Drug ID:Drug87
Drug Name:LTB4
CID:5280492
DrugBank ID:DB12961
Modality:Small Molecule
Groups:NULL
US Approved:NULL
Other Approved:NULL
Identifier: NULL
Molecular Formula:C20H32O4
Molecular Weight:336.5 g/mol
Isomeric SMILES:CCCCC/C=C\\C[C@H](/C=C/C=C/C=C\\[C@H](CCCC(=O)O)O)O
Synonyms:LEUKOTRIENE B4; 71160-24-2; 5,12-Hete; (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid; 5S,12R-diHETE; UNII-1HGW4DR56D; 1HGW4DR56D; 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid; CHEBI:15647; LEUKOTRIENE B4 [MI]
Phase 0: 0
Phase 1: 0
Phase 2: 0
Phase 3: 0
Phase 4: 0
Description:NULL

Molecular Structure

2D Molecular Structure

Knowledge Graph

dtIDCIDCompound NameGene IDGene NameSpeciesPubMed IDsAction
dt726 5280492 Leukotriene B4 59 ACTA2 Homo sapiens (human) 27697457 Leukotriene B4 results in increased expression of ACTA2 protein
dt727 5280492 Leukotriene B4 59 ACTA2 Mus musculus (house mouse) 30818366 Leukotriene B4 results in increased expression of ACTA2 mRNA
dt728 5280492 Leukotriene B4 196 AHR Rattus norvegicus (Norway rat) 28487374 AHR mRNA promotes the reaction [tetrachlorodibenzodioxin results in increased chemical synthesis of leukotriene B4]
dt729 5280492 Leukotriene B4 207 AKT1 Homo sapiens (human) 23747687 Leukotriene B4 inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]
dt730 5280492 Leukotriene B4 240 ALOX5 Homo sapiens (human) 15501964 ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of leukotriene b4]|zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundanc
dt731 5280492 Leukotriene B4 240 ALOX5 Homo sapiens (human) 18096136 Quercetin 3-O-glucuronide inhibits the reaction [ALOX5 protein results in increased chemical synthesis of leukotriene b4]|quercetin 3'-sulfate inhibits the reaction [ALOX5 protein results in increased chemical synthesis of leukotriene b4]|luteolin inhibit
dt732 5280492 Leukotriene B4 240 ALOX5 Homo sapiens (human) 11325678 ALOX5 protein results in increased secretion of leukotriene B4
dt733 5280492 Leukotriene B4 240 ALOX5 Homo sapiens (human) 9609743 Zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [histamine results in increased abundance of leukotriene B4]]|ALOX5 protein results in increased susceptibility to [histamine results in increased abundance of leukotrien
dt734 5280492 Leukotriene B4 240 ALOX5 Homo sapiens (human) 2849922 [tenidap results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of leukotriene b4|[masoprocol results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of leukotriene B4|[RS 43179
dt735 5280492 Leukotriene B4 240 ALOX5 Homo sapiens (human) 10491155 Resveratrol inhibits the reaction [[hydrogen peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of leukotriene b4]|[hydrogen peroxide results in increased activity of ALOX5 protein] which results in incr

  • No data available

Phase Distribution
Phase Description
  • Phase 0: Exploratory trials to assess drug behavior in humans
  • Phase 1: Safety trials to determine safe dosage range
  • Phase 2: Efficacy trials to evaluate therapeutic effects
  • Phase 3: Large-scale trials to confirm efficacy and safety
  • Phase 4: Post-marketing surveillance for long-term safety and efficacy

Trial IDTitlePhaseStatusSponsorIndicationsInterventions
NCT05707429 Sexual Function and Quality of Life Among Patients Suffering From Inflammatory Bowel Disease(Inactive Stage) NULL COMPLETED Assiut University Sexual Function Disturbances|Inflammatory Bowel D… OTHER: The Arabic version of The International In… Details
NCT05701501 Clinical Study of Vitamin B5 in Adjuvant Treatment of IBD NA UNKNOWN Changhai Hospital Inflammatory Bowel Diseases DRUG: Vitamin B5 Tablets|DRUG: placebo Details
NCT05688852 VTX958 for the Treatment of Moderately to Severely Active Crohn's Disease PHASE2 TERMINATED Ventyx Biosciences, Inc Crohn Disease DRUG: VTX958|DRUG: VTX958|DRUG: VTX958 Placebo Details
NCT05687474 Baby Detect : Genomic Newborn Screening NULL COMPLETED Centre Hospitalier Universitaire de Liege Congenital Adrenal Hyperplasia|Familial Hyperinsu… None Details
NCT05684484 Role of Roflumilast in Ulcerative Colitis PHASE4 COMPLETED Tanta University Ulcerative Colitis DRUG: Roflumilast 500 MCG Oral Tablet [DALIRESP]|… Details
NCT05668013 A Study to Evaluate the Long-Term Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease PHASE2 ACTIVE_NOT_RECRUITING Teva Branded Pharmaceutical Products R&D LLC Crohn Disease|Colitis, Ulcerative DRUG: TEV-48574 Dose Regimen A|DRUG: TEV-48574 Do… Details
NCT05666960 R-3750 in Patients With Mild to Moderate Ulcerative Colitis PHASE1 RECRUITING Rise Therapeutics LLC Ulcerative Colitis Chronic Mild|Ulcerative Coliti… DRUG: R-3750 Details
NCT05663671 Evaluate Established Anti-DEFA5 mAbs Diagnostic Efficacy and Safety in IBD NULL UNKNOWN Meharry Medical College Inflammatory Bowel Diseases|Ulcerative Colitis|Cr… DIAGNOSTIC_TEST: Diagnostic Test Details
NCT05659953 LMT503 First-in-human SAD, MAD, and FE Study PHASE1 NOT_YET_RECRUITING Lmito Therapeutics Inc. Inflammatory Bowel Disease|Colitis, Ulcerative|Cr… DRUG: LMT503|DRUG: Placebo Details
NCT05643534 Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Years PHASE3 RECRUITING Ardelyx Irritable Bowel Syndrome With Constipation (IBS-C) DRUG: Tenapanor 50 MG|DRUG: Tenapanor 25 mg bid|D… Details
NCT05638347 A Trial of HRS-7085 Tablet in Healthy Participants With and Without Food Effect. PHASE1 COMPLETED Atridia Pty Ltd. Inflammatory Bowel Disease DRUG: HRS-7085 tablets|DRUG: Placebo tablet Details
NCT05624801 Cholecalciferol Comedication in Patients With Chronic Inflammatory Bowel Diseases (Crohn's Disease or Ulcerative Colitis) - the 5C-study PHASE3 Recruiting University Hospital, Basel, Switzerland IBD Drug: D3 VitaCaps Details
NCT07168434 Saccharomyces Boulardii CNCM I-745 in Irritable Bowel Syndrome PHASE3 RECRUITING Biocodex IBS (Irritable Bowel Syndrome)|IBS-D (Diarrhea-pr… DRUG: Saccharomyces Boulardii 250 MG|DRUG: Placeb… Details
NCT05611671 A Study to Evaluate MORF-057 in Adults With Moderately to Severely Active UC PHASE2 ACTIVE_NOT_RECRUITING Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company) Inflammatory Bowel Diseases|Colitis, Ulcerative DRUG: MORF-057|DRUG: Placebo Details
NCT05549323 A Study to Learn About the Safety, Effects and Pharmacokinetics of Study Medication (PF-07054894) for the Treatment of Ulcerative Colitis PHASE1 TERMINATED Pfizer Ulcerative Colitis DRUG: PF-07054894|DRUG: Placebo Details
NCT07161297 Remimazolam for Colonoscopy in IBD Patients PHASE4 NOT_YET_RECRUITING Humanitas Clinical and Research Center IBD (Inflammatory Bowel Disease) DRUG: Intravenous remimazolam (5 mg initially, wi… Details
NCT05499130 A Study to Test the Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease PHASE2 COMPLETED Teva Branded Pharmaceutical Products R&D, Inc. Crohn Disease|Colitis, Ulcerative DRUG: TEV-48574|DRUG: Placebo Details
NCT05486104 Phase II Study of Hemay005 in Patients With Active Ulcerative Colitis PHASE2 ACTIVE_NOT_RECRUITING Ganzhou Hemay Pharmaceutical Co., Ltd Moderate to Severe Ulcerative Colitis DRUG: Hemay005 tablets|DRUG: Hemay005 placebo tab… Details
NCT07156929 Kinetics and Metabolism of Nicotinamide Provided as a Dietary Supplementation NA COMPLETED University Hospital Schleswig-Holstein Respiratory Infection (for Example, Pneumonia, Br… DIETARY_SUPPLEMENT: Controlled-ileocolonic-releas… Details
NCT05471492 Study to Evaluate the Efficacy and Safety of PF-06480605 in Adult Participants With Moderate to Severe Crohn's Disease PHASE2 WITHDRAWN Telavant, Inc. Crohn Disease DRUG: Investigational Product|DRUG: Placebo Details

Disease IDDisease NameDefinitionCategoryRelated DrugsMechanism
No data available

Strategy IDTherapeutic StrategySynonymsRelated DrugsMechanism
S01 Anti-inflammatory inflammatory 5-Aminosalicylates (5-ASAs); corticosteroids Crohn's disease and ulcerative colitis are the two main com… Details
S06 Anti-fibrosis fibrosis; tissue remodelling GS-5745; STNM01 Tissue remodelling and destruction in patients with IBD is … Details
S07 Blockade of cytokine Cytokine signalling apremilast; roflumilast; filgotinib; tofacitinib; ABT494; ABT-874; ustekinumab; isankizumab; LY-2525623; AMG139; MEDI2079; guselkumab Various T-cell subsets, their differentiation pathways and … Details

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