| Drug ID: | Drug9 |
|---|---|
| Drug Name: | Aspirin |
| CID: | 2244 |
| DrugBank ID: | DB00945 |
| Modality: | Small Molecule |
| Groups: | approved |
| US Approved: | YES |
| Other Approved: | YES |
| Identifier: | NCT05104229 |
| Molecular Formula: | C9H8O4 |
| Molecular Weight: | 180.16 g/mol |
| Isomeric SMILES: | CC(=O)OC1=CC=CC=C1C(=O)O |
| Synonyms: | aspirin; ACETYLSALICYLIC ACID; 50-78-2; 2-(Acetyloxy)benzoic acid; Acetosal; Acenterine; Acetophen; Acetosalin; Aspirdrops; Salcetogen |
| Phase 0: | 48 |
| Phase 1: | 161 |
| Phase 2: | 256 |
| Phase 3: | 360 |
| Phase 4: | 470 |
| Description: | The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt70 | 2244 | Aspirin | 4056 | LTC4S | Homo sapiens (human) | None | |
| dt71 | 2244 | Aspirin | 10463 | SLC30A9 | Homo sapiens (human) | None | |
| dt72 | 2244 | Aspirin | 1591 | CYP24A1 | Homo sapiens (human) | None | |
| dt73 | 2244 | Aspirin | 3123 | HLA-DRB1 | Homo sapiens (human) | None | |
| dt74 | 2244 | Aspirin | 3565 | IL4 | Homo sapiens (human) | None | |
| dt75 | 2244 | Aspirin | 1117 | CHI3L2 | Homo sapiens (human) | Inhibitor | |
| dt76 | 2244 | Aspirin | 2138 | EYA1 | Homo sapiens (human) | None | |
| dt77 | 2244 | Aspirin | 1307 | COL16A1 | Homo sapiens (human) | Inhibitor | |
| dt78 | 2244 | Aspirin | 10 | NAT2 | Homo sapiens (human) | None | |
| dt79 | 2244 | Aspirin | 136227 | COL26A1 | Homo sapiens (human) | None |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT05104229 | SAVES-IBD: Safety & Efficacy of Aspirin vs. Standard of Care for VTE Prophylaxis After IBD Surgery | PHASE3 | WITHDRAWN | Stefan Holubar MD MS FACS, FASCRS | Crohn Disease|Ulcerative Colitis|Venous Thromboem… | DRUG: Aspirin 81Mg Ec Tab|DRUG: Standard of Care | Details |
| ISRCTN12358813 | Asp-PSC: effect of aspirin on reducing cancer & improving outcomes in primary sclerosing cholangitis | PHASE3 | Recruiting | Imperial College London | Primary sclerosing cholangitis (PSC) and inflamma… | Participants will be randomised using OpenClinica… | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||
Resveratrol and Resveratrol-Aspirin Hybrid Compounds as Potent Intestinal Anti-…
PMID: 32847114
Year: 2020
Relationship Type:
Treatment
Score: 7.5
Resveratrol (3,4,5-Trihydroxy-trans-stilbene) is a naturally occurring polyphenol that exhibits beneficial pleiotropic health effects. It is one of t…
Aspirin after completion of standard adjuvant therapy for colorectal cancer (AS…
PMID: 39824200
Year: 2025
Relationship Type:
Treatment
Score: 6.5
BACKGROUND: Aspirin is a simple, globally available medication that has been shown to reduce the incidence of colorectal cancer. We aimed to evaluate…
The Effect of Low-Dose Aspirin on Disease Activity in Pregnant Individuals With…
PMID: 39773571
Year: 2025
Relationship Type:
Treatment
Score: 6.5
INTRODUCTION: Low-dose aspirin (LDA) is recommended for pregnant individuals at elevated risk for hypertensive disorders of pregnancy (HDP). However,…
Low-Dose Aspirin Use Does Not Increase Disease Activity in Pregnant Patients wi…
PMID: 38493274
Year: 2024
Relationship Type:
Adverse Effect
Score: 6.5
BACKGROUND: The adverse effects of non-steroidal anti-inflammatory (NSAID) drugs on the gastrointestinal system are well recognized, but the effect o…
The impact of aspirin use on outcomes in patients with inflammatory bowel disea…
PMID: 38117356
Year: 2023
Relationship Type:
Association
Score: 6.5
BACKGROUND: Inflammatory bowel disease (IBD) is an inflammatory disorder that can increase the risk of mortality. Aspirin is an anti-inflammatory dru…
Potential beneficial effects of long-term aspirin use on the prevalence of colo…
PMID: 37855925
Year: 2024
Relationship Type:
Association
Score: 6.5
PURPOSE: Whether long-term aspirin usage is associated with colorectal cancer (CRC) risk needs more evidence. The study evaluated the association bet…
Aspirin Inhibits Carcinogenesis of Intestinal Mucosal Cells in UC Mice Through …
PMID: 35946886
Year: 2022
Relationship Type:
Mechanism
Score: 6.5
BACKGROUND: Colorectal cancer is related to ulcerative colitis. This study aimed to investigate the effects of aspirin on non-specific inflammation d…
Risk factors for small-intestinal mucosal breaks beyond aspirin
PMID: 35642270
Year: 2022
Relationship Type:
Association
Score: 6.5
BACKGROUND AND AIM: There remains lots of unknowns for small intestinal mucosal breaks (SIMBs). The application of magnetic controlled capsule endosc…
Cost-Effectiveness of Aspirin for Extended Venous Thromboembolism Prophylaxis A…
PMID: 35277799
Year: 2022
Relationship Type:
Association
Score: 6.5
BACKGROUND AND PURPOSE: Venous thromboembolism extended prophylaxis after inflammatory bowel disease surgery remains controversial. The purpose of th…
Short-term aspirin and statin chemoprophylaxis did not reduce the risk of devel…
PMID: 34657610
Year: 2021
Relationship Type:
Association
Score: 6.5
BACKGROUND: Chemoprevention of colorectal neoplasia with aspirin and statins is under-investigated in Black patients. Since Black patients suffer dis…
A novel gene associated with small bowel bleeding in patients taking low-dose a…
PMID: 34059446
Year: 2021
Relationship Type:
Association
Score: 6.5
OBJECTIVE: We have previously revealed the clinical factors and genetic polymorphisms associated with gastrointestinal mucosal injury and bleeding, i…
ZINC40099027 Promotes Gastric Mucosal Repair in Ongoing Aspirin-Associated Gast…
PMID: 33920786
Year: 2021
Relationship Type:
Mechanism
Score: 6.5
Nonsteroidal anti-inflammatory drugs cause gastric ulcers and gastritis. No drug that treats GI injury directly stimulates mucosal healing. ZINC40099…
Aspirin Use and Risk of Colorectal Cancer Among Older Adults
PMID: 33475710
Year: 2021
Relationship Type:
Clinical Trial
Score: 6.5
IMPORTANCE: Although aspirin is recommended for the prevention of colorectal cancer (CRC) among adults aged 50 to 59 years, recent data from a random…
Nonsteroidal anti-inflammatory drugs but not aspirin are associated with a lowe…
PMID: 32201976
Year: 2020
Relationship Type:
Association
Score: 6.5
BACKGROUND: Although nonsteroidal anti-inflammatory drugs (NSAIDs) reduce colorectal cancer (CRC) risk, their role in preventing post-colonoscopy CRC…
Yogurt Containing Lactobacillus gasseri Mitigates Aspirin-Induced Small Bowel I…
PMID: 28052291
Year: 2017
Relationship Type:
Treatment
Score: 6.3
BACKGROUND: Although there is evidence about the beneficial effects of probiotics, their effects on aspirin-induced small bowel injuries have not bee…
Prevention of damage induced by aspirin in the GI tract
PMID: 22542153
Year: 2012
Relationship Type:
Adverse Effect
Score: 6.1
Low-dose aspirin (325 mg or less) alone and in combination with other antiplatelet agents is widely used for the management of cardiovascular disease…
Aspirin in the aetiology of Crohn's disease and ulcerative colitis: a European …
PMID: 21790683
Year: 2011
Relationship Type:
Association
Score: 6.1
BACKGROUND: Aspirin has detrimental effects on the gastrointestinal tract mucosa and may play a role in the aetiology of inflammatory bowel disease. …
Aspirin-triggered lipoxin enhances macrophage phagocytosis of bacteria while in…
PMID: 21659618
Year: 2011
Relationship Type:
Treatment
Score: 6.1
The macrophage plays a major role in the induction and resolution phases of inflammation; however, how lipid mediator-derived signals may modulate ma…