| Drug ID: | Drug71 |
|---|---|
| Drug Name: | Rosuvastatin |
| CID: | 446157 |
| DrugBank ID: | DB01098 |
| Modality: | Small Molecule |
| Groups: | approved |
| US Approved: | YES |
| Other Approved: | YES |
| Identifier: | NCT05912387, , NCT04883840 |
| Molecular Formula: | C22H28FN3O6S |
| Molecular Weight: | 481.5 g/mol |
| Isomeric SMILES: | CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C |
| Synonyms: | Rosuvastatin; 287714-41-4; Creston; X-Plended; Rosuvastatina; ZD-4522; UNII-413KH5ZJ73; 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-; CHEBI:38545; HSDB 7317 |
| Phase 0: | 9 |
| Phase 1: | 307 |
| Phase 2: | 80 |
| Phase 3: | 196 |
| Phase 4: | 197 |
| Description: | Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reducuase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt602 | 446157 | Rosuvastatin | 3156 | HMGCR | Homo sapiens (human) | None | |
| dt603 | 446157 | Rosuvastatin | 3156 | HMGCR | Homo sapiens (human) | 11256847 | Competitive |
| dt604 | 446157 | Rosuvastatin | 3156 | HMGCR | Homo sapiens (human) | 11349148 | Competitive |
| dt605 | 446157 | Rosuvastatin | 3156 | HMGCR | Homo sapiens (human) | 17574412 | Competitive |
| dt606 | 446157 | Rosuvastatin | 3156 | HMGCR | Homo sapiens (human) | 16128575 | Competitive |
| dt607 | 446157 | Rosuvastatin | 25675 | Hmgcr | Rattus norvegicus (Norway rat) | 11256847 | Competitive |
| dt608 | 446157 | Rosuvastatin | 3949 | LDLR | Homo sapiens (human) | None | |
| dt609 | 446157 | Rosuvastatin | 6927 | HNF1A | Homo sapiens (human) | None | |
| dt610 | 446157 | Rosuvastatin | 221458 | KIF6 | Homo sapiens (human) | None | |
| dt611 | 446157 | Rosuvastatin | 8647 | ABCB11 | Homo sapiens (human) | None |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT05912387 | Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study | EARLY_PHASE1 | RECRUITING | Stanford University | Primary Sclerosing Cholangitis; Inflammatory Bowe… | DRUG: Rosuvastatin | Details |
| NCT04883840 | Drug Repurposing - Statins as Microbiota Modulating Agents in Ulcerative Colitis | PHASE2|PHASE3 | RECRUITING | Universitaire Ziekenhuizen KU Leuven | Ulcerative Colitis | DRUG: Rosuvastatin 10mg | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||
Innovative pH-responsive alginate-coated rosuvastatin-loaded chitosan nanoparti…
PMID: 40606616
Year: 2025
Relationship Type:
Treatment
Score: 6.5
This study developed and optimized an innovative oral pH-dependent drug delivery system utilizing rosuvastatin-loaded chitosan nanoparticles (RSV-CSN…
Sub-gingival delivery of simvastatin and rosuvastatin for treatment of chronic …
PMID: 36891284
Year: 2023
Relationship Type:
Treatment
Score: 6.5
BACKGROUND: Statins are lipid-lowering medications that work by blocking rate-limiting enzyme in cholesterol formation. In patients with Chronic peri…
Anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of o…
PMID: 28740344
Year: 2017
Relationship Type:
Treatment
Score: 6.3
AIM: To evaluate the anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium (DSS)…
Protective effect of simvastatin and rosuvastatin on trinitrobenzene sulfonic a…
PMID: 25821305
Year: 2015
Relationship Type:
Association
Score: 6.3
OBJECTIVE: Statins have anti-inflammatory effects that are not directly related to their cholesterol lowering activity. This study was carried out to…