| Drug ID: | Drug72 |
|---|---|
| Drug Name: | Fosfomycin |
| CID: | 446987 |
| DrugBank ID: | DB00828 |
| Modality: | Small Molecule |
| Groups: | approved |
| US Approved: | YES |
| Other Approved: | YES |
| Identifier: | NCT04979832 |
| Molecular Formula: | C3H7O4P |
| Molecular Weight: | 138.06 g/mol |
| Isomeric SMILES: | C[C@H]1[C@H](O1)P(=O)(O)O |
| Synonyms: | FOSFOMYCIN; phosphomycin; 23155-02-4; Fosfocina; Fosfonomycin; Fosfomicina; Fosfomycine; Fosfomycinum; [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid; Antibiotic 833A |
| Phase 0: | 2 |
| Phase 1: | 10 |
| Phase 2: | 14 |
| Phase 3: | 10 |
| Phase 4: | 22 |
| Description: | An antibiotic produced by Streptomyces fradiae. [PubChem] |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt612 | 446987 | Fosfomycin | 93778792 | murA | Escherichia coli K-12 | Inhibitor | |
| dt613 | 446987 | Fosfomycin | 362 | AQP5 | Rattus norvegicus (Norway rat) | 30031112 | Fosfomycin results in decreased expression of AQP5 protein |
| dt614 | 446987 | Fosfomycin | 1401 | CRP | Homo sapiens (human) | 12680319 | Fosfomycin results in decreased expression of CRP protein |
| dt615 | 446987 | Fosfomycin | 93778792 | murA | Escherichia coli K-12 | 24755374 | None |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT04979832 | GM-CSF, Fosfomycin and Metronidazole for Pouchitis in Ulcerative Colitis Patients After Restorative IPAA Surgery | PHASE1|PHASE2 | UNKNOWN | Zealand University Hospital | Pouchitis | DRUG: GM-CSF, fosfomycin and metronidazole | Details |
| JPRN-jRCTs031180415 | Single center non-randomized study: A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease | Not Available | Not Recruiting | Ishikawa Dai | Inflammatory Bowel Disease (Ulcerative Colitis, C… | AFM therapy arm : three antibiotics, amoxicillin … | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| S11 | Improveming Intestinal Microecology | the intestinal microbiota | antibiotics; probiotics; prebiotics; postbiotics; synbiotics; fecal microbiota transplantation (FMT) | The imbalance between beneficial bacteria and harmful patho… | Details |
No related literature
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