ID：P10
Pathogenesis：Angiogenesis and lymphangiogenesis
Other Terms：Angiogenesis; (VEGF)-A; Lymphangiogenesis;
Description：The growth of new vessels and the expansion of tissue-specific microvascular networks, angiogenesis, is a component of IBD pathogenesis. Mucosal and plasma levels of vascular endothelial growth factor (VEGF)-A are upregulated in patients with IBD, as are levels of the receptor VEGF-R2

Related Literature

Angiogenesis as a novel component of inflammatory bowel disease pathogenesis
📅 Publication Date: 2006-06-10
📖 Source: Gastroenterology
# PMID: 16762629
🔗 DOI: 10.1053/j.gastro.2006.03.054
BACKGROUND: Genetic variants in DLG5, which encodes a scaffolding protein on chromosome 10q23, and tumor necrosis factor (TNF)-alpha, encoding a proinflammatory cytokine on chro…
VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis
📅 Publication Date: 2008-11-18
📖 Source: Gastroenterology
# PMID: 19013462
🔗 DOI: 10.1053/j.gastro.2008.09.064
Comment in Inflamm Bowel Dis. 2008 Apr;14(4):575-6. Crohn's disease (CD) and ulcerative colitis (UC) are idiopathic inflammatory conditions of the gut. Our goal was to inves…
Inflammation-induced lymphangiogenesis and lymphatic dysfunction.
📅 Publication Date: 2025-07-23
📖 Source: Angiogenesis
# PMID: 24449090
The lymphatic system is intimately linked to tissue fluid homeostasis and immune cell trafficking. These functions are paramount in the establishment and development of an inflamm…
VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease
📅 Publication Date: 2014-08-09
📖 Source: J Clin Invest
# PMID: 25105363
🔗 DOI: 10.1172/JCI72189
BACKGROUND AND AIMS: Bone marrow-derived mesenchymal stem cell (MSC) is widely studied in inflammatory bowel disease (IBD) in basic and clinical research. However, patients with…