Drug ID:Drug55
Drug Name:Amoxicillin
CID:33613
DrugBank ID:DB01060
Modality:Small Molecule
Groups:approved
US Approved:YES
Other Approved:YES
Identifier: NCT05104723
Molecular Formula:C16H19N3O5S
Molecular Weight:365.4 g/mol
Isomeric SMILES:CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)C(=O)O)C
Synonyms:amoxicillin; Amoxycillin; 26787-78-0; Amoxicillin anhydrous; Amoxicilline; p-Hydroxyampicillin; Amopenixin; Amoxicilina; Amolin; Moxal
Phase 0: 16
Phase 1: 59
Phase 2: 74
Phase 3: 140
Phase 4: 356
Description:A broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Amoxicillin is commonly prescribed with clauvanic acid (a beta lactamase inhibitor) as it is susceptible to beta-lacatamase degradation. [PubChem]

Molecular Structure

2D Molecular Structure

Knowledge Graph

dtIDCIDCompound NameGene IDGene NameSpeciesPubMed IDsAction
dt502 33613 Amoxicillin 3123 HLA-DRB1 Homo sapiens (human) None
dt503 33613 Amoxicillin 3122 HLA-DRA Homo sapiens (human) None
dt504 33613 Amoxicillin 5429 POLH Homo sapiens (human) None
dt505 33613 Amoxicillin 2952 GSTT1 Homo sapiens (human) None
dt506 33613 Amoxicillin 3127 HLA-DRB5 Homo sapiens (human) None
dt507 33613 Amoxicillin 1557 CYP2C19 Homo sapiens (human) None
dt508 33613 Amoxicillin 1544 CYP1A2 Homo sapiens (human) None
dt509 33613 Amoxicillin 1576 CYP3A4 Homo sapiens (human) None
dt510 33613 Amoxicillin 3115 HLA-DPB1 Homo sapiens (human) None

  • No data available

Phase Distribution
Phase Description
  • Phase 0: Exploratory trials to assess drug behavior in humans
  • Phase 1: Safety trials to determine safe dosage range
  • Phase 2: Efficacy trials to evaluate therapeutic effects
  • Phase 3: Large-scale trials to confirm efficacy and safety
  • Phase 4: Post-marketing surveillance for long-term safety and efficacy

Trial IDTitlePhaseStatusSponsorIndicationsInterventions
JPRN-jRCTs031180415 Single center non-randomized study: A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease Not Available Not Recruiting Ishikawa Dai Inflammatory Bowel Disease (Ulcerative Colitis, C… AFM therapy arm : three antibiotics, amoxicillin … Details
JPRN-UMIN000025846 A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease - A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease Not Available Recruiting Juntendo university school of medicine Department of gastroenterology ulcerative colitis, Crohn's disease Administration of the fecal material from healthy… Details
NCT03986996 Antimicrobial Therapy for Ulcerative Colitis (UC) PHASE2 TERMINATED Wolfson Medical Center Ulcerative Colitis DRUG: amoxicillin, metronidazole and doxycycline|… Details

Disease IDDisease NameDefinitionCategoryRelated DrugsMechanism
No data available

Strategy IDTherapeutic StrategySynonymsRelated DrugsMechanism
No data available

Amoxicillin modulates gut microbiota to improve short-term high-fat diet induce…

PMID: 36229889
Year: 2022
Relationship Type: Treatment Score: 6.5

BACKGROUND: A high-fat diet (HFD) induced perturbation of gut microbiota is a major contributory factor to promote the pathophysiology of HFD-associa…

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Short-Term Amoxicillin-Induced Perturbation of the Gut Microbiota Promotes Acut…

PMID: 32292395
Year: 2020
Relationship Type: Association Score: 6.5

The intestinal gut microbiota is essential for maintaining host health. Concerns have been raised about the possible connection between antibiotic us…

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