| Drug ID: | Drug5 |
|---|---|
| Drug Name: | Inositol |
| CID: | 892 |
| DrugBank ID: | DB13178 |
| Modality: | Small Molecule |
| Groups: | NULL |
| US Approved: | NO |
| Other Approved: | YES |
| Identifier: | NCT01111292 |
| Molecular Formula: | C6H12O6 |
| Molecular Weight: | 180.16 g/mol |
| Isomeric SMILES: | C1(C(C(C(C(C1O)O)O)O)O)O |
| Synonyms: | inositol; myo-inositol; 6917-35-7; Myoinositol; mesoinositol; Inosite; Insitolum; Isoinositol; Inositol, i-; Inositol (VAN) |
| Phase 0: | 2 |
| Phase 1: | 3 |
| Phase 2: | 14 |
| Phase 3: | 6 |
| Phase 4: | 8 |
| Description: | NULL |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt32 | 892 | Inositol | 5340 | PLG | Homo sapiens (human) | None | |
| dt33 | 892 | Inositol | 4893 | NRAS | Homo sapiens (human) | None | |
| dt34 | 892 | Inositol | 351 | APP | Homo sapiens (human) | None | |
| dt35 | 892 | Inositol | 7157 | TP53 | Homo sapiens (human) | None | |
| dt36 | 892 | Inositol | 4907 | NT5E | Homo sapiens (human) | None | |
| dt37 | 892 | Inositol | 886385 | pssA | Mycobacterium tuberculosis H37Rv | Inhibitor | |
| dt38 | 892 | Inositol | 351 | APP | Homo sapiens (human) | Inhibitor | |
| dt39 | 892 | Inositol | 887 | CCKBR | Homo sapiens (human) | None | |
| dt40 | 892 | Inositol | 2629 | GBA1 | Homo sapiens (human) | None |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT01111292 | Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia | PHASE1|PHASE2 | TERMINATED | National Cancer Institute (NCI) | Colon Carcinoma|Dysplasia in Crohn Disease|Low Gr… | DRUG: Inositol|OTHER: Placebo | Details |
| ChiCTR-OCC-14004591 | The effect of inositol hexaphosphate and its hydrolysate on the risk of colorectal cancer and the composition of intestinal microbiota | Not Available | Not Recruiting | Medical College of Qingdao University | colorectal cancer | Case (colorectal cancer) group:a newly diagnosed … | Details |
| NCT05539625 | Mini-MARVEL - Mitochondrial Antioxidant Therapy in Ulcerative Colitis | PHASE2 | SUSPENDED | University of Edinburgh | Ulcerative Colitis | DIETARY_SUPPLEMENT: MitoQ|OTHER: Placebo | Details |
| NCT03802214 | Ulcerative Colitis - Vedolizumab- With/Without Prior Exposure to Anti-TNF锛圱umor Necrosis Factor锛塗herapy | None | TERMINATED | Stanford University | Ulcerative Colitis | DRUG: Vedolizumab | Details |
| NCT03907631 | Multi-centre Acute Severe Ulcerative Colitis Prospective Cohort Study (Elevate ASUC) | None | ACTIVE_NOT_RECRUITING | Hull University Teaching Hospitals NHS Trust | Severe Ulcerative Colitis | OTHER: Standard of care | Details |
| NCT01100112 | (CB-01-02/06) Oral Budesonide-Multi-Matrix System (MMX) 9mg Extended Release Tablets | PHASE3 | COMPLETED | Bausch Health Americas, Inc. | Colitis, Ulcerative | DRUG: Budesonide | Details |
| NCT01759056 | Evaluation of an Oral Anti-TNF Antibody in Patients With Active Ulcerative Colitis | PHASE1 | COMPLETED | Avaxia Biologics, Incorporated | Ulcerative Colitis | DRUG: AVX 470|DRUG: Placebo | Details |
| NCT01971970 | Biomarkers of Anti-TNF Treatment in Inflammatory Bowel Disease (IBD) | None | COMPLETED | Erasmus Medical Center | Inflammatory Bowel Diseases | BIOLOGICAL: Infliximab|BIOLOGICAL: Adalimumab | Details |
| NCT00295282 | A Dose-Escalation Study of MDX-1100 in Patients With Active Ulcerative Colitis | PHASE1 | COMPLETED | Bristol-Myers Squibb | Ulcerative Colitis | DRUG: MDX-1100 (anti-CXCL10 human monoclonal anti… | Details |
| NCT03298022 | Efficacy&Safety of ALTB-168 in Patients With Moderate to Severe Active,Anti-TNF Alpha and/or Anti-integrin Refractory UC | PHASE2 | TERMINATED | AltruBio Inc. | Ulcerative Colitis | BIOLOGICAL: ALTB-168 | Details |
| NCT01532648 | Randomized Placebo-Controlled Trial of Budesonide Multi-Matrix System (MMX) 9 Milligrams (mg) in Participants With Ulcerative Colitis Currently on a 5-Aminosalicylic Acid (5-ASA) | PHASE3 | COMPLETED | Bausch Health Americas, Inc. | Ulcerative Colitis | DRUG: Budesonide MMX|DRUG: Placebo|DRUG: 5-ASA | Details |
| NCT01882205 | Comparison Between Chromoendoscopy and Virtual Chromoendoscopy (NBI, I-scan, FICE) for Detection of Neoplasia in Long Standing Ulcerative Colitis | None | RECRUITING | Universitaire Ziekenhuizen KU Leuven | Ulcerative Colitis | DEVICE: Virtual chromoendoscopy|PROCEDURE: Chromo… | Details |
| NCT04743518 | Impact of Anti-TNF, Vedolizumab and Tofacitinib on Aortic Stiffness, Carotid Intima-media Thickness and Cardiovascular Risk of Patients With Ulcerative Colitis | None | UNKNOWN | Centre Hospitalier Universitaire, Amiens | Ulcerative Colitis | OTHER: Aortic pulse wave velocity|OTHER: carotid … | Details |
| NCT01417702 | Endoscopy for Assessment of Mucosal Healing in IBD | None | COMPLETED | University of Erlangen-Nürnberg Medical School | Crohns Disease|Ulcerative Colitis | DEVICE: High-definition white light endoscopy and… | Details |
| NCT06663605 | Phase 1 Study Evaluating PALI-2108 in Healthy Volunteers and Ulcerative Colitis Patients. | PHASE1 | RECRUITING | Palisade Bio | Ulcerative Colitis (UC)|Healthy Volunteer | DRUG: PALI-2108|DRUG: PALI-2108 Placebo | Details |
| NCT04939025 | Multi-interventional Program to Reduce Chronic Ileoanal Pouch Leaks in UC | None | NOT_YET_RECRUITING | London North West Healthcare NHS Trust | Ulcerative Colitis | PROCEDURE: Multi-interventional program | Details |
| NCT03679546 | EFFICACI : EFFicacy of Intravenous Infliximab Versus Vedolizumab After Failure of subCutaneous Anti-TNF in Patients With UlCerative Colitis | PHASE4 | ACTIVE_NOT_RECRUITING | Rennes University Hospital | Ulcerative Colitis | DRUG: Infliximab|DRUG: Vedolizumab Injection | Details |
| NCT02227602 | Anti-Inflammatory Effects of Mango Polyphenolics in Inflammatory Bowel Disease | None | COMPLETED | Texas A&M University | Intestinal Diseases|Ulcerative Colitis|Crohn Dise… | DRUG: Mango polyphenolics | Details |
| NCT03011268 | Anti-tumor Necrosis Factor in Patients With Ulcerative Colitis in Clinical Remission: to Continue or Not? | None | ACTIVE_NOT_RECRUITING | Helse Møre og Romsdal HF | Colitis,Ulcerative | OTHER: Discontinuation of anti-TNF treatment|OTHE… | Details |
| NCT01294410 | Induction and Maintenance Study of BMS-936557 Patients With Moderate to Severe Ulcerative Colitis | PHASE2 | COMPLETED | Bristol-Myers Squibb | Colitis, Ulcerative | DRUG: Placebo|DRUG: Placebo|DRUG: Anti-IP-10 Anti… | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| S04 | T-cell homing and retention | T-cell trafficking | vedolizumab; anti-MAdCAM1 antibodies ; etrolizumab | Inhibition of the interaction between α4β7 integrins on T c… | Details |
Myo-inositol reduces β-catenin activation in colitis
PMID: 28811707
Year: 2017
Relationship Type:
Treatment
Score: 10.0
AIM: To assess dietary myo-inositol in reducing stem cell activation in colitis, and validate pbeta-catenin(S552) as a biomarker of recurrent dysplas…
Mediating role of chiro-inositol metabolites on the effects of HLA-DR-expressin…
PMID: 38886630
Year: 2024
Relationship Type:
Treatment
Score: 9.5
BACKGROUND: Inflammatory bowel disease (IBD), a chronic inflammatory condition, is caused by several factors involving aberrant immune responses. Gen…
Roles of phosphatidylinositol-3-kinases signaling pathway in inflammation-relat…
PMID: 37970476
Year: 2023
Relationship Type:
Treatment
Score: 9.5
BACKGROUND: Phosphatidylinositol-3-kinases (PI3K) is a well-known route in inflammation-related cancer. Recent discovery on PI3K-related genes reveal…
Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colit…
PMID: 35988719
Year: 2022
Relationship Type:
Association
Score: 9.5
BACKGROUND & AIMS: Inositol polyphosphate multikinase (IPMK), an essential enzyme for inositol phosphate metabolism, has been known to mediate major …
SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-di…
PMID: 34320354
Year: 2021
Relationship Type:
Association
Score: 9.5
Phosphoinositides are important molecules in lipid signaling, membrane identity, and trafficking that are spatiotemporally controlled by factors from…
Herbal cake-partitioned moxibustion inhibits colonic autophagy in Crohn's disea…
PMID: 33132650
Year: 2020
Relationship Type:
Treatment
Score: 9.5
BACKGROUND: Autophagy is an evolutionarily conserved biological process in eukaryotic cells that involves lysosomal-mediated degradation and recyclin…
Inositol-Requiring Kinase 1 Regulates Apoptosis via Inducing Endoplasmic Reticu…
PMID: 33043405
Year: 2021
Relationship Type:
Association
Score: 9.5
BACKGROUND: Endoplasmic reticulum stress (ERS) has been studied as critical factor during occurrence and development of ulcerative colitis (UC). Howe…
Modulating effect of inositol hexaphosphate on arachidonic acid-dependent pathw…
PMID: 28797636
Year: 2017
Relationship Type:
Mechanism
Score: 9.3
Cyclooxygenase (COX) and lipoxygenase (LOX) are key enzymes of arachidonic acid metabolism. Their products, prostaglandins and leukotrienes, are invo…
Beta-glucan, inositol and digestive enzymes improve quality of life of patients…
PMID: 28724171
Year: 2017
Relationship Type:
Treatment
Score: 9.3
OBJECTIVE: To evaluate the efficacy of a mixture of beta-glucan, inositol and digestive enzymes in improving gastrointestinal symptoms in patients af…
Critical roles of type III phosphatidylinositol phosphate kinase in murine embr…
PMID: 23322734
Year: 2013
Relationship Type:
Association
Score: 9.1
The metabolism of membrane phosphoinositides is critical for a variety of cellular processes. Phosphatidylinositol-3,5-bisphosphate [PtdIns(3,5)P(2)]…
Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols,…
PMID: 22728312
Year: 2012
Relationship Type:
Association
Score: 9.1
Crohn's disease is a chronic inflammatory condition largely affecting the terminal ileum and large bowel. A contributing cause is the failure of an a…
Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tum…
PMID: 20004201
Year: 2010
Relationship Type:
Mechanism
Score: 9.1
BACKGROUND & AIMS: A large body of evidence supports a correlation between inflammation and cancer, although the molecular mechanisms that govern thi…
LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phospha…
PMID: 32253259
Year: Unknown
Relationship Type:
Treatment
Score: 9.0
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a common prelude to cirrhosis and hepatocellular carcinoma. The genetic rs641738 C>T variant …
Phosphatidylinositol 3-kinase signaling pathway and inflammatory bowel disease:…
PMID: 36939850
Year: 2023
Relationship Type:
Treatment
Score: 6.5
Inflammatory bowel disease (IBD) is a chronic life-limiting disease of gastrointestinal tract characterized by widespread enteric inflammation. IBD i…
Rab5 regulates macropinocytosis by recruiting the inositol 5-phosphatases OCRL …
PMID: 33722976
Year: 2021
Relationship Type:
Association
Score: 6.5
Not found
Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Indu…
PMID: 33374769
Year: 2020
Relationship Type:
Association
Score: 6.5
BACKGROUND: Association of psoriasis with other autoimmune diseases remains an ongoing research subject. OBJECTIVES: To investigate the association …
Expression of inositol-requiring enzyme 1β is downregulated in azoxymethane/dex…
PMID: 30936991
Year: 2019
Relationship Type:
Association
Score: 6.5
Infectious bursal disease (IBD) is one of the most important immunosuppressive diseases that seriously threaten poultry farming and food safety worl…
Lysophosphatidylinositols in inflammation and macrophage activation: Altered le…
PMID: 30251703
Year: 2018
Relationship Type:
Association
Score: 6.3
BACKGROUND & AIMS: Individuals with monogenic disorders of phagocyte function develop chronic colitis that resembles Crohn's disease (CD). We tested…
Dysregulated phosphatidylinositol signaling promotes endoplasmic-reticulum-stre…
PMID: 24135483
Year: 2014
Relationship Type:
Association
Score: 6.3
OBJECTIVE: Primary sclerosing cholangitis (PSC) is a chronic cholestatic disorder that involves inflammatory and fibrotic changes in the bile ducts.…
Anti-inflammatory actions of phosphatidylinositol
PMID: 21360703
Year: 2011
Relationship Type:
Treatment
Score: 6.1
BACKGROUND: We performed a worldwide survey to evaluate the extent to which gastroenterologists who are experts in the field of inflammatory bowel d…