Drug ID:Drug48
Drug Name:Berberine Chloride
CID:12456
DrugBank ID:DB04115
Modality:Small Molecule
Groups:experimental
US Approved:NO
Other Approved:NO
Identifier: NCT02365480
Molecular Formula:C20H18ClNO4
Molecular Weight:371.8 g/mol
Isomeric SMILES:COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
Synonyms:berberine chloride; Berberine hydrochloride; 633-65-8; Berberinium chloride; Benzodioxide; Berberinum; Berberine chloride [JAN]; NSC-163088; UNII-UOT4O1BYV8; UOT4O1BYV8
Phase 0: 2
Phase 1: 4
Phase 2: 15
Phase 3: 15
Phase 4: 21
Description:An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal. [PubChem]

Molecular Structure

2D Molecular Structure

Knowledge Graph

dtIDCIDCompound NameGene IDGene NameSpeciesPubMed IDsAction
dt443 12456 Berberine Chloride 6833 ABCC8 Homo sapiens (human) None
dt444 12456 Berberine Chloride 4780 NFE2L2 Homo sapiens (human) None
dt445 12456 Berberine Chloride 123228 SENP8 Homo sapiens (human) None
dt446 12456 Berberine Chloride 5893 RAD52 Homo sapiens (human) None
dt447 12456 Berberine Chloride 1576 CYP3A4 Homo sapiens (human) None
dt448 12456 Berberine Chloride 43 ACHE Homo sapiens (human) None
dt449 12456 Berberine Chloride 367 AR Homo sapiens (human) None
dt450 12456 Berberine Chloride 3767 KCNJ11 Homo sapiens (human) None
dt451 12456 Berberine Chloride 4137 MAPT Homo sapiens (human) None

  • No data available

Phase Distribution
Phase Description
  • Phase 0: Exploratory trials to assess drug behavior in humans
  • Phase 1: Safety trials to determine safe dosage range
  • Phase 2: Efficacy trials to evaluate therapeutic effects
  • Phase 3: Large-scale trials to confirm efficacy and safety
  • Phase 4: Post-marketing surveillance for long-term safety and efficacy

Trial IDTitlePhaseStatusSponsorIndicationsInterventions
NCT02365480 Berberine Chloride in Preventing Colorectal Cancer in Patients With Ulcerative Colitis in Remission PHASE1 COMPLETED National Cancer Institute (NCI) Ulcerative Colitis DRUG: Berberine Chloride|OTHER: Laboratory Biomar… Details
ChiCTR2400083224 A clinical trial to evaluate the relationship between nitric oxide content in type 3 natural lymphocytes and severity of enteritis and response to drug intervention in patients with inflammatory bowel disease Not Available Not Recruiting Peking University Third Hospital Inflammatory Bowel Disease Trial group:Berberine hydrochloride tablets mesa… Details

Disease IDDisease NameDefinitionCategoryRelated DrugsMechanism
No data available

Strategy IDTherapeutic StrategySynonymsRelated DrugsMechanism
No data available

Comparative Study of Berberis vulgaris Fruit Extract and Berberine Chloride Eff…

PMID: 24363687
Year: 2011
Relationship Type: Treatment Score: 6.1

Antioxidant and immunomodulatory effects of anthocyanins are abundant in berberry fruits suggesting that they may have beneficial effects on inflamma…

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