship Type:
Treatment
Score: 6.5
The prevalence of ulcerative colitis (UC) has surged in Asian nations recently. The limitations of traditional drug treatments, including biologics, …
Amelioration of Dextran Sodium Sulfate-Induced Colitis in Mice through Oral Adm…
PMID: 38790962
Year: 2024
Relationship Type:
Treatment
Score: 6.5
Inflammatory bowel disease (IBD) is a group of chronic disorders characterized by pain, ulceration, and the inflammation of the gastrointestinal trac…
Therapeutic Potential of Palmitoylethanolamide in Gastrointestinal Disorders
PMID: 38790705
Year: 2024
Relationship Type:
Treatment
Score: 6.5
Palmitoylethanolamide (PEA) is an endocannabinoid-like bioactive lipid mediator belonging to the family of N-acylethanolamines, most abundantly found…
Ziziphus jujuba Miller Ethanol Extract Restores Disrupted Intestinal Barrier Fu…
PMID: 38790680
Year: 2024
Relationship Type:
Treatment
Score: 6.5
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by the disruption of the intestinal barrier. The intestinal barrier is ma…
Morphological, Biochemical and Molecular Docking Evaluation of the Anti-inflamm…
PMID: 38243362
Year: 2023
Relationship Type:
Treatment
Score: 6.5
Ulcerative colitis (UC) is a chronic disorder that involves inflammation. This study was carried out to examine the anti-inflammatory effect of the m…
NF-kB Regulation and the Chaperone System Mediate Restorative Effects of the Pr…
PMID: 37997993
Year: 2023
Relationship Type:
Mechanism
Score: 6.5
Probiotics are live microorganisms that yield health benefits when consumed, generally by improving or restoring the intestinal flora (microbiota) as…
Ethanol-Producing Enterocloster bolteae Is Enriched in Chronic Hepatitis B-Asso…
PMID: 37894093
Year: 2023
Relationship Type:
Association
Score: 6.5
BACKGROUND: Hepatitis B virus (HBV) infection is a global health epidemic that causes fatal complications, leading to liver cirrhosis and hepatocellu…
Hydroethanolic Extract of Fritillariae thunbergii Bulbus Alleviates Dextran Sul…
PMID: 37375714
Year: 2023
Relationship Type:
Treatment
Score: 6.5
The incidence of ulcerative colitis (UC), an inflammatory disorder of the gastrointestinal tract, has rapidly increased in Asian countries over sever…
Ethanol extract of Piper wallichii ameliorates DSS-induced ulcerative colitis i…
PMID: 36806346
Year: 2023
Relationship Type:
Treatment
Score: 6.5
ETHNOPHARMACOLOGICAL RELEVANCE: Piper wallichii (family: Piperaceae), a folk herbal medicine with anti-inflammatory and anti-thrombotic properties, h…
Gas-Mediated Intestinal Microbiome Regulation Prompts the Methanol Extract of S…
PMID: 36771228
Year: 2023
Relationship Type:
Treatment
Score: 6.5
Intestinal dysbiosis plays an important role in the pathogenesis of colitis (UC). Schizonepetae Herba can achieve anti-inflammatory effects as a medi…
Ganoderma lucidum Ethanol Extraction Promotes Dextran Sulphate Sodium Induced C…
PMID: 36553765
Year: 2022
Relationship Type:
Mechanism
Score: 6.5
Popular edible mushrooms Ganoderma lucidum and Gloeostereum incarnatum can improve physical health as a prebiotic and positively alter intestinal mic…