Drug ID:Drug5
Drug Name:Inositol
CID:892
DrugBank ID:DB13178
Modality:Small Molecule
Groups:NULL
US Approved:NO
Other Approved:YES
Identifier: NCT01111292
Molecular Formula:C6H12O6
Molecular Weight:180.16 g/mol
Isomeric SMILES:C1(C(C(C(C(C1O)O)O)O)O)O
Synonyms:inositol; myo-inositol; 6917-35-7; Myoinositol; mesoinositol; Inosite; Insitolum; Isoinositol; Inositol, i-; Inositol (VAN)
Phase 0: 2
Phase 1: 3
Phase 2: 14
Phase 3: 6
Phase 4: 8
Description:NULL

Molecular Structure

2D Molecular Structure

Knowledge Graph

dtIDCIDCompound NameGene IDGene NameSpeciesPubMed IDsAction
dt32 892 Inositol 5340 PLG Homo sapiens (human) None
dt33 892 Inositol 4893 NRAS Homo sapiens (human) None
dt34 892 Inositol 351 APP Homo sapiens (human) None
dt35 892 Inositol 7157 TP53 Homo sapiens (human) None
dt36 892 Inositol 4907 NT5E Homo sapiens (human) None
dt37 892 Inositol 886385 pssA Mycobacterium tuberculosis H37Rv Inhibitor
dt38 892 Inositol 351 APP Homo sapiens (human) Inhibitor
dt39 892 Inositol 887 CCKBR Homo sapiens (human) None
dt40 892 Inositol 2629 GBA1 Homo sapiens (human) None

  • No data available

Phase Distribution
Phase Description
  • Phase 0: Exploratory trials to assess drug behavior in humans
  • Phase 1: Safety trials to determine safe dosage range
  • Phase 2: Efficacy trials to evaluate therapeutic effects
  • Phase 3: Large-scale trials to confirm efficacy and safety
  • Phase 4: Post-marketing surveillance for long-term safety and efficacy

Trial IDTitlePhaseStatusSponsorIndicationsInterventions
NCT01111292 Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia PHASE1|PHASE2 TERMINATED National Cancer Institute (NCI) Colon Carcinoma|Dysplasia in Crohn Disease|Low Gr… DRUG: Inositol|OTHER: Placebo Details
ChiCTR-OCC-14004591 The effect of inositol hexaphosphate and its hydrolysate on the risk of colorectal cancer and the composition of intestinal microbiota NULL Not Recruiting Medical College of Qingdao University colorectal cancer Case (colorectal cancer) group:a newly diagnosed … Details
NCT07176078 Evaluating the Added Benefit of Osteopathic Care to a Flexi-FODMAP Diet in Fibromyalgia Patients With Irritable Bowel Syndrome: a Randomized Sham-controlled Trial NA NOT_YET_RECRUITING Universitair Ziekenhuis Brussel Irritable Bowel Syndrome (IBS)|Fibromyalgia (FM) OTHER: Osteopathic care|OTHER: Sham Osteopathic c… Details
NCT05702879 Combined Microbiota and Metabolic Signature in Ulcerative Colitis Predicts Anti-Inflammatory Therapy Success NULL UNKNOWN Insel Gruppe AG, University Hospital Bern Ulcerative Colitis DRUG: Ozanimod|DRUG: TNF Inhibitor|DRUG: Steroids… Details
NCT05687474 Baby Detect : Genomic Newborn Screening NULL COMPLETED Centre Hospitalier Universitaire de Liege Congenital Adrenal Hyperplasia|Familial Hyperinsu… None Details
NCT05663671 Evaluate Established Anti-DEFA5 mAbs Diagnostic Efficacy and Safety in IBD NULL UNKNOWN Meharry Medical College Inflammatory Bowel Diseases|Ulcerative Colitis|Cr… DIAGNOSTIC_TEST: Diagnostic Test Details
NCT07168434 Saccharomyces Boulardii CNCM I-745 in Irritable Bowel Syndrome PHASE3 RECRUITING Biocodex IBS (Irritable Bowel Syndrome)|IBS-D (Diarrhea-pr… DRUG: Saccharomyces Boulardii 250 MG|DRUG: Placeb… Details
NCT05599347 Pre-treatment With Azithromycin to Reduce Immunogenicity to to Anti-TNF Agents in Patients With Crohn's Disease PHASE2 RECRUITING Rambam Health Care Campus Crohn's Disease Relapse|Biological Substance; Adv… DRUG: Azithromycin Pill|OTHER: Placebo Details
NCT05581420 Oral Versus Intravenous Iron in IBD Patients With Anti-inflammatory Therapy. NA UNKNOWN Leiden University Medical Center Inflammatory Bowel Diseases DRUG: Ferrous fumarate|DRUG: MonoFer Details
NCT05542459 Multi-omics to Predict Responses to Biologics in IBD NULL UNKNOWN Sixth Affiliated Hospital, Sun Yat-sen University Crohn Disease|Ulcerative Colitis DRUG: Biologics Details
NCT05539625 Mini-MARVEL - Mitochondrial Antioxidant Therapy in Ulcerative Colitis PHASE2 WITHDRAWN University of Edinburgh Ulcerative Colitis DIETARY_SUPPLEMENT: MitoQ|OTHER: Placebo Details
NCT05530746 Study on the Diagnostic Value of Multi-omics Combined Detection for Precancerous Lesions of CRC NULL UNKNOWN Changhai Hospital Colorectal Cancer|Precancerous Lesion|Inflammator… None Details
NCT05486585 i-CBT Functional Gastrointestinal Disorders in Youth: the Impact of Negative Illness Understanding and Parental Illness Worries NA ACTIVE_NOT_RECRUITING Aarhus University Hospital Functional Abdominal Pain Syndrome|Functional Gas… OTHER: Internet delivered cognitive behavioural t… Details
NCT05461833 FMT for Post-infectious IBS NA COMPLETED Bogomolets National Medical University Irritable Bowel Syndrome BIOLOGICAL: Fecal transplantation|DRUG: OTILONII … Details
NCT05458531 Monitoring of Inflammatory Conditions NULL COMPLETED University of Nottingham Inflammatory Disease|Crohn Disease|Ulcerative Col… OTHER: Questionnaire|OTHER: Semi-structured inter… Details
NCT05311293 Study on the Molecular Mechanism of Diarrhea-predominant Irritable Bowel Syndrome With Anxiety and Depression Based on Multi-omics Correlation Analysis NULL UNKNOWN Tang-Du Hospital Irritable Bowel Syndrome With Diarrhea DIAGNOSTIC_TEST: Endoscopy Details
NCT07428096 A Study of PALI-2108 in Healthy Volunteers, Patients With Ulcerative Colitis, and Patients With Fibrostenosing Crohn's Disease PHASE1 ACTIVE_NOT_RECRUITING Palisade Bio Fibrostenotic Crohn's Disease DRUG: PALI-2108 Details
NCT05194007 Investigating the Anti-inflammatory Effects of Frondanol in Adults With Inflammatory Bowel Disease PHASE2|PHASE3 COMPLETED Mohammed Bin Rashid University of Medicine and Health Sciences Ulcerative Colitis Chronic Mild|Ulcerative Coliti… DRUG: Frondanol|DRUG: Placebo Details
NCT05124262 Effect of a Low- Fermentable-Oligo-Di- Monosaccharides and Polyols Diet Group Intervention on IBS Symptoms and Fatigue NA UNKNOWN Karolinska Institutet Irritable Bowel Syndrome OTHER: Low- FODMAPdiet group intervention Details
NCT05115370 Vaccination Perception in Inflammatory Conditions - Flu, Pneumonia and COVID-19 NULL COMPLETED University of Nottingham Inflammatory Disease|Rheumatoid Arthritis|Psoriat… OTHER: Semi-structured qualitative interview Details

Disease IDDisease NameDefinitionCategoryRelated DrugsMechanism
No data available

Strategy IDTherapeutic StrategySynonymsRelated DrugsMechanism
S04 T-cell homing and retention T-cell trafficking vedolizumab; anti-MAdCAM1 antibodies ; etrolizumab Inhibition of the interaction between α4β7 integrins on T c… Details

Inhibition of the phosphatidylinositol-3-kinase pathway abrogates polyinosinic:…

PMID: 20836715
Year: 2010
Relationship Type: Mechanism Score: 6.1

BACKGROUND: Inappropriate responses to normal intestinal bacteria may be involved in the development of Inflammatory Bowel Diseases (IBD, e.g. Crohn…

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