| Drug ID: | Drug88 |
|---|---|
| Drug Name: | Vitamin D3 |
| CID: | 5280795 |
| DrugBank ID: | DB00169 |
| Modality: | Small Molecule |
| Groups: | approved|nutraceutical |
| US Approved: | YES |
| Other Approved: | YES |
| Identifier: | NCT01640496, , NCT04991324, , NCT03162432 |
| Molecular Formula: | C27H44O |
| Molecular Weight: | 384.6 g/mol |
| Isomeric SMILES: | C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](CCC3=C)O)C |
| Synonyms: | Vitamin D3; cholecalciferol; 67-97-0; Colecalciferol; Calciol; Ricketon; Oleovitamin D3; Deparal; Arachitol; Delsterol |
| Phase 0: | 21 |
| Phase 1: | 72 |
| Phase 2: | 170 |
| Phase 3: | 144 |
| Phase 4: | 130 |
| Description: | Derivative of 7-dehydroxycholesterol formed by ultraviolet rays breaking of the C9-C10 bond. It differs from ergocalciferol in having a single bond between C22 and C23 and lacking a methyl group at C24. [PubChem] |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt736 | 5280795 | Cholecalciferol | 367 | AR | Homo sapiens (human) | None | |
| dt737 | 5280795 | Cholecalciferol | 246 | ALOX15 | Homo sapiens (human) | None | |
| dt738 | 5280795 | Cholecalciferol | 4137 | MAPT | Homo sapiens (human) | None | |
| dt739 | 5280795 | Cholecalciferol | 6097 | RORC | Homo sapiens (human) | None | |
| dt740 | 5280795 | Cholecalciferol | 4780 | NFE2L2 | Homo sapiens (human) | None | |
| dt741 | 5280795 | Cholecalciferol | 10919 | EHMT2 | Homo sapiens (human) | None | |
| dt742 | 5280795 | Cholecalciferol | 1593 | CYP27A1 | Homo sapiens (human) | Substrate | |
| dt743 | 5280795 | Cholecalciferol | 1573 | CYP2J2 | Homo sapiens (human) | Substrate | |
| dt744 | 5280795 | Cholecalciferol | 1576 | CYP3A4 | Homo sapiens (human) | Substrate | |
| dt745 | 5280795 | Cholecalciferol | 1583 | CYP11A1 | Homo sapiens (human) | Substrate |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT01877577 | Supplementation of Vitamin D3 in Patients With Inflammatory Bowel Diseases and Hypovitaminosis D | None | COMPLETED | University of California, San Francisco | Crohn's Disease (CD)|Ulcerative Colitis (UC) | DIETARY_SUPPLEMENT: Vitamin D3 | Details |
| NCT04331639 | High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel Disease Receiving Biologic Therapy | None | RECRUITING | Boston Children's Hospital | Inflammatory Bowel Disease|Crohn Disease|Ulcerati… | DIETARY_SUPPLEMENT: vitamin D3 | Details |
| NCT04225819 | Adjunctive Treatment With Vitamin D3 in Patients With Active IBD | None | SUSPENDED | Massachusetts General Hospital | IBD|Inflammatory Bowel Diseases|Crohn Disease|Ulc… | DIETARY_SUPPLEMENT: Vitamin D3|OTHER: Placebo | Details |
| NCT03162432 | High Dose Interval Vitamin D Supplementation in Patients With IBD Receiving Remicade | PHASE3 | ACTIVE_NOT_RECRUITING | Boston Children's Hospital | IBD|Ulcerative Colitis|Crohn Disease | DRUG: Vitamin D3 | Details |
| NCT02076750 | Weekly Vitamin D in Pediatric IBD | PHASE1|PHASE2 | COMPLETED | Emory University | Inflammatory Bowel Diseases|Skin Pigmentation | DIETARY_SUPPLEMENT: Vitamin D3 (cholecalciferol) | Details |
| NCT04991324 | Cholecalciferol Comedication in IBD - the 5C-study | PHASE3 | COMPLETED | University Hospital, Basel, Switzerland | Inflammatory Bowel Diseases | DRUG: Vitamin D3 | Details |
| NCT01640496 | Vitamin D Treatment in Ulcerative Colitis | None | WITHDRAWN | University of Chicago | Ulcerative Colitis|Inflammatory Bowel Disease | DRUG: Vitamin D3|OTHER: Placebo | Details |
| NCT05624801 | Cholecalciferol Comedication in Patients With Chronic Inflammatory Bowel Diseases (Crohn's Disease or Ulcerative Colitis) - the 5C-study | PHASE3 | Recruiting | University Hospital, Basel, Switzerland | IBD | Drug: D3 VitaCaps | Details |
| NCT03496246 | Vitamin D Status in Inflammatory Bowel Disease | None | UNKNOWN | Assiut University | Vitamin D Deficiency|Inflammatory Bowel Diseases | DIAGNOSTIC_TEST: serum total 25 hydroxycholecalci… | Details |
| CTRI/2017/11/010336 | A study to assess the efficacy of vitamin D supplementation in preventing disease relapse in patients with inflammatory bowel disease. | Not Available | Not Recruiting | KMC Hospital | Health Condition 1: null- Inflammatory bowel dise… | Intervention1: Supplementation of Oral Cholecalif… | Details |
| NCT00621257 | Vitamin D Levels in Children With IBD | None | TERMINATED | Boston Children's Hospital | Inflammatory Bowel Disease|Crohn's Disease|Ulcera… | DIETARY_SUPPLEMENT: ergocalciferol|DIETARY_SUPPLE… | Details |
| NCT03053414 | Vitamin D Repletion and Maintenance in IBD: How Much and How Often | None | WITHDRAWN | Cedars-Sinai Medical Center | Inflammatory Bowel Diseases|Vitamin D Deficiency | DIETARY_SUPPLEMENT: Vitamin D (ergocalciferol and… | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||
Cholecalciferol (vitamin D3): efficacy, safety, and implications in public heal…
PMID: 40551736
Year: 2025
Relationship Type:
Treatment
Score: 7.5
Vitamin D(3) (cholecalciferol) is a fat-soluble secosteroid with essential roles in calcium-phosphorus metabolism, bone health, and an expanding rang…
Daily Vitamin D3 Versus Stoss Vitamin D3 for Correction of 25OHD Deficiency in …
PMID: 40021606
Year: 2025
Relationship Type:
Treatment
Score: 6.5
INTRODUCTION: Vitamin D deficiency is common in Paediatric Inflammatory Bowel Disease (PIBD) and has been implicated in disease pathogenesis and dise…
Vitamin D3 induces stem cell activation via Lgr5-Bmi1 expression and improving …
PMID: 38455625
Year: 2023
Relationship Type:
Treatment
Score: 6.5
Conventional therapy for inflammatory bowel disease using long-term anti-inflammatory drugs does not seem to provide optimal results. Adjuvant therap…
An efficient co-delivery system based on multilayer structural nanoparticles fo…
PMID: 37952331
Year: 2024
Relationship Type:
Treatment
Score: 6.5
Multilayer structural nanoparticles (MSNPs) fabricated by layer-by-layer self-assembly were used for the co-encapsulation of resveratrol (Res) and vi…
Immunological Study of IFN-γ, ICAM-4, and Vitamin D3 Markers among Gastrointest…
PMID: 36708580
Year: 2023
Relationship Type:
Association
Score: 6.5
OBJECTIVE: The current study was conducted to investigate the roles of ICAM-4, IFN-gamma, and vitamin D3 markers among benign and malignant gastroint…
Effect of Vitamin D3 in Composition of Original Rectal Suppositories on Paramet…
PMID: 33788108
Year: 2021
Relationship Type:
Association
Score: 6.5
The effect of vitamin D3 in the composition of original rectal suppositories on the content of products of oxidative modification of proteins in muco…
A New Model Based on 25-Hydroxyvitamin D3 for Predicting Active Crohn's Disease…
PMID: 30647532
Year: 2018
Relationship Type:
Association
Score: 6.3
BACKGROUND: The association between vitamin D3 and activity of Crohn's disease (CD) is unclear in Chinese patients. In this study, we aimed to evalua…
Correlations of 25-hydroxyvitamin D3 level in patients with ulcerative colitis …
PMID: 30229839
Year: 2018
Relationship Type:
Treatment
Score: 6.3
OBJECTIVE: To investigate the correlations between 25-hydroxyvitamin D3 (25-OHD3) level in patients with ulcerative colitis (UC) and inflammation lev…
Impact of High-Dose Vitamin D3 Supplementation in Patients with Crohn's Disease…
PMID: 27975236
Year: 2017
Relationship Type:
Treatment
Score: 6.3
AIM: To assess the tolerability and efficacy of high-dose vitamin D3 in patients with Crohn's disease (CD). METHODS: This was a randomized, double-bl…
The role of vitamin D3 in inflammatory bowel diseases
PMID: 25166432
Year: 2014
Relationship Type:
Treatment
Score: 6.3
Vitamin D3, combined with its nuclear receptor, regulates more than 900 genes, which is the reason why its effect is pleiotropic. Among other effects…
Comment On: Clinical Trial: Vitamin D3 Treatment in Crohn's Disease: A Randomiz…
PMID: 28094596
Year: 2011
Relationship Type:
Treatment
Score: 6.1
BACKGROUND: Vitamin D has immune-regulatory functions in experimental colitis, and low vitamin D levels are present in Crohn's disease. METHODS: We p…
Vitamin D3 treatment of Crohn's disease patients increases stimulated T cell IL…
PMID: 21050239
Year: 2010
Relationship Type:
Treatment
Score: 6.1
BACKGROUND: Vitamin D3 has shown immune-modulating effects in CD4+ T cells from Crohn's disease patients in vitro. AIM: To investigate the effects of…
[Pleiotropic action of vitamin D3 with particular stress on its role in gastroi…
PMID: 20608430
Year: 2010
Relationship Type:
Association
Score: 6.1
This review presents aspects of pleiotropic actions of vitamin D3, in particular amongst the development period population. It describes the relation…
Clinical trial: vitamin D3 treatment in Crohn's disease - a randomized double-b…
PMID: 20491740
Year: 2010
Relationship Type:
Treatment
Score: 6.1
BACKGROUND: Vitamin D has immune-regulatory functions in experimental colitis, and low vitamin D levels are present in Crohn's disease. AIM: To asses…
Differences in outcomes between cholecalciferol and ergocalciferol supplementat…
PMID: 22233182
Year: 2012
Relationship Type:
Treatment
Score: 5.1
AIM: Vitamin D deficiency is a global health issue associated with increased health-care costs, and could play a role in the pathogenesis and managem…