ID：P1
Pathogenesis：Genetics
Other Terms：Gene variant; Heredity; Genetic factor; Epigenetic modifications; IL23R
Description：Genome wide association studies and computerised (in silico) meta-analyses have identified and confirmed 71 susceptibility loci for Crohn's disease on 17 chromosomes so far.Genome wide association studies also link inflammatory extraintestinal symptoms8 (ie, ankylosing spondylitis, non-drug induced osteoporosis) and associated autoimmune diseases9 (ie, asthma, multiple sclerosis, type 1 diabetes, autoimmune thyroid disease, and coeliac disease) known from epidemiological studies on a molecular level with shared susceptibility loci and can explain ethnic differences10 in the distribution of these associated diseases

Related Literature

Lack of common NOD2 variants in Japanese patients with Crohn's disease.
📅 Publication Date: 2025-07-23
📖 Source: Gastroenterology
# PMID: 12105836
BACKGROUND & AIMS: Previous studies have linked Crohn's disease (CD) to the pericentromeric region of chromosome 16 (IBD1). Three independent studies of Western populations have r…
NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population.
📅 Publication Date: 2025-07-23
📖 Source: Alimentary pharmacology & therapeutics
# PMID: 12823148
BACKGROUND: Crohn's disease affects people world-wide, but the incidence in Asia is lower than in Western countries. This difference may be due to genetic and/or environmental fac…
Genetic origin of IBD
📅 Publication Date: 2004-06-01
📖 Source: Inflamm Bowel Dis
# PMID: 15168824
🔗 DOI: 10.1097/00054725-200402001-00003
Comment on Nat Genet. 2000 Dec;26(4):398-9. Busjahn et al reported finding linkage between PPARG (3p25) and being a dizygotic (DZ) twin. We differentiate, as do the authors,…
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
📅 Publication Date: 2025-07-23
📖 Source: Science (New York, N.Y.)
# PMID: 17068223
The inflammatory bowel diseases Crohn's disease and ulcerative colitis are common, chronic disorders that cause abdominal pain, diarrhea, and gastrointestinal bleeding. To identif…
A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1.
📅 Publication Date: 2025-07-23
📖 Source: Nature immunology
# PMID: 19349988
A common mutation in the gene encoding the cytoplasmic sensor Nod2, involving a frameshift insertion at nucleotide 3020 (3020insC), is strongly associated with Crohn's disease. Ho…
Ulcerative colitis.
📅 Publication Date: 2025-07-23
📖 Source: The New England journal of medicine
# PMID: 22047562
Crohn's disease.
📅 Publication Date: 2025-07-23
📖 Source: Lancet (London, England)
# PMID: 22914295
Crohn's disease is a relapsing systemic inflammatory disease, mainly affecting the gastrointestinal tract with extraintestinal manifestations and associated immune disorders. Geno…